FlyBase Allele Report: Dmel\N[nd-1]

Contains both the the 41 bp deletion within the N coding region described by Harding-Theobald et al. 2007 (FBrf0195930) and the mutation present in the progenitor N^nd-1-dse chromosome (T9408C substitution within the Downstream Sequence Element (DSE) of the consensus polyadenylation site).

(Shepherd et al., 2009)

41bp deletion at the 3' end of the 8th exon, within the intracellular domain. The deleted nucleotides, as determined by sequencing genomic DNA, are CGGTTCAGCGGGCTTGGACCTGAATGGATTTTGTGGATCTC.

(Harding-Theobald et al., 2007.2.6)

Amino acid replacement: T1561S. An extra Q is inserted between the Q amino acids at position 2567 and 2568.

(Lyman and Young, 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:3,170,516..3,170,556 [+]

Comment:

Reported as a 41 nucleotide deletion at the 3' end of the 8th exon. The sequence of the 41 deleted nucleotides was reported. The strain also contains the T to C mutation in the N 3' UTR present in the progenitor N^nd-1-dse chromosome.

(Harding-Theobald et al., 2007.2.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye | heat sensitive

(Shellenbarger and Mohler, 1975)

eye | temperature conditional

(Park et al., 2007, Indrasamy et al., 2000)

macrochaeta | cell non-autonomous

(Heitzler and Simpson, 1993)

ommatidium | heat sensitive

(Shellenbarger and Mohler, 1975)

orbital bristle

(Indrasamy et al., 2000)

tarsal segment 4 & joint | ectopic

(Mazaleyrat et al., 2003)

wing

(Tenney et al., 2006, Tsuda et al., 2002, Helms et al., 1999, Rollins et al., 1999, Royet et al., 1998, Hart et al., 1993, Rabinow and Birchler, 1990, Ramos et al., 1989)

wing | heat sensitive

(Shellenbarger and Mohler, 1975)

wing | temperature conditional

(Park et al., 2007)

wing blade

(Gause et al., 2006)

wing blade | temperature conditional

(Indrasamy et al., 2000)

wing margin

(Marygold et al., 2011, Olswang-Kutz et al., 2009, Bejarano et al., 2008, Alexander et al., 2006, Gause et al., 2006, Tenney et al., 2006, Eissenberg et al., 2005)

wing vein

(Marygold et al., 2011, Cornell et al., 1999, Royet et al., 1998, Matsuno et al., 1995, Lyman and Young, 1993)

wing vein | heat sensitive

(Shellenbarger and Mohler, 1975)

wing vein | temperature conditional

(Indrasamy et al., 2000)

Detailed Description

Statement

Reference

N^nd-1 mutant flies exhibit significantly enhanced 24 hour long-term memory formation.

(Zhang et al., 2013)

N^nd-1 hemizygous males have notched wings and thickened wing veins.

(Marygold et al., 2011)

N^nd-1 mutant flies display a notched-wing phenotype.

(Olswang-Kutz et al., 2009)

At 18[o]C the eyes of N^nd-1 mutant adults are only slightly smaller and rougher than wild-type, moderate notching of the wing margin is also observed.

(Park et al., 2007)

Male flies hemizygous for N^nd-1 show wings with minor margin nicking.

(Alexander et al., 2006)

Mutants show gaps in the wing margin and reduced wing blade size.

(Gause et al., 2006)

N^l1N-ts1/N^nd-1 adults are produced at the permissive temperature.

(Micchelli and Perrimon, 2006)

N^nd-1 causes limited nicking in the margin of the adult wing.

(Tenney et al., 2006)

N^nd-1/Y animals have extra joint material in the tarsal segment 4 but not in segment 3.

(Mazaleyrat et al., 2003)

N^nd-1 mutants have notched wings.

(Eissenberg et al., 2002)

N^nd-1 is a temperature-sensitive allele. In homozygous N^nd-1 mutants at 29[o]C, eyes are rough and reduced in size. They also exhibit extreme wing notching and thickened wing veins.

N^nd-1 mutants show significantly reduced mean character size for orbital bristles compared to Canton-S flies.

(Indrasamy et al., 2000)

Wings show a cut phenotype, similar to that of ct^53d.

(Rollins et al., 1999)

Wing margin is scalloped. Wing veins are slightly thickened. Phenotype suggests loss of function effect in one context (wing margin formation) and gain of function effect in another (wing vein formation).

