Small deletion after the cdc10 repeats, resulting in termination of the protein.
Amino acid replacement: S2257G. Mutation is conservative. There is also a 16bp deletion removing T15442 to A15457 inclusive.
eye & neuron | somatic clone
macrochaeta & scutum
microchaeta & scutum
Wing notching is observed in 0% of N60g11/+ flies reared at 18 oC (with variable loss of bristles), in 30% of N60g11/+ flies reared at 25 oC (with no loss of bristles), and in 91% of N60g11/+ flies reared at 30 oC (with no loss of bristles).
More than 45% of flies with the capability to produce N60g11 somatic clones, reared at room temperature (approximately 22 oC) or above, show wing notching when recombination has been induced. The frequency of wing notching is slightly higher when flies are reared at 25 oC and 30 oC, and slightly lower when flies are reared at 18 oC.
Homozygous mutant clones in the adult eye show a loss of neurons.
Temperature-sensitive. Wing veins thickened with deltas at tips.
Hemizygotes die as embryos with holes in the ventral cuticle. Heterozygotes have an antineurogenic phenotype and have a reduced number of thoracic bristles compared to wild-type. This phenotype is suppressed in double heterozygous combination with Dp(1;2)51b.
Suppresses sensory organ precursor specification. Heterozygotes with NAx-9 exhibit a T-shaped pattern of mechanosensory bristles on the notum, due to bristle loss. Heterozygotes with a wild type chromosome show mild loss of microchaetae on the mesonotum.
Heterozygotes display a temperature-dependent dominant eye and wing phenotypes: at 21oC ommatidia are aberrantly arranged and wings are wild type and at 29oC eye phenotype is normal and wing display strong notching. Heterozygotes underproduce microchaetae at 21oC but produce wild type numbers at 29oC.
Male flies carrying Dp(1;2)51bV76e show wing-notching and lateral incisions, leg defects and tarsal reductions, missing or multiple bristles, missing or fused ocelli and variegated or roughened eyes, at varying frequencies.
Semilethal when heterozygous with Nnd-3.
At low temperature, heterozygous females have disordered eye facets and only mild wing nicking. At high temperatures, heterozygous females have normal eyes and strongly nicked wings. Most N60g11/N60g11; Dp(1;2)51b females survive when reared at 28-29oC, whereas at 20-22oC, their survival is less than 3%. The temperature sensitive period for lethality is monophasic and restricted to a relatively short interval in the middle of the embryonic stage.
Wings seldom notched; veins thickened; deltas at tips. N60g11/+ heterozygotes have normal eyes at 29oC and a disrupted facet arrangement at 21oC. With increasing temperature, rough eye phenotype diminishes and Notch mutant characteristics are expressed. TSP for disrupted facets is in the third instar. N60g11/N60g11 Dp(1;2)51b females are viable at 29oC; survival sharply decreased at 20-23oC; TSP for lethality in middle of embryonic stage. N60g11/fa flies have eyes like fa. Semilethal with Nnd-3. Viability poor with nd.
N60g11 has visible | dominant phenotype, suppressible by Df(3R)Delta-FX3
N60g11 has adult thoracic sensillum phenotype, suppressible by Df(3R)Delta-FX3
The N60g11/+ antineurogenic phenotype is suppressed in double heterozygous combination with Df(3R)Dl-FX3. Lethal in double heterozygous combination with wgS107.
The heterozygous loss of microchaetae phenotype is enhanced in a H1/+ background.
N+tCos479 rescues the embryonic lethality and therefore the neurogenic phenotype of homozygotes and the dominant wing notching phenotype of heterozygous females.
Ives.
Hypermorph or neomorph eye and bristle phenotype at low temperatures and loss of function at high temperatures. Dominant gain of function microchaetae phenotype at low temperatures. Mapped by genetic recombination to between NCo and Nnd-2.