FB2024_03 , released June 25, 2024
Allele: Dmel\scb01288
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General Information
Symbol
Dmel\scb01288
Species
D. melanogaster
Name
FlyBase ID
FBal0007967
Feature type
allele
Associated gene
Dmel\scb
Associated Insertion(s)
P{PZ}scb01288
Carried in Construct
Also Known As
l(2)01288
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Stark et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{PZ}scb01288
Cytology
Description

P{PZ} insertion just 5' of the coding region for the shorter of the gene's two transcripts, 170bp upstream of the start Met.

(Stark et al., 1997)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant embryos show a reduced level of phagocytosis of apoptotic cells compared to controls.

      (Nonaka et al., 2013)

      Dorsal closure is incomplete in scb01288 embryos, which arrests cardial cell migration prior to closure of the heart vessel. Unlike in wild-type embryos, the cardial cells are adjacent to the aminoserosa during early and late development.

      (MacMullin and Jacobs, 2006)

      Embryos exhibit failure of dorsal closure. Some embryos undergo secondary closure and some of these hatch. Embryos show vigorous muscular movements of the cuticle, muscle attachment sites appear normal.

      (Stark et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      scb[+]/scb01288 is a suppressor of decreased occurrence of cell division phenotype of CycEJP

      (Brumby et al., 2004)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      scb01288 has embryo | dorsal closure stage phenotype, enhanceable by sli2/sli[+]

      (MacMullin and Jacobs, 2006)
      Enhancer of
      Statement
      Reference

      scb[+]/scb01288 is an enhancer of heart primordium phenotype of sli2

      (MacMullin and Jacobs, 2006)
      Suppressor of
      Statement
      Reference

      scb01288 is a suppressor of eye disc & S phase phenotype of CycEJP

      (Brumby et al., 2004)

      scb[+]/scb01288 is a suppressor of eye phenotype of CycEJP

      (Brumby et al., 2004)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      sli2/+, scb01288/+ embryos show delayed migration of cardial cells, contralaterally placed cardial cell nuclei and clumping of heart cells. Dorsal closure is delayed in these embryos but is complete at hatching.

      lea2/+, scb01288/+ embryos show a heart formation phenotype, including the appearance of contralaterally placed cardial cell nuclei.

      (MacMullin and Jacobs, 2006)

      Suppresses the S phase defects seen in the CycEJP eye disc.

      (Brumby et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Complements: chn02064.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      l(2)01288
      (Brumby et al., 2004, Spradling et al., 1999)
      l(2)0128801288
      scb01288
      (Dondi et al., 2021, Nonaka et al., 2013, Vanderploeg et al., 2012, Knox et al., 2011)
      scb1035
      (Stark et al., 1997)
      scb2,10288
      (MacMullin and Jacobs, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (16)