FlyBase Allele Report: Dmel\N[+tCos479]

General Information

Symbol

Dmel\N^+tCos479

Species

D. melanogaster

Name

FlyBase ID

FBal0033811

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

cosP{479BE}

P{479BE}

Also Known As

N^cos479

Key Links

Genomic Maps

JBrowse

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Coyle-Thompson and Banerjee, 1993)

Progenitor genotype

Carried in construct

cosP{479BE}

P{479BE}

Cytology

Description

Included within Cosmid 479.

(Coyle-Thompson and Banerjee, 1993)

Allele components

Component

Use(s)

Regulatory region(s)

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

rescue_region

X:3,132,602..3,173,578 [+]

Linked to:

BglII-EcoRI restriction fragment

Comment:

Rescue fragment from hybrid cosmid containing DNA from BglII site at coordinate -12.3 and EcoR1 site at +12.3. Position of restriction fragment on reference sequence inferred by FlyBase curator.

(Ramos et al., 1989)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | embryonic stage

(Frankenreiter et al., 2021)

increased cell number | larval stage

(Frankenreiter et al., 2021)

wild-type

(Gu et al., 1995, Ramos et al., 1989)

Phenotype Manifest In

embryonic/larval crystal cell | embryonic stage | increased number

(Frankenreiter et al., 2021)

embryonic/larval crystal cell | increased number | larval stage

(Frankenreiter et al., 2021)

wing vein | adult stage

(Nagel et al., 2016)

Detailed Description

Statement

Reference

N^+tCos479/+ mutant flies display knotted vein phenotype with ectopic veinlets.

(Nagel et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

N^+tCos479 has wing vein | adult stage phenotype, enhanceable by CycG^HR7

(Nagel et al., 2016)

NOT Suppressor of

Statement

Reference

N^+tCos479 is a non-suppressor of wing phenotype of Scer\GAL4^32B, kuz^DN.UAS

(Qi et al., 1999)

N^+tCos479 is a non-suppressor of wing vein phenotype of Scer\GAL4^32B, kuz^DN.UAS

(Qi et al., 1999)

N^+tCos479 is a non-suppressor of eye phenotype of Scer\GAL4^32B, kuz^DN.UAS

(Qi et al., 1999)

N^+tCos479 is a non-suppressor of scutum & macrochaeta phenotype of Scer\GAL4^32B, kuz^DN.UAS

(Qi et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The vein knotting phenotype seen in N^+tCos479/+;CycG^HR7/+ mutants is enhanced in N^+tCos479/+;CycG^HR7/CycG^HR7 flies, more so in males than in females.

(Nagel et al., 2016)

An extra copy of N product provided by N^+tCos479 restores uniform size and normal hexagonal array of ommatidia top sno^71e3 mutants. The loss of photoreceptor cell phenotype is suppressed, though the mystery cell is still recruited as a photoreceptor. The extra copy of N also rescues the leg phenotype as well as the thick veins and notched blades of the wing.

(Coyle-Thompson and Banerjee, 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

N^+tCos479 rescues N^l93

(Gu et al., 1995)

N^+tCos479 rescues Df(1)N-54l9

(Ramos et al., 1989)

N^+tCos479 rescues N^60g11

(Ramos et al., 1989)

N^+tCos479 rescues N^fa-g

(Ramos et al., 1989)

N^+tCos479 rescues N^fa-swb

(Ramos et al., 1989)

N^+tCos479 rescues N^nd-1

(Ramos et al., 1989)

N^+tCos479 rescues N^nd-3

(Ramos et al., 1989)

N^+tCos479 rescues N^spl-1

(Ramos et al., 1989)

Partially rescues

N^+tCos479 partially rescues N^Ax-59b

(Ramos et al., 1989)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

N^+tCos479 can rescue the sterility of homozygous N^l1N-ts1 female flies kept at non-permissive temperatures, and can also rescue the reduction in fertility seen in male N^l1N-ts1 flies after exposure to non-permissive temperatures.

(Xu et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

N^+tCos479

N^cos479

(Frankenreiter et al., 2021, Nagel et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

Open Close