(Royet et al., 1998)

Homozygotes exhibit a weak N loss of function phenotype, having notched wings. This phenotype is fully penetrant but slightly variable.

(Hart et al., 1993)

Mutant flies show a weak loss of function phenotype and produce a slight excess of neural cells. Mutant cells in clones can influence their neighbours since fewer than expected wild type bristles are found along the mosaic borders.

(Heitzler and Simpson, 1993)

Thickened wing veins with deltas and variably notched wing margins.

(Lyman and Young, 1993)

Thick wing veins, wing nicks along the apical, anterior and posterior margins.

(Gorman and Girton, 1992)

Notching of the wing tip at 25^oC.

(Jack and DeLotto, 1992)

The haplo-insufficient phenotype in the mesonotum is an increase in microchaetae density when N^nd-1 and N^nd-3 are in combination with N amorph alleles.

(de Celis et al., 1991)

Wing notches in the adult. Ser^D/N^nd-1 transheterozygotes display a synergistic phenotype: loss of anterior and posterior wing margins and loss if distal wing blade tissue. N^nd-1/Df(3R)Bd males exhibit a significantly increased mutant wing phenotype compared to N^nd-1 alone.

(Fleming et al., 1990)

Homozygous wing margins are excised. Wing phenotype can be enhanced in severity by vg and sca mutations. Phenotype can be suppressed by extra copies of sca⁺ and vg⁺.

(Rabinow and Birchler, 1990)

N^nd-1/dx^ENU and N^nd-2/dx^ENU transheterozygous flies never reach adulthood, stage not determined. Enhance wing phenotype.

(Xu and Artavanis-Tsakonas, 1990)

N/N^nd-1 heterozygotes are partially viable and relatively infertile.

(Portin, 1977)

Homozygotes have slightly small, rough eyes, extreme apical and marginal notches in the wing and thick wing veins at 29^oC. At 25^oC, the eyes are weakly rough, notches are seen in the wing and the wing veins are thick. At 18^oC, the eyes are normal and the wings have weak nicks.

(Shellenbarger and Mohler, 1975)

Similar to and phenotypically non-complementary with N^nd-3. Semilethal when heterozygous with dominant visible alleles of N : survivors are relatively infertile.

(Welshons, 1974)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

N^nd-1 has visible phenotype, enhanceable by Pcif1^EY11352/CG11399[+]

(Bejarano et al., 2008)

N^nd-1 has visible | adult stage | temperature conditional phenotype, enhanceable by jigr1[+]/jigr1²²⁰⁵

(Park et al., 2007)

N^nd-1 has visible phenotype, enhanceable by RpL13A^EP3614.A

(Alexander et al., 2006)

N^nd-1 has visible phenotype, enhanceable by Rtf1^RNAi.Sym.UAS/Scer\GAL4^hs.PB

(Tenney et al., 2006)

N^nd-1 has visible phenotype, enhanceable by dom⁷

(Eissenberg et al., 2005)

NOT Enhanced by

Statement

Reference

N^nd-1 has visible phenotype, non-enhanceable by EloA^RNAi.Sym.UAS/Scer\GAL4^hs.PB

(Tenney et al., 2006)

Enhancer of

Statement

Reference

N^nd-1 is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

N^nd-1 is an enhancer of visible phenotype of Rbf^280.UAS, Scer\GAL4^bbg-C96

(Kwon et al., 2013)

N^nd-1 is an enhancer of partially lethal - majority die phenotype of Past1^60-4

(Olswang-Kutz et al., 2009)

N^nd-1 is an enhancer of short lived phenotype of Past1^60-4

(Olswang-Kutz et al., 2009)

N^nd-1 is an enhancer of partially lethal - majority die phenotype of Past1^110-1

(Olswang-Kutz et al., 2009)

N^nd-1 is an enhancer of short lived phenotype of Past1^110-1

(Olswang-Kutz et al., 2009)

N^nd-1 is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

Suppressor of

Statement

Reference

N[+]/N^nd-1 is a suppressor of visible | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

Other

Statement

Reference

N^nd-1, e(r)^p2 has lethal phenotype

(Tsubota et al., 2011)

N^nd-1, e(r)^27-1 has lethal phenotype

(Tsubota et al., 2011)

N^nd-1, e(r)^p2 has viable phenotype

(Tsubota et al., 2003)

N^nd-1, Su(dx)³² has visible | recessive phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp has visible | recessive phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp/Su(dx)[+], dx^S1M has lethal phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp/Su(dx)³², dx^S1M has visible phenotype

