FB2024_02 , released April 23, 2024
Allele: Dmel\sev1
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General Information
Symbol
Dmel\sev1
Species
D. melanogaster
Name
FlyBase ID
FBal0015445
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sevLY3
Key Links
Nature of the Allele
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The climbing initiation behaviour and gap-crossing success of sev1 flies is not different from wild-type flies.

R8 cells occupy the vacant R7 position. Several facets are missing R8 and R7 cells.

Ommatidia of homozygotes have no central rhabdomeres. Ommatidia of double mutants with aoppok-1 contain a variable number of R7-like cells.

Absence of R7, insensitivity to UV-light.

Inner rhabdomere seven is missing.

Flies lack R7 receptor cells in every ommatidium. Flies show positive phototaxis (similar to wild-type) in response to extremely dim light stimuli.

negative phototaxis with Ppb/+

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

sev1 has abnormal visual behavior phenotype, suppressible by Ppb[+]/Ppb1

sev1 has abnormal phototaxis phenotype, suppressible by Ppb[+]/Ppb1

Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

sev1, Rh52, Rh61 triple mutant flies do not have R7 cells and do not express function R8 opsins, therefore colour vision should be completely abolished. However, the blue/green intensity-response curve for these flies appears indistinguishable from wild-type.

Double mutants of sl1 or sl2 with either sev1 or sev14 show a mutant phenotype intermediate to that of either single mutant: 35-49% of ommatidia have one R7 cell, 6-12% contain two R7 cells and the rest have no R7 cells.

SosJC2 does not suppress the mutant phenotype, R7 cells are absent from ommatidia.

sev1 mutants - i.e. sev1; Ppb1/+ flies, like wild-type flies, prefer UV over green light, while sev1;+/+ flies prefer green over UV. When tested in a T-maze for preference between darkness and green light (550 nm), both wild type and sev1 flies show positive phototaxis, while sev1;Ppb1/+ and sev1;Ppb1/Ppb1 flies show negative phototaxis. Similarly, tests in a countercurrent apparatus for movement toward and movement away from white light indicate marked preference of wild-type flies for light and of sev1;Ppb1/+ flies for darkness. Both the positive phototactic response of sev1 and the negative phototactic response of sev1;Ppb1/+ flies increase with age, reaching a maximum at 4-6 days. The interaction between Ppb and sev is allele-specific, as is indicated in the sev allele entries. Photoreceptor cell R7, missing in all of the sev alleles, was not restored in any mutant combination of Ppb and sev.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Harris.

Comments
Comments

Normal orientation effects in the fixation Y-maze.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (22)