FB2024_03 , released June 25, 2024
Allele: Dmel\pal1
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General Information
Symbol
Dmel\pal1
Species
D. melanogaster
Name
FlyBase ID
FBal0013471
Feature type
allele
Associated gene
Dmel\pal
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q92term.

(Dubruille et al., 2023)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:9,624,950..9,624,950 [-]
Nucleotide change:

C9624950T

Amino acid change:

Q92term | pal-PA

Reported amino acid change:

Q92term

Comment:

Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Dubruille et al., 2023)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pal1 causes chromosome elimination, elimination of ring and rod chromosomes and mitotic exchanges in the pronucleus.

      (Omel'yanchuk, 1996)

      Causes the loss of paternally-derived chromosomes among the progeny of homozygous males. Different chromosomes are lost at different rates. Loss may occur in the zygote and affect the whole body or during early mitotic divisions giving rise to mosaicism.

      (Lindsley and Zimm, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      pal1/Df(2L)Exel6024 has male pronucleus | paternal effect phenotype, non-enhanceable by Hira185b

      (Dubruille et al., 2023)
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      pal1/Df(2L)Exel6024 has male pronucleus | paternal effect phenotype, non-suppressible by Hira185b

      (Dubruille et al., 2023)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      pal1/Df(2L)Exel6024 is rescued by pal+t8

      (Dubruille et al., 2023)
      Partially rescued by

      pal1/Df(2L)ED690 is partially rescued by pal+t8

      (Dubruille et al., 2023)

      pal1/Df(2L)ED690 is partially rescued by palTag:V5

      (Dubruille et al., 2023)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (4)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mosaics with large patches can be generated by early chromosome loss in the progeny of pal1 males and allows the construction of fate maps of the blastoderm.

      (Lindsley and Zimm, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      pal1
      (Dubruille et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)