(Cornell et al., 1999)

N^nd-1, hryⁱ²² has visible | dominant phenotype

(Abu-Issa and Cavicchi, 1996)

N^nd-1, vg^s2 has visible | recessive phenotype

(Abu-Issa and Cavicchi, 1996)

N^nd-1, hryⁱ²² has visible | recessive phenotype

(Abu-Issa and Cavicchi, 1996)

Phenotype Manifest In

Enhanced by

Statement

Reference

N^nd-1 has wing margin phenotype, enhanceable by E-2g[+]/ebi^2g1

(Marygold et al., 2011)

N^nd-1 has wing vein phenotype, enhanceable by E-2g[+]/ebi^2g1

(Marygold et al., 2011)

N^nd-1 has wing margin phenotype, enhanceable by Past1^60-4

(Olswang-Kutz et al., 2009)

N^nd-1 has wing phenotype, enhanceable by Past1^110-1

(Olswang-Kutz et al., 2009)

N^nd-1 has wing margin phenotype, enhanceable by Pcif1^EY11352/CG11399[+]

(Bejarano et al., 2008)

N^nd-1 has eye | temperature conditional phenotype, enhanceable by jigr1[+]/jigr1²²⁰⁵

(Park et al., 2007)

N^nd-1 has wing | temperature conditional phenotype, enhanceable by jigr1[+]/jigr1²²⁰⁵

(Park et al., 2007)

N^nd-1 has wing margin phenotype, enhanceable by RpL13A^EP3614.A

(Alexander et al., 2006)

N^nd-1 has wing blade phenotype, enhanceable by Nipped-A[+]/Nipped-A³²³

(Gause et al., 2006)

N^nd-1 has wing blade phenotype, enhanceable by Nipped-A[+]/Nipped-A^NC96

(Gause et al., 2006)

N^nd-1 has wing blade phenotype, enhanceable by Nipped-A[+]/Nipped-A^NC106

(Gause et al., 2006)

N^nd-1 has wing blade phenotype, enhanceable by Nipped-A[+]/Nipped-A^NC186

(Gause et al., 2006)

N^nd-1 has wing blade phenotype, enhanceable by Nipped-A[+]/Nipped-A^NC194

(Gause et al., 2006)

N^nd-1 has wing blade phenotype, enhanceable by dom^k08108

(Gause et al., 2006)

N^nd-1 has wing phenotype, enhanceable by Rtf1^RNAi.Sym.UAS/Scer\GAL4^hs.PB

(Tenney et al., 2006)

N^nd-1 has wing margin phenotype, enhanceable by dom⁷

(Eissenberg et al., 2005)

N^nd-1 has tarsal segment & joint | ectopic phenotype, enhanceable by Su(dx)^sp

(Mazaleyrat et al., 2003)

N^nd-1 has tarsal segment 4 & joint | ectopic phenotype, enhanceable by Su(dx)^sp

(Mazaleyrat et al., 2003)

N^nd-1 has wing margin phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)¹⁰

(Eissenberg et al., 2002)

N^nd-1 has wing margin phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)¹⁷

(Eissenberg et al., 2002)

N^nd-1 has wing margin phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)^S-192

(Eissenberg et al., 2002)

N^nd-1 has wing margin phenotype, enhanceable by Su(Tpl)^XS-706/Su(Tpl)[+]

(Eissenberg et al., 2002)

N^nd-1 has wing margin phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)^s1

(Eissenberg et al., 2002)

N^nd-1 has wing phenotype, enhanceable by ebi^E4

(Tsuda et al., 2002)

N^nd-1 has wing vein phenotype, enhanceable by Su(dx)^UAS.cCa/Scer\GAL4^Bx-MS1096

(Cornell et al., 1999)

N^nd-1 has wing phenotype, enhanceable by Su(dx)^UAS.cCa/Scer\GAL4^Bx-MS1096

(Cornell et al., 1999)

N^nd-1 has wing phenotype, enhanceable by Df(2R)Nipped-D341.1

(Rollins et al., 1999)

N^nd-1 has wing phenotype, enhanceable by Df(2R)Nipped-E338

(Rollins et al., 1999)

N^nd-1 has wing phenotype, enhanceable by Nipped-A^222.3

(Rollins et al., 1999)

N^nd-1 has wing phenotype, enhanceable by RpL38^45-72

(Rollins et al., 1999)

