FlyBase Allele Report: Dmel\zip[02957]

(Hildebrand et al., 2021, Saja et al., 2010, Baumann, 2004, Vereshchagina et al., 2004, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, Perrimon et al., 1996)

visible (with zip^Ebr)

(Mizuno et al., 2002)

Phenotype Manifest In

embryonic/first instar larval cuticle | dorsal

(Perrimon et al., 1996)

eye (with zip^Ebr)

(Baumann, 2004)

pigment cell (with zip^Ebr)

(Baumann, 2004)

retina (with zip^Ebr)

(Baumann, 2004)

rhabdomere (with zip^Ebr)

(Baumann, 2004)

wing (with zip^Ebr)

(Baumann, 2004, Mizuno et al., 2002)

Detailed Description

Statement

Reference

About 70% of zip^Ebr/zip⁰²⁹⁵⁷ adults have malformed wings.

(Mizuno et al., 2002)

Some cells in homozygous clones in the wing have multiple F-actin prehairs.

(Winter et al., 2001)

Germline clones produce eggs with patterning defects: dorsal closure is defective. Lethality occurs during the embryonic and larval stages.

(Perrimon et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

zip⁰²⁹⁵⁷/zip^Ebr has visible phenotype, suppressible | partially by Mbs³/Mbs[+]

(Mizuno et al., 2002)

Enhancer of

Statement

Reference

zip[+]/zip⁰²⁹⁵⁷ is an enhancer of abnormal neuroanatomy phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Saja et al., 2010)

zip⁰²⁹⁵⁷ is an enhancer of visible phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

zip⁰²⁹⁵⁷ is an enhancer of abnormal cell polarity phenotype of S^48-5

(Gaengel and Mlodzik, 2003)

Suppressor of

Statement

Reference

zip[+]/zip⁰²⁹⁵⁷ is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^A9, Shrm^A.UAS

(Hildebrand et al., 2021)

zip[+]/zip⁰²⁹⁵⁷ is a suppressor | partially of decreased size | adult stage phenotype of Scer\GAL4^A9, Shrm^A.UAS

(Hildebrand et al., 2021)

zip[+]/zip⁰²⁹⁵⁷ is a suppressor of visible | adult stage phenotype of Scer\GAL4^lz-gal4, Shrm^A.UAS

(Hildebrand et al., 2021)

zip⁰²⁹⁵⁷ is a suppressor of lethal | male phenotype of flw⁶

(Vereshchagina et al., 2004)

zip⁰²⁹⁵⁷ is a suppressor of lethal | male phenotype of flw^G0172

(Vereshchagina et al., 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

zip⁰²⁹⁵⁷/zip^Ebr has wing phenotype, suppressible | partially by Mbs³/Mbs[+]

(Mizuno et al., 2002)

Enhancer of

Statement

Reference

zip[+]/zip⁰²⁹⁵⁷ is an enhancer of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Saja et al., 2010)

zip⁰²⁹⁵⁷ is an enhancer of eye phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

zip⁰²⁹⁵⁷ is an enhancer of ommatidium phenotype of S^48-5

(Gaengel and Mlodzik, 2003)

Suppressor of

Statement

Reference

zip[+]/zip⁰²⁹⁵⁷ is a suppressor of eye phenotype of Scer\GAL4^lz-gal4, Shrm^A.UAS

(Hildebrand et al., 2021)

zip[+]/zip⁰²⁹⁵⁷ is a suppressor | partially of wing phenotype of Scer\GAL4^A9, Shrm^A.UAS

(Hildebrand et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

A zip⁰²⁹⁵⁷/+ background enhances the visual system degeneration seen in Scer\GAL4^GMR.PF, Ppt1^Scer\UAS.cKa flies.

(Saja et al., 2010)

S^48-5/zip⁰²⁹⁵⁷ mutants show 34.60%+-4.71 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone.

(Gaengel and Mlodzik, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

zip^k15609

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11215

cn¹ P{PZ}zip⁰²⁹⁵⁷/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: l(2)00064⁰⁰⁰⁶⁴. Complements: Kr⁰⁰⁸⁹⁵. Complements: l(2)01848⁰¹⁸⁴⁸. Complements: l(2)10481⁰³²⁶³. Complements: Kr^k05826. Complements: mts^k12502.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

02957

(Kaltenbach et al., 2007)

Zip^P1215

(Hildebrand et al., 2021)

l(2)02957

(Spradling et al., 1999)

l(2)02957⁰²⁹⁵⁷

zip-02957

(Gaengel and Mlodzik, 2003)

zip⁰²⁹⁵⁷

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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