FlyBase Allele Report: Dmel\ovo[D1rv22]

General Information

Symbol

Dmel\ovo^D1rv22

Species

D. melanogaster

Name

FlyBase ID

FBal0013399

Feature type

allele

Associated gene

Dmel\ovo

Associated Insertion(s)

gypsy{}ovo^D1rv22

Carried in Construct

Also Known As

lzl^G, ovo^lzl

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Oliver et al., 1993)

loss of function allele

(Staab and Steinmann-Zwicky, 1996, Garfinkel et al., 1992)

Mutagen

spontaneous

(Garfinkel et al., 1992)

gypsy element activity

(Dej et al., 1998)

Progenitor genotype

ovo^D1

(Dej et al., 1998, Garfinkel et al., 1992, Oliver et al., 1987)

Associated Insertion(s)

gypsy{}ovo^D1rv22

Cytology

Description

Insertion of a gypsy element.

(Dej et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | heat sensitive

(Perrimon and Gans, 1983)

female sterile | recessive

(Oliver and Pauli, 1998, Oliver et al., 1990)

visible | cold sensitive

(Garfinkel et al., 1992, Oliver et al., 1990)

Phenotype Manifest In

Detailed Description

Statement

Reference

The ovaries of ovo^D1rv22 females are primarily agametic.

(Waterbury et al., 2000)

In homozygous mutant germaria, very few egg chambers are found. Those rare egg chambers that are found are small and have no nurse cells.

(Hinson et al., 1999)

Ovaries of homozygous females contain germline chambers in less than 20% of cases. Ovaries of ovo^D1rv23/ovo^D1rv22 females contain germline chambers in less than 20% of cases.

(Oliver and Pauli, 1998)

Homozygous female embryos contain the normal number of germ cells. By the end of the third larval instar stage many homozygous female larvae have a reduced number or no germ cells.

(Staab and Steinmann-Zwicky, 1996)

XX females have agametic ovaries. ovo^D1rv22/Y pseudofemales (carrying tra^Hsp83.PS) have ovaries that contain large numbers of tumorous egg cysts.

(Nagoshi et al., 1995)

Agametic adult ovaries. Many larval ovaries of the agametic heteroallelic combination ovo^D1rv23/ovo^D1rv22 have near wild type morphology.

(Rodesch et al., 1995)

The germ cells of XO ovo[-] males have the crystals characteristic of XO males and are fully populated with male germ cells of all stages.

(Oliver et al., 1994)

Cold sensitive eye phenotype. ovo^-, svb⁺ phenotype.

(Garfinkel et al., 1992)

Phenotypic category: lzl^-.

(Lindsley and Zimm, 1992)

Germ cell death occurs during early embryogenesis in homozygotes. Adults have rough or glazed eyes (this phenotype is cold-sensitive).

(Oliver et al., 1990)

Gene activity is not detectable. Viable. Male germ line is fertile, female germ line has no vitellogenic egg chambers.

(Oliver et al., 1987)

At the non-permissive temperature homozygous females lay no eggs.

(Perrimon and Gans, 1983)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

ovo^D1rv22 has ovary phenotype, suppressible by mle¹

(Oliver and Pauli, 1998)

ovo^D1rv22 has ovary phenotype, suppressible by mle⁹

(Oliver and Pauli, 1998)

ovo^D1rv22 has ovary phenotype, suppressible by mle¹⁴/mle¹

(Oliver and Pauli, 1998)

ovo^D1rv22/ovo^D1rv23 has germline cell phenotype, suppressible by mle⁵/mle¹

(Oliver et al., 1993)

NOT suppressed by

Statement

Reference

ovo^D1rv22 has ovary phenotype, non-suppressible by Sxl^M4

(Oliver and Pauli, 1998)

ovo^D1rv22 has ovary phenotype, non-suppressible by Sxl^M1

(Oliver and Pauli, 1998)

ovo^D1rv22 has ovary phenotype, non-suppressible by msl-2¹³⁸

(Oliver and Pauli, 1998)

ovo^D1rv22 has ovary phenotype, non-suppressible by msl-2¹³⁸/msl-2¹

(Oliver and Pauli, 1998)

Other

Statement

Reference

Sxl^M1, mle¹, ovo^D1rv22 has ovary phenotype

(Oliver and Pauli, 1998)

mle¹⁴/mle⁹, ovo^D1rv22 has ovary phenotype

(Oliver and Pauli, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

ovo^D1rv22 have no adverse effect on the development of the germline in XY tra^F.Hsp83 pseudofemales; the pseudo-ovaries are filled with a multitude of undifferentiated germ cells.

(Waterbury et al., 2000)

The ovary phenotype of homozygous ovo^D1rv22 females is partially suppressed if they are also carrying mle¹/mle¹, mle⁹/mle⁹ or mle¹/mle¹⁴. The ovary phenotype is of ovo^D1rv23/ovo^D1rv22 females partially suppressed if they are also carrying mle¹/mle¹. The phenotype is not affected if the females are also carrying Sxl^M4 or Sxl^M1. The phenotype is not affected if the females are also carrying msl-2¹³⁸/msl-2¹³⁸ or msl-2¹³⁸/msl-2¹. ovo^D1rv23/ovo^D1rv22; mle⁹/mle¹⁴ ovaries are phenotypically mosaic, containing germ cells of both male and female morphology. The mosaicism can be at the level of whole ovaries or ovarioles. ovo^D1rv22/ovo^D1rv22; mle¹/mle¹ ovaries most often contain germ cells of male morphology rather than female morphology. This phenotype is partially suppressed by Sxl^M1; ovaries more often contain germ cells of female morphology rather than male morphology.

(Oliver and Pauli, 1998)

ovo[-],tra^hs.PM XY ovaries have abundant germ cells.

(Oliver et al., 1994)

The survival of 2X ovo^D1rv23/ovo^D1rv22 germline cells is enhanced in an mle¹/mle⁵ background. Surviving cells usually form small ovarian tumours. Sxl^M1 partially rescues the morphology of the otu mutant ovarian tumour cells.

(Oliver et al., 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

ovo^e8F

(Oliver and Pauli, 1998)

ovo^M2

(Oliver and Pauli, 1998)

ovo^M1

(Oliver and Pauli, 1998)

ovo^D1rv23

(Oliver and Pauli, 1998)

ovo^e7E

(Oliver and Pauli, 1998)

ovo^e8K

(Oliver and Pauli, 1998)

Partially rescued by

ovo^D1rv22 is partially rescued by ovo^OW10.0

(Garfinkel et al., 1992)

Comments

The eye phenotype is partially suppressed by two (but not one) copies of ovo^OW10.0.

(Garfinkel et al., 1992)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

38444

y¹ w^* ovo^D1rv22/FM3

Notes on Origin

Discoverer

Revertant.

(Dej et al., 1998)

Comments

Severe ovo allele.

(Rodesch et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

lzl^G

(Nagoshi et al., 1995, Rodesch et al., 1995, Oliver et al., 1994, Oliver et al., 1993, Oliver et al., 1990, Oliver et al., 1987, Perrimon and Gans, 1983)

ovo^D1rv22

ovo^lzl

(Hinson et al., 1999, Dej et al., 1998, Staab and Steinmann-Zwicky, 1996, Garfinkel et al., 1992)

ovo^lzlG

(Waterbury et al., 2000)

ovoD1^rv22

(Sahut-Barnola and Pauli, 1999)

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

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