FlyBase Allele Report: Dmel\HipHop[1]

General Information

Symbol

Dmel\HipHop¹

Species

D. melanogaster

Name

FlyBase ID

FBal0011040

Feature type

allele

Associated gene

Dmel\HipHop

Associated Insertion(s)

P{hsneo}HipHop¹

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Cooley et al., 1988)

Progenitor genotype

Associated Insertion(s)

P{hsneo}HipHop¹

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:18,821,191..18,821,191 [+]

(Dubruille et al., 2010, Spradling et al., 1999, Cooley et al., 1988)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(3L)BSC776)

(Dubruille and Loppin, 2015)

lethal | recessive

(Spradling et al., 1999, Cooley et al., 1988)

lethal - all die before end of first instar larval stage (with HipHop^EY07584)

(Dubruille et al., 2010)

some die during first instar larval stage (with HipHop^EY07584)

(Dubruille et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

All HipHop¹/HipHop^EY07584 animals die before the second larval stage.

(Dubruille et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

HipHop¹/HipHop^EY07584 has lethal | first instar larval stage phenotype, non-suppressible by ms(3)K81^{HipHop.cDa.GFP}

(Dubruille et al., 2010)

Enhancer of

Statement

Reference

HipHop¹/HipHop[+] is an enhancer of male semi-sterile phenotype of cav¹/Df(3R)Exel6198, cav^HipHop.GFP

(Dubruille and Loppin, 2015)

Other

Statement

Reference

Avic\GFP^RNAi.UAS.2, HipHop¹/Df(3L)BSC776, HipHop^GFP, Scer\GAL4^{VP16.nanos.UTR} has sterile phenotype

(Dubruille and Loppin, 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

HipHop¹/HipHop[+] is an enhancer of spermatid phenotype of cav¹/Df(3R)Exel6198, cav^HipHop.GFP

(Dubruille and Loppin, 2015)

HipHop¹/HipHop[+] is an enhancer of chromosome | adult stage | male phenotype of cav¹/Df(3R)Exel6198, cav^HipHop.GFP

(Dubruille and Loppin, 2015)

Other

Statement

Reference

Avic\GFP^RNAi.UAS.2, HipHop¹/Df(3L)BSC776, HipHop^GFP, Scer\GAL4^{VP16.nanos.UTR} has testis phenotype

(Dubruille and Loppin, 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The slightly reduced fertility of cav^{HipHop.T:Avic\GFP}/Y;cav¹/Df(3R)Exel6198 adult (cav¹ rescue) males is significantly enhanced by combination with Df(3R)ms(3)K81-2 and also by combination with HipHop¹ albeit less strongly. The fertility of cav^{HipHop.T:Avic\GFP}/Y;cav¹,Df(3R)ms(3)K81-2/HipHop¹,Df(3R)Exel6198 males is intermediate to that of cav^{HipHop.T:Avic\GFP}/Y;cav¹/Df(3R)Exel6198 males combined with either the Df(3R)ms(3)K81-2 or the HipHop¹ allele alone.

The increased number of abnormal spermatid nuclei (showing chromatin bridges) characteristic for adult cav^{HipHop.T:Avic\GFP};cav¹/Df(3R)Exel6198 males is strongly enhanced by combination with Df(3R)ms(3)K81-2 in homozygous or, to a lesser degree, in heterozygous state. Enhancement of the abnormal nuclear phenotype is also observed upon combination with single copy of HipHop¹ as well as ver^S147910 but the phenotype is not aggravated further by combination with heterozygous moi¹ allele.

(Dubruille and Loppin, 2015)

HipHop::ms(3)K81^{HipHop.T:Avic\GFP} does not suppress the lethality of HipHop¹/HipHop^EY07584.

(Dubruille et al., 2010)

Xenogenetic Interactions

Statement

Reference

Adult HipHop rescue males - HipHop^T:Avic\GFP;HipHop¹/Df(3L)BSC776 - expressing Avic\GFP^{dsRNA.shRNA.Scer\UAS.2} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} are sterile with severely atrophied testes.

(Dubruille and Loppin, 2015)

Complementation and Rescue Data

Rescued by

HipHop¹/Df(3L)BSC776 is rescued by HipHop^GFP

(Dubruille and Loppin, 2015)

HipHop¹/HipHop^EY07584 is rescued by HipHop^GFP

(Dubruille et al., 2010)

Comments

The lethality of HipHop¹/Df(3L)BSC776 flies is rescued by combination with HipHop^T:Avic\GFP.

(Dubruille and Loppin, 2015)

A copy of HipHop^T:Avic\GFP fully restores the viability of HipHop¹/HipHop^EY07584 mutants.

(Dubruille et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10264

mwh¹ P{hsneo}HipHop¹ red¹ e¹/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

Cooley et al.

(Cooley et al., 1988)

Comments

Complements: not⁰²⁰⁶⁹. Complements: W⁰⁵⁰¹⁴. Complements: Eip75B^rH705.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

HipHop¹

hiphop¹

(Dubruille and Loppin, 2015, Dubruille et al., 2010)

l(3)neo26

(Spradling et al., 1999)

l(3)neo26¹

(Christensen et al., 2009.5.6)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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