FB2024_03 , released June 25, 2024
Allele: Dmel\rols08232
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General Information
Symbol
Dmel\rols08232
Species
D. melanogaster
Name
FlyBase ID
FBal0009607
Feature type
allele
Associated gene
Dmel\rols
Associated Insertion(s)
P{PZ}rols08232
Carried in Construct
Also Known As
l(3)08232, rolsP1729
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}rols08232
Cytology
Description

The insertion site of P{PZ}rols08232 maps to within 289bp of the transcriptional start of CG6793, which is located within a 26Kb intron of rols.

(Chen and Olson, 2001)

P{PZ} insertion in an intron shared by both the putative rols transcripts.

(Rau et al., 2001)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  alveolar rhabdomyosarcoma
      modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
      (Avirneni-Vadlamudi et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      While a wild-type DA1 myotube has an average of 15 nuclei at stage 15 (n = 70), its equivalent in embryos homozygous for rols08232 has an average of just 4 (n = 125).

      (Menon and Chia, 2001)

      Muscle number is reduced in homozygous embryos and many unfused myoblasts are seen. The pharynx shows fusion defects. Apodeme formation appears normal in mutant embryos.

      (Rau et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      rols[+]/rols08232 is an enhancer of visible | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Suppressor of
      Statement
      Reference

      rols[+]/rols08232 is a suppressor of lethal phenotype of Hsap\FOXO1::Hsap\PAX7UAS.cGa, Scer\GAL4Mhc.PW

      (Avirneni-Vadlamudi et al., 2012)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      rols[+]/rols08232 is an enhancer of eye | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Remobilisation of the P{PZ} element can restore viability.

      (Rau et al., 2001)

      Complements: l(3)0483604836. Complements: l(3)0508805088. Complements: l(3)j2D3j2D3. Complements: l(3)neo181.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      References (13)