N^nd-1 has wing phenotype, enhanceable by Chi^e5.5

(Rollins et al., 1999)

N^nd-1 has wing phenotype, enhanceable by vg¹

(Rollins et al., 1999)

N^nd-1 has wing phenotype, enhanceable by Su(H)¹⁶

(Rollins et al., 1999)

N^nd-1 has wing phenotype, enhanceable by Su(H)[+]/Su(H)²

(Royet et al., 1998)

N^nd-1 has wing vein phenotype, enhanceable by Su(H)[+]/Su(H)²

(Royet et al., 1998)

N^nd-1 has wing phenotype, enhanceable by Su(H)[+]/Su(H)¹⁶

(Fortini and Artavanis-Tsakonas, 1994)

N^nd-1 has phenotype, enhanceable by sno^71e3

(Coyle-Thompson and Banerjee, 1993)

N^nd-1 has wing phenotype, enhanceable by RpL19^P

(Hart et al., 1993)

N^nd-1 has wing phenotype, enhanceable by Df(2R)ES1

(Hart et al., 1993)

N^nd-1 has wing phenotype, enhanceable by Df(2R)M60E

(Hart et al., 1993)

N^nd-1 has wing phenotype, enhanceable by RpL19^ex1

(Hart et al., 1993)

N^nd-1 has wing phenotype, enhanceable by RpL19^ex16

(Hart et al., 1993)

N^nd-1 has wing phenotype, enhanceable by RpL19^ex51

(Hart et al., 1993)

N^nd-1 has wing phenotype, enhanceable by RpS5a²

(Hart et al., 1993)

N^nd-1 has wing phenotype, enhanceable by Df(3R)M86D

(Hart et al., 1993)

NOT Enhanced by

Statement

Reference

N^nd-1 has wing blade phenotype, non-enhanceable by Nipped-A[+]/Nipped-A^NC105

(Gause et al., 2006)

N^nd-1 has wing blade phenotype, non-enhanceable by Ada2b[+]/Ada2b^HD-5

(Gause et al., 2006)

N^nd-1 has wing blade phenotype, non-enhanceable by Ada2b[+]/Ada2b¹

(Gause et al., 2006)

N^nd-1 has wing blade phenotype, non-enhanceable by Ada2b[+]/Ada2b²

(Gause et al., 2006)

N^nd-1 has wing phenotype, non-enhanceable by EloA^RNAi.Sym.UAS/Scer\GAL4^hs.PB

(Tenney et al., 2006)

N^nd-1 has phenotype, non-enhanceable by Su(H)⁸

(Rollins et al., 1999)

N^nd-1 has phenotype, non-enhanceable by ap^56f

(Rollins et al., 1999)

N^nd-1 has phenotype, non-enhanceable by l(2)41Ae³⁴

(Rollins et al., 1999)

Suppressed by

Statement

Reference

N^nd-1 has wing phenotype, suppressible by Nipped-B⁴⁰⁷

(Rollins et al., 1999)

N^nd-1 has wing phenotype, suppressible by Nipped-B^292.1

(Rollins et al., 1999)

N^nd-1 has wing phenotype, suppressible by Nle[+]/Nle^k13714

(Royet et al., 1998)

N^nd-1 has wing vein phenotype, suppressible by Nle[+]/Nle^k13714

(Royet et al., 1998)

N^nd-1 has wing phenotype, suppressible by Nle[+]/Nle^Δ8

(Royet et al., 1998)

N^nd-1 has wing vein phenotype, suppressible by Nle[+]/Nle^Δ8

(Royet et al., 1998)

Enhancer of

Statement

Reference

N^nd-1 is an enhancer of wing margin phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

N^nd-1 is an enhancer of wing margin phenotype of Rbf^280.UAS, Scer\GAL4^bbg-C96

(Kwon et al., 2013)

N^nd-1 is an enhancer of wing phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

N^nd-1 is an enhancer of wing margin bristle phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

N^nd-1 is an enhancer of phenotype of sno^71e3

(Coyle-Thompson and Banerjee, 1993)

Suppressor of

Statement

Reference

N[+]/N^nd-1 is a suppressor of wing vein | ectopic | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

N[+]/N^nd-1 is a suppressor of wing | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

Other

Statement

Reference

N^nd-1, Su(dx)^sp has tarsal segment 3 & joint | ectopic phenotype

(Mazaleyrat et al., 2003)

