FlyBase Allele Report: Dmel\Sb[70]

General Information

Symbol

Dmel\Sb⁷⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0015147

Feature type

allele

Associated gene

Dmel\Sb

Associated Insertion(s)

blood{}Sb⁷⁰

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Gotwals and Fristrom, 1991)

Progenitor genotype

Associated Insertion(s)

blood{}Sb⁷⁰

Cytology

Description

Insertion of a blood element in the 3' region of Sb, which results in a truncated transcript of approximately 2.8kb.

(Hammonds and Fristrom, 2006)

May have an insertion between -55.5 and -57kb.

(Appel et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Sb^63b)

(Bayer et al., 2003)

lethal | recessive

(Bayer et al., 2003)

visible | dominant

(Chen et al., 2004, Gotwals and Fristrom, 1991)

Phenotype Manifest In

leg

(Chen et al., 2004)

Detailed Description

Statement

Reference

7% of heterozygotes have a malformed leg phenotype.

(Chen et al., 2004)

Sb¹, T(2;3)Sb^V, and Sb^Spi are much less severe in phenotype, both in bristle length and frequency and severity of malformation of appendages, than Sb^63b and Sb⁷⁰.

(Appel, 1995)

zip interacts to some degree with all Sb dominant mutations.

(Gotwals and Fristrom, 1991)

strong allele homozygous viable

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Sb⁷⁰ has visible | dominant phenotype, enhanceable by LIMK1^D522A.UAS/Scer\GAL4^hs.PB

(Chen et al., 2004)

Sb⁷⁰ has visible | dominant phenotype, enhanceable by Rho1^72O/Rho1[+]

(Chen et al., 2004)

Sb⁷⁰ has visible | dominant phenotype, enhanceable by rok[+]/Rok¹

(Chen et al., 2004)

Sb⁷⁰ has visible | dominant phenotype, enhanceable by Rho1[+]/Rho1^k02107b

(Chen et al., 2004)

Sb⁷⁰ has visible | dominant phenotype, enhanceable by zip[+]/zip^Ebr

(Chen et al., 2004)

NOT Enhanced by

Statement

Reference

Sb⁷⁰ has visible | dominant phenotype, non-enhanceable by Rac1^J11/Rac1[+]

(Chen et al., 2004)

Sb⁷⁰ has visible | dominant phenotype, non-enhanceable by Rac2³¹⁴/Rac2[+]

(Chen et al., 2004)

Sb⁷⁰ has visible | dominant phenotype, non-enhanceable by Cdc42[+]/Cdc42³

(Chen et al., 2004)

Sb⁷⁰ has visible | dominant phenotype, non-enhanceable by Cdc42[+]/Cdc42⁴

(Chen et al., 2004)

Enhancer of

Statement

Reference

Sb[+]/Sb⁷⁰ is an enhancer of visible phenotype of LIMK1^D522A.UAS, Scer\GAL4^hs.PB

(Chen et al., 2004)

Other

Statement

Reference

E(zip)31-6^31-6, Sb[+]/Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb[+]/Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹, Sb[+]/Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

RhoGEF2^1.1, Sb[+]/Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

Sb⁷⁰, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^72O/Rho1[+], Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

Df(2R)Jp1/+, Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^72F, Sb[+]/Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

Rho1^72F/Rho1[+], Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹/RhoGEF2[+], Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^1.1/RhoGEF2[+], Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

rok[+]/Rok², Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

E(zip)12-5[+]/E(zip)12-5^12-5, Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

E(zip)18-5[+]/E(zip)18-5^18-5, Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6/E(zip)31-6[+], Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

Rho1^12-6/Rho1[+], Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

Sb⁷⁰, zip^33-1/zip[+] has visible phenotype

(Bayer et al., 2003)

Rho1^72O, Sb[+]/Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

Rok², Sb[+]/Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

Sb[+]/Sb⁷⁰, zip^33-1 has visible | dominant phenotype

(Bayer et al., 2003)

Sb[+]/Sb⁷⁰, zip^Ebr has visible phenotype

(Bayer et al., 2003)

Rok¹, Sb[+]/Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^E3.10, Sb[+]/Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

Rok¹, Sb[+]/Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb[+]/Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb[+]/Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

Rho1^12-6, Sb[+]/Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Sb[+]/Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Sb[+]/Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Sb⁷⁰ has leg phenotype, enhanceable by LIMK1^D522A.UAS/Scer\GAL4^hs.PB

(Chen et al., 2004)

Sb⁷⁰ has leg phenotype, enhanceable by Rho1^72O/Rho1[+]

(Chen et al., 2004)

Sb⁷⁰ has leg phenotype, enhanceable by rok[+]/Rok¹

(Chen et al., 2004)

Sb⁷⁰ has leg phenotype, enhanceable by Rho1[+]/Rho1^k02107b

(Chen et al., 2004)

