FB2024_03 , released June 25, 2024
Aberration: Dmel\Df(1)N-54l9
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General Information
Symbol
Df(1)N-54l9
Species
D. melanogaster
Name
Deficiency (1) Notch
FlyBase ID
FBab0000564
Feature type
chromosomal_deletion
Also Known As
N54l9, N5419, Df(1)N54l9, N54/9, Notch54l9, Df(1)N5419, Df(1)N-5419, Notch5419
Computed Breakpoints include

3C6;3C11

Features within 3C6--3C11
Sequence coordinates
X:3,240,926..3,242,094 [-] (Df(1)N-54l9:bk2)
(Furia et al., 1993)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
spontaneous
(Lefevre and Green, 1972)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Furia et al., 1993, Saumweber et al., 1990, McGinnis et al., 1980, Lefevre and Green, 1972, Lefevre, 1971)
Breakpoints

3C6;3C10

(McGinnis et al., 1980, Lefevre and Green, 1972)

3C5-3C6;3C11-3C12

(Saumweber et al., 1990)

3C5;3C10

(Furia et al., 1993)

3C6;3C11

(Lefevre, 1971)
Causes alleles
dnc54l9
(Qiu and Davis, 1993)
Carries alleles
Transposon Insertions
Formalized genetic data

rst << bk1 << vt << ng2 << bk2 << ng1

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

(Chen et al., 1986, McGinnis and Beckendorf, 1983, Perlman, 1983, Levis et al., 1982)

Lacks Sgs-4 sequences (McGinnis et al., 1980).

Comments on Cytology

Left limit of break 1 from polytene analysis (FBrf0023492) Right limit of break 1 from inclusion of vt (FBrf0023492) Left limit of break 2 from inclusion of ng2 (FBrf0058951) Right limit of break 2 from polytene analysis (FBrf0063630)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Complementation Data
 
Actn
(Kramers et al., 1991)
crm
(Kramers et al., 1991)
crn
(Kramers et al., 1991)
dwg
(Kramers et al., 1991)
ec
(Mohler, 1956)
egh
(Kramers et al., 1991)
gt
(Kramers et al., 1991)
kz
(Kramers et al., 1991)
l(1)2Dj
(Kramers et al., 1991)
l(1)2Dk
(Kramers et al., 1991)
l(1)2Dl
(Kramers et al., 1991)
l(1)2Dm
(Kramers et al., 1991)
l(1)2Ea
(Kramers et al., 1991)
l(1)2Ec
(Kramers et al., 1991)
l(1)2Ed
(Kramers et al., 1991)
l(1)2Fb
(Kramers et al., 1991)
l(1)2Fc
(Kramers et al., 1991)
l(1)2Fd
(Kramers et al., 1991)
l(1)2Ff
(Kramers et al., 1991)
l(1)2Fg
(Kramers et al., 1991)
l(1)3-64
(Kramers et al., 1991, Kramers et al., 1983)
l(1)3ABa
(Kramers et al., 1991)
l(1)3ABb
(Kramers et al., 1991)
l(1)3Aj
(Kramers et al., 1991)
l(1)3Ak
(Kramers et al., 1991)
l(1)3Al
(Kramers et al., 1991)
l(1)3Am
(Kramers et al., 1991)
l(1)3An
(Kramers et al., 1991)
l(1)3Ao
(Kramers et al., 1991)
l(1)3Ap
(Kramers et al., 1991)
l(1)3Aq
(Kramers et al., 1991)
l(1)3Bb
(Kramers et al., 1991)
l(1)3Bc
(Kramers et al., 1991)
l(1)3Bd
(Kramers et al., 1991)
l(1)3Bf
(Kramers et al., 1991)
l(1)3Bg
(Kramers et al., 1991)
l(1)3Da
(Kramers et al., 1991, Kramers et al., 1983)
l(1)3Eb
(Kramers et al., 1991, Kramers et al., 1983)
l(1)3Ed
(Kramers et al., 1991, Kramers et al., 1983)
l(1)7-103
(Kramers et al., 1991, Kramers et al., 1983)
l(1)EA65
(Kramers et al., 1991, Kramers et al., 1983)
l(1)ESHS14
(Kramers et al., 1991)
Myc
(Kramers et al., 1991, Kramers et al., 1983, Mohler, 1956)
ng1
(Furia et al., 1993)
Pgd
(Kramers et al., 1991)
Pi4KIIIα
(Kramers et al., 1991)
pn
(Kramers et al., 1991)
Raf
(Kramers et al., 1991)
rst
(Kramers et al., 1991, Kramers et al., 1983, Mohler, 1956)
sgg
(Kramers et al., 1991)
Sgs4
(McNabb and Beckendorf, 1986, McGinnis et al., 1980)
tko
(Kramers et al., 1991)
trol
(Kramers et al., 1991)
w
(Kramers et al., 1991, Kramers et al., 1983, Mohler, 1956)
wapl
(Kramers et al., 1991)
wds
(Kramers et al., 1991)
z
(Kramers et al., 1991)
Zw10
(Kramers et al., 1991)
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Lethal in male double hemizygous combination with Df(1)w67c3.

