FB2024_03 , released June 25, 2024
Allele: Dmel\osk2
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General Information
Symbol
Dmel\osk2
Species
D. melanogaster
Name
FlyBase ID
FBal0013304
Feature type
allele
Associated gene
Dmel\osk
Associated Insertion(s)
Carried in Construct
Also Known As
osk84, osk084
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C1336T.

(Kim-Ha et al., 1991)

Amino acid replacement: R254term.

(Kim-Ha et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:8,936,153..8,936,153 [+]
Nucleotide change:

C8936153T

Reported nucleotide change:

C1336T

Amino acid change:

R254term | osk-PA; R116term | osk-PC

Reported amino acid change:

R254term

(Kim-Ha et al., 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dvir\oskvirosk provides poterior body patterning to osk2 and osk6 embryos, but in some instances the activity has spread towards the anterior of the embryo.

      (Webster et al., 1994)

      Lack posterior body pattern elements and germ cells.

      (Kim-Ha et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      btz1, osk2 has abdominal segment phenotype, enhanceable by CG748319

      (Palacios et al., 2004)
      Other
      Statement
      Reference

      btz1, osk2 has abdominal segment phenotype

      (Palacios et al., 2004)

      btz1, osk2/osk[+] has abdominal segment phenotype

      (Palacios et al., 2004)

      btz[+]/btz1, osk2 has abdominal segment phenotype

      (Palacios et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos produced by btz1 females with one copy of osk2 show a partial loss of abdominal segments. This phenotype is enhanced by the presence of eIF4AIII19.

      (Palacios et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      osk187

      (Jenny et al., 2006)

      oskA87

      (Jenny et al., 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Abnormal localization of osk mRNA.

      (Kim-Ha et al., 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (28)