FB2024_03 , released June 25, 2024
Allele: Dmel\mor2
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General Information
Symbol
Dmel\mor2
Species
D. melanogaster
Name
FlyBase ID
FBal0012412
Feature type
allele
Associated gene
Dmel\mor
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)
Mutagen
ethyl methanesulfonate
(Kennison and Tamkun, 1988)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Clones induced early in development (24-48 hours after egg laying) are associated with small or absent halteres and the replacement of proximal haltere structures by proximal wing structures. Clones induced later (48-72 hours after egg laying) often lead to the absence or duplication of halteres, in addition to the appearance of wing structures in the haltere. Homozygous clones also cause transformation of the metanotum to mesonotum. Homozygous clones in the posterior wing cause distortions in wing shape; venation is disrupted and large socketed bristles appear along the posterior wing margin. Homozygous clones in the leg cause the femur and tibia to be short and twisted, and the tarsal segments to be enlarged. Leg clones also contain extra bristles. Clones in the anterior first leg are transformed to anterior second leg or have extra sex comb teeth. Clones in the second leg are twisted, have vesicles of extra tissue, or cause the absence of the entire leg. Tarsal segments are often fused, duplicated or absent. Clones in the third leg often have partial or complete duplications of distal structures, or the entire leg morphology is abnormal. Clones in the first and third legs often cause truncations of the leg. Eggs derived from homozygous germ-line clones fail to hatch and are very abnormal. These abnormalities include collapsed eggs, eggs with partial or no chorions, small or abnormally shaped eggs and fused and thick dorsal appendages.

      (Brizuela and Kennison, 1997)

      Mutation changes the level of w expression in ph-plac+3 flies; eye colour is lighter.

      (Fauvarque et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      mor2 is an enhancer of visible | dominant phenotype of tna1

      (Gutierrez et al., 2003)

      mor2 is an enhancer of visible phenotype of BacA\p35GMR.PH, DpGMR.PD, E2f1GMR.PD

      (Staehling-Hampton et al., 1999)
      Suppressor of
      Statement
      Reference

      mor2/mor[+] is a suppressor of visible | dominant phenotype of Snr1E1

      (Curtis et al., 2011)

      mor2 is a suppressor of visible | dominant | homeotic phenotype of Pcl10

      (Brizuela and Kennison, 1997)

      mor2 is a suppressor of visible | dominant | adult stage phenotype of Pcl10

      (Brizuela and Kennison, 1997)

      mor2 is a suppressor of visible | dominant phenotype of AntpNs

      (Brizuela and Kennison, 1997)

      mor2 is a suppressor of visible | dominant | homeotic phenotype of Pc4

      (Brizuela and Kennison, 1997)

      mor2 is a suppressor of visible | dominant | adult stage phenotype of Pc4

      (Brizuela and Kennison, 1997)

      mor2/mor[+] is a suppressor of visible | homeotic phenotype of AntpNs, Pc2

      (Kennison and Tamkun, 1988)
      NOT Suppressor of
      Statement
      Reference

      mor2 is a non-suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC

      (Maixner et al., 1998)
      Other
      Statement
      Reference

      γTub23CPl-2, mor2 has visible | dominant phenotype

      (Vázquez et al., 2008)

      brm2, mor2 has visible | dominant phenotype

      (Vazquez et al., 1999)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      mor2 is an enhancer of wing phenotype of tna1

      (Gutierrez et al., 2003)

      mor2/mor[+] is an enhancer of wing margin phenotype of Scer\GAL4en-e16E, shgUAS.cSa

      (Barker et al., 2001)

      mor2/mor[+] is an enhancer of wing blade posterior compartment phenotype of Scer\GAL4en-e16E, shgUAS.cSa

      (Barker et al., 2001)
      Suppressor of
      Statement
      Reference

      mor2/mor[+] is a suppressor of wing vein | ectopic phenotype of Snr1E1

      (Curtis et al., 2011)

      mor2/mor[+] is a suppressor of eye phenotype of armS56F.GMR

      (Barker et al., 2001)

      mor2 is a suppressor of mesothoracic leg phenotype of Pcl10

      (Brizuela and Kennison, 1997)

      mor2 is a suppressor of metathoracic leg phenotype of Pcl10

      (Brizuela and Kennison, 1997)

      mor2 is a suppressor of sex comb phenotype of Pcl10

      (Brizuela and Kennison, 1997)

      mor2 is a suppressor of antenna phenotype of AntpNs

      (Brizuela and Kennison, 1997)

      mor2 is a suppressor of mesothoracic leg phenotype of Pc4

      (Brizuela and Kennison, 1997)

      mor2 is a suppressor of metathoracic leg phenotype of Pc4

      (Brizuela and Kennison, 1997)

      mor2 is a suppressor of sex comb phenotype of Pc4

      (Brizuela and Kennison, 1997)

      mor2/mor[+] is a suppressor of antenna phenotype of AntpNs, Pc2

      (Kennison and Tamkun, 1988)
      Other
      Statement
      Reference

      γTub23CPl-2, mor2 has wing phenotype

      (Vázquez et al., 2008)

      brm2, mor2 has wing phenotype

      (Vazquez et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      γTub23CPl-2 results in a held-out wing phenotype in double heterozygous combination with mor2 (42% penetrance).

      (Vázquez et al., 2008)

      Enhances the phenotype of E2fGMR.PD DpGMR.PD BacA\p35GMR.PH flies.

      (Staehling-Hampton et al., 1999)

      brm2 shows some interaction in double heterozygous combination with mor2; slightly more than 20% of flies have held-out wings.

      (Vazquez et al., 1999)

      The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is not suppressed by mor2.

      (Maixner et al., 1998)

      Suppresses the antenna to leg transformation phenotype of Pc2, AntpNs/+. Causes between 50% and 100% suppression of the Pc4/+ extra sex combs phenotype.

      (Kennison and Tamkun, 1988)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mor2
      (Tian and Smith-Bolton, 2021, Curtis et al., 2011, Di Stefano et al., 2011, Vázquez et al., 2008, Chang et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (23)