N^nd-1, Su(dx)³² has wing vein L2 phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)³² has wing vein L5 phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)³² has wing vein L3 phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)³² has wing vein L4 phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp has wing vein L2 phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp has wing vein L5 phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp has wing vein L3 phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp has wing vein L4 phenotype

(Cornell et al., 1999)

N^nd-1, Su(dx)^sp/Su(dx)³², dx^S1M has wing vein phenotype

(Cornell et al., 1999)

N^nd-1, vg^s2 has wing phenotype

(Abu-Issa and Cavicchi, 1996)

N^nd-1, hryⁱ²² has wing phenotype

(Abu-Issa and Cavicchi, 1996)

N^nd-1, Su(dx)¹, dx^ENU has wing phenotype

(Busseau et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

The wing nicking phenotype caused by expression of dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96 is enhanced if the flies are also carrying N^nd-1/Y.

The wing nicking phenotype caused by expression of Rbf^280.Scer\UAS under the control of Scer\GAL4^bbg-C96 is enhanced if the flies are also carrying N^nd-1.

(Kwon et al., 2013)

Heterozygosity for ebi^2g1 enhances the notched wing margin and thickened wing vein phenotypes seen in N^nd-1 hemizygous males.

(Marygold et al., 2011)

N^nd-1, Past1^60-4 double homozygous flies reach adulthood at a very low frequency, and die after 1 day. The wings are more severely notched compared to N^nd-1 mutant flies.

N^nd-1, Past1^110-1 double homozygous flies reach adulthood at a very low frequency, and die after 1 day. The wings are more severely notched compared to N^nd-1 mutant flies.

(Olswang-Kutz et al., 2009)

The slightly reduced eye size and moderate wing margin nicking observed in the temperature-sensitive N^nd-1 homozygous adults at 18[o]C is enhanced by wg^Gla-1 heterozygosity: the ventral half of the adult eye is virtually completely lost and the wing notching phenotype is exacerbated too.

(Park et al., 2007)

Wings from male flies hemizygous for N^nd-1 and heterozygous for RpL13A^EP3614.A show a severe loss of wing material compared to N^nd-1/Y wings, whereas wings from RpL13A^EP3614.A heterozygotes appear wild type.

(Alexander et al., 2006)

Heterozygosity for Nipped-A³²³, Nipped-A^NC96, Nipped-A^NC106, Nipped-A^NC186, Nipped-A^NC194 or dom^k08108 further reduces the width of N^nd-1 wings.

(Gause et al., 2006)

Co-expression of Rtf1^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^hs.PB at 27[o]C significantly decreases the width of N^nd-1 wings relative to controls.

(Tenney et al., 2006)

dom⁷ enhances the wing nicking phenotype of N^nd-1.

(Eissenberg et al., 2005)

N^nd-1/Y, Su(dx)^sp have extra, reversed polarity joints in tarsal segments three and four.

(Mazaleyrat et al., 2003)

Wing notching in N^nd-1 mutants is enhanced by heterozygosity for Su(Tpl)^s1, Su(Tpl)¹⁷, Su(Tpl)^XS-706, Su(Tpl)¹⁰, or Su(Tpl)^S-192.

(Eissenberg et al., 2002)

The wing notching phenotype seen in hemizygous N^nd-1 animals is enhanced by the addition of ebi^E4.

(Tsuda et al., 2002)

Wing vein thickening is enhanced by Su(dx)^Scer\UAS.cCa driven by Scer\GAL4^Bx-MS1096. Wing margin loss and wing size reduction are also evident.

(Cornell et al., 1999)

N^nd-1/Y flies exhibit a minor wing nicking phenotype, and strongly enhance the wing nicking phenotype seen in mam^N.Scer\UAS, Scer\GAL4^C96 flies.

(Helms et al., 1999)

l(2)41Ae⁷, ap^56f and Su(H)⁸ have little or no effect on the N^nd-1 cut wing phenotype.

(Rollins et al., 1999)

N^nd-1/Y; vg^s2/vg^s2 flies show notching of the wing. N^nd-1/Y; hⁱ²²/+ flies have severe notching of the wings.

(Abu-Issa and Cavicchi, 1996)

Notched wing phenotype dominantly enhanced by Su(H)¹⁶.

(Fortini and Artavanis-Tsakonas, 1994)

Synergistic interaction of phenotype with that of sno^71e3 mutation.

(Coyle-Thompson and Banerjee, 1993)

The N^nd-1 wing phenotype is enhanced by one copy of RpL19^P, Df(2R)ES1 or Df(2R)M60E. The wing notching phenotype is also enhanced by RpL19^ex1, RpL19^ex16, RpL19^ex51 RpS5a² and Df(3R)M86D, M(2)201¹ and RpS17⁴.

(Hart et al., 1993)

Additive interactions with dx alleles.

(Gorman and Girton, 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

N^fa-g

(Shellenbarger and Mohler, 1975)

N^fa-1

(Shellenbarger and Mohler, 1975)

N^Ax-tsl

(Shellenbarger and Mohler, 1975)

N^spl-1

(Shellenbarger and Mohler, 1975)

N^l1N-ts2

(Shellenbarger and Mohler, 1975)

N^l1N-ts1

(Shellenbarger and Mohler, 1975)

Fails to complement

N^nd-p

(Tsubota et al., 2003)

N^Ax-tsl

(Shellenbarger and Mohler, 1975)

N^l1N-ts2

(Shellenbarger and Mohler, 1975)

N^l1N-ts1

(Shellenbarger and Mohler, 1975)

Rescued by

N^nd-1 is rescued by N^mMGIIa

(Ramos et al., 1989)

N^nd-1 is rescued by N^+tCos479

(Ramos et al., 1989)

Comments

cosP{479BE} and P{MGIIa} constructs rescue the mutant wing phenotype. Presence of the construct confers a Confluens phenotype indicative of supernumerary copies of N.

(Ramos et al., 1989)

Complementation is at 29^oC.

(Shellenbarger and Mohler, 1975)

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (1)

Bloomington

2209

N^nd-1 rb¹

Notes on Origin

Discoverer

A 'N[nd-1]' stock obtained from Spyros Artavanis-Tsakonas (termed 'SAT N[nd-1]') was found to contain a mixture of two different chromosomes: (i) the N^nd-1-dse mutation alone (at relatively low frequency); and (ii) the N^nd-1-dse mutation together with the 41 bp deletion within the N coding region described by Harding-Theobald et al. 2007 (FBrf0195930). A 'N[nd-1]' stock obtained from the Drosophila Stock Center (termed 'DSC N[nd-1]') contains only the chromosome containing both lesions. The N^nd-1-dse lesion appears to have been the original mutation, with 'N[nd-1]' flies originally containing this mutation alone. However, the chromosome containing both the N^nd-1-dse lesion and the 41 bp deletion within the N coding region has almost completely displaced the original chromosome in the 'SAT N[nd-1]' stock and has completely displaced it in the 'DSC N[nd-1]' stock.

(Shepherd et al., 2009)

Comments

FlyBase curator comment: The 'N[nd-1]' stock has been found to have acquired a second mutation in N over time (see FBrf0209477 for details). The N^nd-1-dse lesion (mutation in the Downstream Sequence Element of the consensus polyadenylation site) appears to have been the original mutation, with a 41 bp deletion within the N coding region occurring later. Data in FlyBase curated from individual papers using 'N[nd-1]' have been retained under the N[nd-1] allele record (FBal0012890), which represents the double mutant chromosome, unless it is clear that the chromosome being studied contains only the original lesion, in which case the data has been moved to the N^nd-1-dse allele record (FBal0282136). It is thus possible that some of the papers and curated data listed under N[nd-1] in FlyBase (especially information from older papers) describe experiments carried out using the N^nd-1-dse chromosome, but there is insufficient information to be sure. (date: 130225).

(FlyBase, 1992-)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

N^ND1

(Bejarano et al., 2008)

N^nd-1

(Morimoto et al., 2016, Marygold et al., 2011, Tsubota et al., 2011, Popodi et al., 2010-, Olswang-Kutz et al., 2009, Harding-Theobald et al., 2007.2.6, Gause et al., 2006, Tenney et al., 2006, Eissenberg et al., 2005)

N^nd.1

(Micchelli and Perrimon, 2006)

N^nd1

(Tremmel et al., 2013, Zhang et al., 2013)

N^nd

(Jack and DeLotto, 1992)

(Lloyd, 2000, Cornell et al., 1999, de Celis et al., 1993, Gorman and Girton, 1992, Rabinow and Birchler, 1990, Xu and Artavanis-Tsakonas, 1990, Ramos et al., 1989, Grimwade et al., 1985, Shellenbarger and Mohler, 1975, Welshons, 1974, Welshons, 1965)

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