Sb⁷⁰ has leg phenotype, enhanceable by zip[+]/zip^Ebr

(Chen et al., 2004)

NOT Enhanced by

Statement

Reference

Sb⁷⁰ has leg phenotype, non-enhanceable by Rac1^J11/Rac1[+]

(Chen et al., 2004)

Sb⁷⁰ has leg phenotype, non-enhanceable by Rac2³¹⁴/Rac2[+]

(Chen et al., 2004)

Sb⁷⁰ has leg phenotype, non-enhanceable by Cdc42[+]/Cdc42³

(Chen et al., 2004)

Sb⁷⁰ has leg phenotype, non-enhanceable by Cdc42[+]/Cdc42⁴

(Chen et al., 2004)

Enhancer of

Statement

Reference

Sb[+]/Sb⁷⁰ is an enhancer of leg phenotype of LIMK1^D522A.UAS, Scer\GAL4^hs.PB

(Chen et al., 2004)

Other

Statement

Reference

E(zip)31-6^31-6, Sb[+]/Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

RhoGEF2^1.1, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6, Sb[+]/Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Sb⁷⁰, zip[+]/zip^Ebr has wing phenotype

(Bayer et al., 2003)

Rho1^72O/Rho1[+], Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rok¹, Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Df(2R)Jp1/+, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rho1^72F/Rho1[+], Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹/RhoGEF2[+], Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

RhoGEF2^1.1/RhoGEF2[+], Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rho1^72F, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

rok[+]/Rok², Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6, Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rho1^12-6, Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

Rho1^72O, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rho1^12-6, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Sb⁷⁰, zip^33-1 has leg phenotype

(Bayer et al., 2003)

Rok², Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Sb[+]/Sb⁷⁰, zip^33-1 has leg phenotype

(Bayer et al., 2003)

Sb⁷⁰, zip^Ebr has wing phenotype

(Bayer et al., 2003)

Rok¹, Sb[+]/Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

Rok¹, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb[+]/Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb[+]/Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rho1^12-6, Sb[+]/Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

Rho1^12-6, Sb[+]/Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10, Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Sb[+]/Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Sb[+]/Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Sb[+]/Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Sb[+]/Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of the malformed leg phenotype seen in Sb⁷⁰/+ heterozygotes (7%) is increased if the flies are also heterozygous for Rho1^72O (56%), Rho1^k02107b (95%), rok¹ (94%) or zip^Ebr (96%). The frequency of the malformed leg phenotype seen in Sb⁷⁰/+ heterozygotes (7%) is not increased if the flies are also heterozygous for Rac1^J11/+ (2%), Rac2³¹⁴/+ (8%), Cdc42³/+ (7%) or Cdc42⁴/+ (8%). Expression of LIMK1^{D522A.Scer\UAS} under the control of Scer\GAL4^hs.PB enhances the frequency of the malformed leg phenotype seen in Sb⁷⁰/+ heterozygotes from 7% to 84%.

(Chen et al., 2004)

Sb⁷⁰ shows a strong interaction (at least 50% of double heterozygotes have at least one malformed leg) with the following mutations: Rho1^12-6, Rho1^J3.8, Rho1^E3.10, Rho1^72F, Rho1^72O, Df(2R)Jp8, rok¹, rok². Sb⁷⁰ shows a moderate interaction (25-49% of double heterozygotes have at least one malformed leg) with the following mutations: RhoGEF2^11-3, Df(2R)Jp1, E(zip)18-5^18-5, E(zip)31-6^31-6, zip^33-1 and E(zip)12-5^12-5. Sb⁷⁰ shows a weak interaction (5-24% of double heterozygotes have at least one malformed leg) with the following mutations: RhoGEF2^1.1, RhoGEF2⁰⁴²⁹¹. Sb⁷⁰ shows no interaction with Pkn³ or Pkn⁰⁶⁷³⁶ (assayed in terms of a malformed leg phenotype). Sb⁷⁰ shows a strong interaction (at least 50% of double heterozygotes have at least one malformed wing) with the following mutations: Rho1^E3.10, Rho1^J3.8 and zip^Ebr. Sb⁷⁰ shows a strong interaction (at least 50% of double heterozygotes have at least one malformed wing) with the following mutations: Rho1^12-6. Sb⁷⁰ shows a moderate interaction (25-49% of double heterozygotes have at least one malformed wing) with the following mutations: rok¹ and RhoGEF2^11-3. Sb⁷⁰ shows a weak interaction (5-24% of double heterozygotes have at least one malformed wing) with the following mutations: E(zip)12-5^12-5, E(zip)18-5^18-5 and E(zip)31-6^31-6.

(Bayer et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Sb⁷⁰

(Hammonds and Fristrom, 2006)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

Open Close