FlyBase Allele Report: Dmel\N[UAS.icd]

General Information

Symbol

Dmel\N^UAS.icd

Species

D. melanogaster

Name

FlyBase ID

FBal0120742

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

P{UAS-N.icd}

Also Known As

UAS-N^icd, UAS-Nicd

Key Links

Transgenic product class

inframe_deletion

(Cooper, 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Cooper, 2000)

Mutagen

in vitro construct

(Cooper, 2000, Cooper and Bray, 2000)

Progenitor genotype

Carried in construct

P{UAS-N.icd}

Cytology

Description

UAS sequences drive expression of the intracellular domain of N.

(Cooper, 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of central nervous system cancer

CEA

(Zacharioudaki et al., 2016)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of central nervous system cancer

is ameliorated by hth^C1

(Zacharioudaki et al., 2016)

is exacerbated by mira^HMS00347

(Zacharioudaki et al., 2016)

is ameliorated by svp¹

(Zacharioudaki et al., 2016)

is ameliorated by hth^B2

(Zacharioudaki et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

hyperplasia, with Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

hyperplasia | somatic clone, with Scer\GAL4^Act5C.PI

(Djiane et al., 2013)

hyperplasia | somatic clone | third instar larval stage, with Scer\GAL4^FRT.Act5C

(Slaninova et al., 2016)

hyperplasia | third instar larval stage, with Scer\GAL4^ptc.PU

(Slaninova et al., 2016)

Phenotype Manifest In

mesothoracic tergum & macrochaeta, with Scer\GAL4^sca-C253

(Hasson et al., 2005)

sensory mother cell, with Scer\GAL4^sca-C253

(Hasson et al., 2005)

wing disc, with Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

wing disc | somatic clone, with Scer\GAL4^Act5C.PI

(Djiane et al., 2013)

wing disc | somatic clone | third instar larval stage, with Scer\GAL4^FRT.Act5C

(Slaninova et al., 2016)

wing disc | third instar larval stage, with Scer\GAL4^ptc.PU

(Slaninova et al., 2016)

Detailed Description

Statement

Reference

Expression of N^Scer\UAS.icd under the control of Scer\GAL4^{Scer\FRT.Act5C} in third instar wing disc clones leads to wing disc hyperplasia, significantly higher levels of extracellular acidification, a decrease in the glycolytic reserve, lower oxygen consumption rate, and lower production of mitochondrial ATP in the wing disc, as compared to controls.

Expression of N^Scer\UAS.icd under the control of Scer\GAL4^ptc.PU leads to wing disc hyperplasia in third instar larvae.

(Slaninova et al., 2016)

Expression of N^Scer\UAS.icd in randomly generated clones throughout the wing disc causes hyperplasia.

Scer\GAL4^ptc-559.1-mediated expression of N^Scer\UAS.icd causes overgrowth of the wing disc, primarily along one axis.

(Djiane et al., 2013)

Expression of N^Scer\UAS.icd under the control of Scer\GAL4^sca-C253 leads to bristle loss on the notum, following suppression of sensory organ precursor cells.

(Hasson et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

N^UAS.icd, Scer\GAL4^ptc.PU has hyperplasia | third instar larval stage phenotype, suppressible | partially by Ldh^KK102330, Scer\GAL4^ptc.PU

(Slaninova et al., 2016)

N^UAS.icd, Scer\GAL4^ptc.PU has hyperplasia | third instar larval stage phenotype, suppressible | partially by Hex-A^KK100831, Scer\GAL4^ptc.PU

(Slaninova et al., 2016)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible by esg^HMS00025, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by wg^JF01480, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by Btk^JF01797, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by fru^JF01182, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by lola^KK110256, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by Myc^JF01761, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by Myc^JF01762, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by chinmo^HMS00036, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by CycE^JF02473, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by fj^JF02843, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by Lk6^JF02993, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by upd1^JF03149, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by upd1^HMS00545, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by upd2^HMS00901, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by upd3^HMS00646, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by upd3^HM05061, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by upd3^KK110348, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by vg^GD1558, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by wg^KK108857, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible by sd^JF02514, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible by sd^KK108877, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by stg^HMS00146, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, suppressible | partially by esg^JF03134, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

NOT suppressed by

Statement

Reference

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, non-suppressible by ab^KK110195, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, non-suppressible by Cables1^KK109367, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, non-suppressible by magu^KK108507, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, non-suppressible by slow^KK102562, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

N^UAS.icd, Scer\GAL4^ptc-559.1 has hyperplasia phenotype, non-suppressible by upd2^HMS00948, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

Phenotype Manifest In

Suppressed by

Statement

Reference

N^UAS.icd, Scer\GAL4^ptc.PU has wing disc | third instar larval stage phenotype, suppressible | partially by Ldh^KK102330, Scer\GAL4^ptc.PU

(Slaninova et al., 2016)

N^UAS.icd, Scer\GAL4^ptc.PU has wing disc | third instar larval stage phenotype, suppressible | partially by Hex-A^KK100831, Scer\GAL4^ptc.PU

(Slaninova et al., 2016)

N^UAS.icd, Scer\GAL4^sca-C253 has mesothoracic tergum & macrochaeta phenotype, suppressible by btl::Egfr^λ.UAS, Scer\GAL4^sca-C253

(Hasson et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of ImpL3^KK102330 or Hex-A^KK100831 partially rescues the wing disc hyperplasia seen in larvae expressing N^Scer\UAS.icd under the control of Scer\GAL4^ptc.PU.

(Slaninova et al., 2016)

Coexpression of btl::Egfr^{Scer\UAS.T:λ\cI-DD} with N^Scer\UAS.icd, under the control of Scer\GAL4^sca-C253, suppresses the bristle-loss phenotype on the notum seen when N^Scer\UAS.icd alone is expressed.

(Hasson et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

N^Scer\UAS.icd

N^UAS.icd

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections