FlyBase Allele Report: Dmel\Ada2b[1]

General Information

Symbol

Dmel\Ada2b¹

Species

D. melanogaster

Name

FlyBase ID

FBal0176420

Feature type

allele

Associated gene

Dmel\Ada2b

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Qi et al., 2004)

Progenitor genotype

P{EP}EP3412

(Qi et al., 2004)

Cytology

Description

Imprecise excision of the P{EP} element, resulting in a 1077bp deletion that encompasses the Ada2b transcription start site and entire first exon (including the translation start codon).

(Qi et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:8,239,519..8,240,595 [-]

Comment:

Imprecise excision of the P{EP} element, resulting in a 1077bp deletion that encompasses the Ada2b transcription start site and entire first exon.

(Qi et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration | oogenesis | somatic clone

(Badmos et al., 2021)

abnormal neuroanatomy

(Weake et al., 2008)

abnormal neurophysiology | larval stage

(Wang et al., 2020)

female sterile | germline clone | recessive

(Qi et al., 2004)

fertile (with Ada2b^d842), with Ada2b^PA

(Torres-Zelada et al., 2019)

fertile (with Ada2b^d842), with Ada2b^PA, Ada2b^PB

(Torres-Zelada et al., 2019)

lethal (with Ada2b^d842)

(Torres-Zelada et al., 2019)

lethal - all die before end of pupal stage | recessive

(Qi et al., 2004)

some die during pupal stage | recessive

(Qi et al., 2004)

Phenotype Manifest In

axon & photoreceptor cell R2

(Weake et al., 2008)

axon & photoreceptor cell R3

(Weake et al., 2008)

axon & photoreceptor cell R4

(Weake et al., 2008)

axon & photoreceptor cell R5

(Weake et al., 2008)

border follicle cell | somatic clone

(Badmos et al., 2021)

embryonic/larval neuromuscular junction | larval stage

(Wang et al., 2020)

glial cell

(Weake et al., 2008)

Detailed Description

Statement

Reference

Follicle border cell clusters either fully clonal or mosaic for Ada2b¹/Ada2b¹ show severely delayed migration.

(Badmos et al., 2021)

Ada2b¹ mosaic adults in which the eyes are homozygous for Sf3b5^EY12579, while the rest of the body is heterozygous (generated by the EGUF method) show normal eye size compared to controls.

(Stegeman et al., 2016)

In Ada2b¹ larvae, many R2-R5 axons fail to terminate in the lamina and instead project into the medulla. A reduced number of glial cells are present along the lamina compared to wild type and slight increases in the number of glial cells are present at the margins of the lamina regions.

(Weake et al., 2008)

Homozygotes die during early pupal stages, mostly before head eversion occurs, without any other gross morphological abnormalities. No eggs are obtained from females containing homozygous germline clones.

(Qi et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Ada2b¹ has abnormal neurophysiology | larval stage phenotype, non-suppressible by Mp^{ES.UAS.Tag:SS(wg)}/Scer\GAL4^egr-GAL4

(Wang et al., 2020)

Other

Statement

Reference

Ada2b¹, GluRIIA^SP16 has abnormal neurophysiology | larval stage phenotype

(Wang et al., 2020)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Ada2b¹ has embryonic/larval neuromuscular junction | larval stage phenotype, non-suppressible by Mp^{ES.UAS.Tag:SS(wg)}/Scer\GAL4^egr-GAL4

(Wang et al., 2020)

Enhancer of

Statement

Reference

Ada2b[+]/Ada2b¹ is an enhancer of wing margin phenotype of mam^g2.1

(Gause et al., 2006)

NOT Enhancer of

Statement

Reference

Ada2b[+]/Ada2b¹ is a non-enhancer of wing blade phenotype of N^nd-1

(Gause et al., 2006)

NOT Suppressor of

Statement

Reference

Ada2b[+]/Ada2b¹ is a non-suppressor of wing vein L4 phenotype of N^Ax-E2

(Gause et al., 2006)

Other

Statement

Reference

Ada2b¹, GluRIIA^SP16 has embryonic/larval neuromuscular junction | larval stage phenotype

(Wang et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for Ada2b¹ increases the number of wing margin nicks seen in mam^g2.1 heterozygotes.

(Gause et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Ada2b¹ is rescued by Ada2b^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^egr-GAL4

(Wang et al., 2020)

Ada2b¹/Ada2b^d842 is rescued by Ada2b^PA/Ada2b^PB

(Torres-Zelada et al., 2019)

Ada2b¹ is rescued by Ada2b^+t6.1

(Qi et al., 2004)

Partially rescued by

Ada2b¹/Ada2b^d842 is partially rescued by Ada2b^PA

(Torres-Zelada et al., 2019)

Not rescued by

Ada2b¹/Ada2b^d842 is not rescued by Ada2b^PB

(Torres-Zelada et al., 2019)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Ada2b¹

(Torres-Zelada et al., 2022, Li et al., 2017, Gause et al., 2006)

ada2b¹

(Badmos et al., 2021, Soffers et al., 2021, Wang et al., 2020, Torres-Zelada et al., 2019, Stegeman et al., 2016, Weake et al., 2011, Weake et al., 2008)

dAda2b¹

(Qi et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

Open Close