    (Lefevre and Green, 1972)

    Viable in combination with Df(1)w67k30, producing flies which have a strong vt phenotype, but are not rough eyed.

    (Lefevre, 1971)

    Df(1)N-54l9/Df(1)w67k30 viable Df(1)N-54l9/Df(1)w67k30 vt phenotype

    NOT in combination with other aberrations

    The wing notching phenotype of Df(1)N-54l9/+ heterozygotes is is largely suppressed if they are also heterozygous for any of the following: HattP, HΔM2, HΔM1-2 or HCfs but is not significantly altered by heterozygosity of Hcwt, HΔM1 or HΔM3.

    (Smylla et al., 2016)

    Flies heterozygous for Df(1)N-54l9 have a low penetrance wing notching phenotype.

    (Surabhi et al., 2015)

    Df(1)N-54l9 mutant germline stem cells (GSCs) do not undergo the natural turnover seen in wild type: at three weeks after clone induction more Df(1)N-54l9 mutant GSCs are still present in the female niche in comparison with wild type controls.

    (Tseng et al., 2014)

    Heterozygotes show a wing notching phenotype.

    (Groth et al., 2013)

    Df(1)N-54l9 embryos display hypertrophy of the central and peripheral nervous systems.

    Df(1)N-54l9/+ wings have a notched phenotype.

    (Lake et al., 2009)

    Df(1)N-54l9/+ females display a relatively weak notch-wing phenotype, characterised by wing vein thickening (preferentially L3 and L5) and by delta formation at the contact between wing veins and the wing edge. One or more notches is present in 75% of Df(1)N-54l9/+ wings.

    (Peralta et al., 2009)

    55% of Df(1)N-54l9/+ flies have a notched wing phenotype.

    (Kugler and Nagel, 2007)

    The number of cap cells and germline stem cells in the ovaries of 2 day old heterozygous females is significantly reduced compared to wild type.

    (Song et al., 2007)

    Df(1)N-54l9 heterozygotes exhibit notches at the wing margin.

    Df(1)N-54l9 Mer4; exe1 triple transheterozygous mutants suppress the Df(1)N-54l9 heterozygous wing notch phenotype.

    (Maitra et al., 2006)

    Clones of Df(1)N-54l9 mutant cells in the eye disc show a cell-autonomous block of mitosis and DNA synthesis in the position of the second mitotic wave (SMW). However, a small number of mutant cells do incorporate BrdU (a marker of S phase) in the most posterior regions of clones, significantly behind the SMW. Cell proliferation ahead of the morphogenetic furrow is not detectably impaired in Df(1)N-54l9 mutant cells.

    (Baonza and Freeman, 2005)

    Df(1)N-54l9 third instar nota clones exhibit at least eight sensory organ precursors (SOPs) in approximately 44.5% of SOP positions scored. Approximately 26% of SOP positions display between four and eight ectopic SOPs, while approximately 26% exhibit between one and four SOPs, with only 3.5% exhibiting one SOP, as in wild-type. Df(1)N-54l9 third instar nota clones exhibit a partially penetrant growth defect.

    (Pitsouli and Delidakis, 2005)

    Large Df(1)N-54l9 mutant clones in the eye disc (generated in a Minute/+ background) have very few or no neurons. Small clones (generated in a wild-type background) have extra neuronal cells. Basally located nuclei are found along the posterior margin of small clones.

    (Zhang et al., 2005)

    Neuronal development is impaired in when Df(1)N-54l9 is expressed in clones within the eye-antennal disc.

    (Kenyon et al., 2003)

    Visceral mesoderm is reduced in mutant embryos.

    (Duan et al., 2001)

    Non-muscle defects are seen in mutants.

    (Strunkelnberg et al., 2001)

    Heterozygous Df(1)N-54l9 flies exhibit a weakly-penetrant wing nicking phenotype.

    (Helms et al., 1999)

    Notches at the distal wing margin.

    (Fostier et al., 1998)

    No R8 cells or photoreceptor neurons develop in a N clone on the eye-disc.

    (Baker and Yu, 1997)

    Notching of the distal wing margin can be suppressed by osa308.

    (Treisman et al., 1997)

    Abnormal epidermal and muscle development. Presence of Scer\GAL4twi.PBa can normalise some but no all aspects of myogenesis in Df(1)N-54l9 mutants.

