FlyBase Allele Report: Dmel\jumu[06439]

(Andrade et al., 2003.7.4, Dubruille et al., 2002, Vernooy et al., 2002, Cheah et al., 2000, Durand et al., 2000, Strodicke et al., 2000, Sugimura et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The cardial cells (CCs) are unevenly distributed in mutant embryos: hemisegments having localised increases or decreases in CC number, occasional enlarged CC nuclei and CCs that are misaligned either with other CCs within a hemisegment or with their counterparts across the dorsal midline are seen.

(Ahmad et al., 2012)

The number of SELK neurons is normal in jumu⁰⁶⁴³⁹ mutant animals.

(Losada-Pérez et al., 2010)

When jumu⁰⁶⁴³⁹ is added to W^GMR.PH, grim^GMR.PH or rpr^GMR.PH no effect is seen on the cell death phenotype in the eye.

(Vernooy et al., 2002)

Homozygous embryos occasionally show duplication of the RP2 neuron (expressivity of the phenotype is 4%).

(Cheah et al., 2000)

Dominant suppressor of PEV in In(1)w^m4.

(Strodicke et al., 2000)

jumu⁰⁶⁴³⁹ wing disc cell clones induced at late embryonic to early larval stages are much smaller than their sibling clones when examined in late third-instar larvae. Small mutant clones are detected in adult wing blades, but no mutant cells are found in the wing margin or bristles on the notum. In eye discs, small mutant clones are formed in the regions anterior to the morphogenetic furrow, while no mutant clones are detected posterior to the morphogenetic furrow or in the adult eye.

Approximately 95% of jumu⁰⁶⁴³⁹ embryos are defective in head involution, displaying an anterior open phenotype. Furthermore, about 35% of these flies show a defect in dorsal closure in addition the head involution defect. Incomplete germ band retraction is found in 20% of embryos. In jumu⁰⁶⁴³⁹ embryos, the dorsal epidermal cells only partially elongate. These embryos exhibit loss of a large number of both CNS and PNS neurons. Occasionally, all or most of the CNS neurons in a hemisegment are lost.

(Sugimura et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

jumu[+]/jumu⁰⁶⁴³⁹ is an enhancer of visible | adult stage phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

NOT Suppressor of

Statement

Reference

jumu⁰⁶⁴³⁹ is a non-suppressor of increased cell death phenotype of hid^GMR.PH

(Vernooy et al., 2002)

jumu⁰⁶⁴³⁹ is a non-suppressor of increased cell death phenotype of grim^GMR.PH

(Vernooy et al., 2002)

jumu⁰⁶⁴³⁹ is a non-suppressor of increased cell death phenotype of rpr^GMR.PH

(Vernooy et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

jumu[+]/jumu⁰⁶⁴³⁹ is an enhancer of eye phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

NOT Suppressor of

Statement

Reference

jumu⁰⁶⁴³⁹ is a non-suppressor of eye phenotype of hid^GMR.PH

(Vernooy et al., 2002)

jumu⁰⁶⁴³⁹ is a non-suppressor of eye phenotype of grim^GMR.PH

(Vernooy et al., 2002)

jumu⁰⁶⁴³⁹ is a non-suppressor of eye phenotype of rpr^GMR.PH

(Vernooy et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

jumu^06142a

(Dubruille et al., 2002)

jumu^06142a

(BDGP Project Members, 1994-1999)

Fails to complement

jumu^Hp126

(Sugimura et al., 2000)

jumu⁰⁵²⁹⁵

(BDGP Project Members, 1994-1999)

jumu⁰⁵²⁶⁴

(BDGP Project Members, 1994-1999)

jumu⁰⁴⁷⁴⁶

(BDGP Project Members, 1994-1999)

jumu⁰³⁶⁷⁶

(BDGP Project Members, 1994-1999)

Rescued by

jumu⁰⁶⁴³⁹ is rescued by jumu^hs.PS

(Strodicke et al., 2000)

Partially rescued by

jumu⁰⁶⁴³⁹ is partially rescued by jumu^UAS.cSa/Scer\GAL4^hs.PB

(Sugimura et al., 2000)

Comments

Expression of jumu^Scer\UAS.cSa at 25[o]C under the control of Scer\GAL4^hs.PB partially rescues the jumu⁰⁶⁴³⁹ phenotype, delaying the lethal phase from embryonic to larval stages.

(Sugimura et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11683

P{PZ}jumu⁰⁶⁴³⁹ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Excision of the P{PZ} element can revert both the lethality and the duplicated RP2 neuron phenotype.

(Cheah et al., 2000)

Fails to complement: stich1^EP359. Fails to complement: stich1^D233. Complements: Rfx²⁵³. Complements: l(3)A143.1F3^A143.1F3.

(Dubruille et al., 2002)

Complements: pnt^04877b. Complements: hth⁰⁶⁷⁶². Complements: l(3)j8B6^j8B6.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

Dom⁰⁶⁴³⁹

Dom^l(3)06439

(Strodicke et al., 2000)

Dwhn⁰⁶⁴³⁹

(Sugimura et al., 2000)

P1683

(Cheah et al., 2000)

jumu⁰⁶⁴³⁹

(Feuillette et al., 2020, Ahmad et al., 2012, Christensen et al., 2008.4.15)

jumu^11.683

(Herrero et al., 2014, Benito-Sipos et al., 2010, Losada-Pérez et al., 2010)

jumu¹¹⁶⁸³

(Losada-Pérez et al., 2010)

jumu⁶⁴³⁹

(Dubruille et al., 2002)

l(3)06439

(Spradling et al., 1999)

l(3)06439⁰⁶⁴³⁹

(Durand et al., 2000, BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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