FlyBase Allele Report: Dmel\sim[1]

General Information

Symbol

Dmel\sim¹

Species

D. melanogaster

Name

FlyBase ID

FBal0015656

Feature type

allele

Associated gene

Dmel\sim

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Lindsley and Zimm, 1992, Thomas et al., 1988)

Mutagen

X ray

(Hilliker et al., 1981)

Progenitor genotype

Cytology

Description

5bp deletion (of nucleotides GACAC) in exon 10, resulting in a frameshift at amino acid residue D334 and a stop codon at residue 441.

(Freer et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:13,076,476..13,076,480 [+]

Comment:

5 bp deletion of nucleotides GACAC) in exon 10, resulting in a frameshift.

(Freer et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Lindsley and Zimm, 1992, Thomas et al., 1988)

lethal

(Hilliker et al., 1981)

lethal - all die during embryonic stage

(Lindsley and Zimm, 1992, Thomas et al., 1988)

some die during embryonic stage

(Lindsley and Zimm, 1992, Thomas et al., 1988)

Phenotype Manifest In

Detailed Description

Statement

Reference

Denticle bands of all segments narrow. Both head skeleton ventral arms and anal plates fused. In the ventral nervous system, transverse commissures lacking entirely. Midline neurons and supportive mesectodermal cells missing. Germline viable with no maternal component. Deficiency test indicates that sim¹ is amorphic.

(Lindsley and Zimm, 1992)

CNS defect: specific alterations in the pattern of precursors that give rise to the 2 MP1 progeny, ventral unpaired median neurons and the specialized ectodermal cells, the midline ectodermal cells (MEC).

(Thomas et al., 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

sim¹ is a non-suppressor of eye phenotype of rho^hs.sev

(Freeman, 1994)

Additional Comments

Genetic Interactions

Statement

Reference

sim¹/ast^K6 double heterozygotes do not have a visible phenotype.

(Kotarski et al., 1998)

Mutation has no effect on rho^hs.sev rough eye phenotype.

(Freeman, 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

101938

cn¹ bw¹ speck¹ ; kar² sim¹ / MRS

Notes on Origin

Discoverer

Schalet.

(Lindsley and Zimm, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

l(3)S8

(Thomas et al., 1988)

sim¹

(Freer et al., 2011, Freer et al., 2011)

sim^S8

(Freeman, 1994)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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