    (Baker and Schubiger, 1996)

    No effect on the faf eye phenotype.

    (Huang and Fischer-Vize, 1996)

    Suppression of the lethal SerBd-3 Ser+r83k combination, escapers exhibit phenotypically normal eyes and legs but lack halteres and had wing blades one half normal size.

    (Gu et al., 1995)

    Dominant enhancer of the scaMSKF mutant phenotype.

    (Hu et al., 1995)

    A few flies of the genotype Df(1)N-54l9,dxENU/+,dxENU;Su(dx)1/+ escape the lethality of their dead Df(1)N-54l9,dxENU/+,dxENU siblings. However they have the same, small, rough eye defect as their dead siblings.

    (Busseau et al., 1994)

    Heterozygotes show lethal interaction with gain of function Su(H) alleles.

    (Fortini and Artavanis-Tsakonas, 1994)

    The wing-notching phenotype of Df(1)N-54l9 heterozygotes is more severe in flies which also carry one or two copies of EgfrE3 or EgfrE1.

    (Baker and Rubin, 1992)

    cosP{479BE} construct rescues the embryonic lethality and therefore the neurogenic phenotype of homozygotes and the dominant wing notching phenotype of heterozygous females.

    (Ramos et al., 1989)

    Puff formation at 3C11 during intermoult period.

    (McNabb and Beckendorf, 1986)

    Homozygous males are lethal.

    (Lefevre and Green, 1972)

    Weak Notch. Deltas of long veins reliable in classification when wing tips not notched.

    Stocks (1)
    Notes on Origin
    Discoverer

    Mohler, 9th Dec. 1954.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (12)
    Reported As
    Symbol Synonym
    Df(1)-N5419
    (Nagel et al., 2016)
    Df(1)N-5419
    (Praxenthaler et al., 2015, Weber et al., 2012)
    Df(1)N-54l9
    Df(1)N5419
    (Smylla et al., 2016, Kugler and Nagel, 2010, Weavers et al., 2009)
    Df(1)N54l9
    (Kuan et al., 2009, Peralta et al., 2009, Strunkelnberg et al., 2001, Hing et al., 1994, Nighorn et al., 1994, Furia et al., 1993, Qiu and Davis, 1993, Saumweber et al., 1990, McNabb and Beckendorf, 1986, Welshons and Welshons, 1986, Kramers et al., 1983, McGinnis et al., 1980, Lefevre and Green, 1972)
    DfN54l9
    (Kramers et al., 1991)
    N54/9
    (Kim et al., 2017, Baonza and Freeman, 2005, Kenyon et al., 2003, Baonza and Freeman, 2001, Lee et al., 2000)
    N5419
    (Nagel et al., 2021, Pandey et al., 2018, Nagel et al., 2016, Smylla et al., 2016, Praxenthaler et al., 2015, Tseng et al., 2014, Cho and Fischer, 2011, Seugnet et al., 2011, Beam and Moberg, 2010, Kugler and Nagel, 2010, Tien et al., 2008, Kankel et al., 2007, Kugler and Nagel, 2007, Müller et al., 2005, Reynolds-Kenneally and Mlodzik, 2005, Johannes and Preiss, 2002, Duan et al., 2001, Morel and Schweisguth, 2000, Helms et al., 1999, Treisman et al., 1997, Schmid et al., 1996, Baker and Rubin, 1992)
    N54l9
    (Pandey et al., 2019, Sachan et al., 2015, Surabhi et al., 2015, Mishra et al., 2014, Groth et al., 2013, Haase Gilbert et al., 2013, Lee et al., 2013, Leonardi et al., 2011, Monastirioti et al., 2010, Lake et al., 2009, Song et al., 2007, Fuwa et al., 2006, Maitra et al., 2006, Pitsouli and Delidakis, 2005, Baron et al., 2000, Cornell et al., 1999, Ligoxygakis et al., 1999, Ye and Fortini, 1999, Fostier et al., 1998, Baker and Yu, 1997, Baker and Schubiger, 1996, Cadigan and Nusse, 1996, Huang and Fischer-Vize, 1996, Sun and Artavanis-Tsakonas, 1996, Gu et al., 1995, Hu et al., 1995, Busseau et al., 1994, Lefevre, 1971)
    Notch5419
    (Kannan et al., 2018, Yang et al., 2015)
    Notch54l9
    (Monastirioti et al., 2010, Sasaki et al., 2007, Zhang et al., 2005)
    Name Synonyms
    Deficiency (1) Notch
    Secondary FlyBase IDs
    • FBal0038924
    • FBab0023986
    References (88)