FlyBase Allele Report: Dmel\hth[C1]

General Information

Symbol

Dmel\hth^C1

Species

D. melanogaster

Name

FlyBase ID

FBal0065835

Feature type

allele

Associated gene

Dmel\hth

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Casares and Mann, 1998)

Mutagen

ethyl methanesulfonate

(Rieckhof et al., 1997)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G1793A. Amino acid replacement: V181I.

(Kurant et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:10,585,928..10,585,928 [-]

Nucleotide change:

G10585928A

Reported nucleotide change:

G1793A

Amino acid change:

V181I

(Kurant et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates central nervous system cancer

modeled by N^UAS.icd

(Zacharioudaki et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable (with hth^CPTI000378)

(Choo et al., 2011)

visible

(Casares and Mann, 1998)

visible | homeotic | male | recessive | somatic clone

(Ryoo et al., 1999)

visible | homeotic | recessive | somatic clone

(Ryoo et al., 1999)

visible | recessive | somatic clone

(Wu and Cohen, 1999)

visible | somatic clone

(Pichaud and Casares, 2000)

Phenotype Manifest In

abdominal tergite 2 | male | somatic clone

(Ryoo et al., 1999)

abdominal tergite 3 | male | somatic clone

(Ryoo et al., 1999)

abdominal tergite & trichome | male | somatic clone

(Ryoo et al., 1999)

antenna

(Casares and Mann, 1998)

antenna | distal | somatic clone

(Ryoo et al., 1999)

coxa | somatic clone

(Wu and Cohen, 1999)

embryonic abdominal segment 1

(Rieckhof et al., 1997)

eye | ectopic | somatic clone

(Pichaud and Casares, 2000)

femur | somatic clone

(Wu and Cohen, 1999)

gena | somatic clone

(Pichaud and Casares, 2000)

larval abdominal lch5 neuron

(Kurant et al., 2001)

mesothoracic dorsal triscolopidial chordotonal organ dch3 & neuron

(Kurant et al., 2001)

mesothoracic ventral denticle belt

(Rieckhof et al., 1997)

metathoracic dorsal triscolopidial chordotonal organ dch3 & neuron

(Kurant et al., 2001)

metathoracic ventral denticle belt

(Rieckhof et al., 1997)

presumptive embryonic/larval peripheral nervous system

(Kurant et al., 2001)

prothoracic dorsal triscolopidial chordotonal organ dch3 & neuron

(Kurant et al., 2001)

prothoracic ventral denticle belt

(Rieckhof et al., 1997)

rostral membrane | somatic clone

(Pichaud and Casares, 2000)

trochanter | somatic clone

(Wu and Cohen, 1999)

Detailed Description

Statement

Reference

Homozygous embryos show a reduction in the number of LCh5 neurons, loss of thoracic DCh3 neurons and an abnormal pattern of the axonal trajectories in the PNS.

(Kurant et al., 2001)

Somatic clones in the head, induced during larval stages, lead to ectopic eye structures in the head. the ventral head region (gena and rostral membrane) is reduced as a consequence of the production of ectopic eyes, and the maxillary palps are frequently absent or abnormal in these clones.

(Pichaud and Casares, 2000)

Homozygous hth^C1 somatic clones are capable of differentiating bristles.

(Wu and Cohen, 2000)

Homozygous clones in the distal antenna show transformation to distal leg. Clones in tergites 2 and 3 in males result in a darkly pigmented cuticle, typical of a posterior tergite identity. Homozygous clones in anterior tergites in males also have a lower density of trichomes than surrounding wild-type cuticle, indicating a transformation to a more posterior identity.

(Ryoo et al., 1999)

Homozygous clones in the leg cause fusion of the coxa, trochanter and femur segments but do not cause defects in distal leg segments.

(Wu and Cohen, 1999)

Clones in the antenna exhibit autonomous transformation to leg.

(Casares and Mann, 1998)

The normal pattern of the cuticle is disrupted in homozygous embryos and hth^C1/Df(3R)hth embryos, with hth^C1/Df(3R)hth embryos having a stronger phenotype than homozygous embryos. The denticle belts of the thoracic segments have an abdominal-like morphology in homozygous embryos, and the first abdominal segment is transformed to an identity resembling the fifth abdominal segment. In addition, segmental fusions are seen in hth^C1/Df(3R)hth embryos.

(Rieckhof et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

hth^C1 has prothoracic ventral denticle belt phenotype, suppressible by Mmus\Meis1^hs.Tag:MYC

(Rieckhof et al., 1997)

hth^C1 has metathoracic ventral denticle belt phenotype, suppressible by Mmus\Meis1^hs.Tag:MYC

(Rieckhof et al., 1997)

hth^C1 has mesothoracic ventral denticle belt phenotype, suppressible by Mmus\Meis1^hs.Tag:MYC

(Rieckhof et al., 1997)

hth^C1 has embryonic abdominal segment 1 phenotype, suppressible by Mmus\Meis1^hs.Tag:MYC

(Rieckhof et al., 1997)

Other

Statement

Reference

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, abd-A^M1, hth^C1 has embryonic abdominal segment phenotype

(Rieckhof et al., 1997)

Ubx^Ia.hs, hth^C1 has embryonic head phenotype

(Rieckhof et al., 1997)

Ubx^Ia.hs, hth^C1 has embryonic mesothoracic segment phenotype

(Rieckhof et al., 1997)

Ubx^Ia.hs, hth^C1 has embryonic metathoracic segment phenotype

(Rieckhof et al., 1997)

Ubx^Ia.hs, hth^C1 has embryonic prothoracic segment phenotype

(Rieckhof et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The abdominal segments of Antp^Ns-rvC3 Scr^C1 abd-A^M1 Abd-B^M8 hth^C1 mutant embryos all resemble the third abdominal segment. Ubiquitous expression of Ubx^Ia.hs in hth^C1/hth^C1 embryos transforms all three thoracic segments and 2-3 head segments into A5-like segments. Cuticles secreted by exd¹ embryos lacking both maternal and zygotic exd function appear indistinguishable from those secreted by exd¹ embryos lacking both maternal and zygotic exd function and also hemizygous for hth^C1. exd¹/exd¹; hth^C1/hth^C1 double mutant embryos have stronger transformations than either exd¹/exd¹ or hth^C1/hth^C1 single mutant embryos. The homozygous embryonic phenotype is partially rescued by Mmus\Meis1^{hs.T:Hsap\MYC}.

(Rieckhof et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

hth^5E04

(Rieckhof et al., 1997)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Germ line clonal analysis indicates that hth function is not required maternally.

(Rieckhof et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

hth^C1

(Zacharioudaki et al., 2016, Ahn et al., 2011, Choo et al., 2011)

hthC1

(Pichaud and Casares, 2000)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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