FlyBase Allele Report: Dmel\Su(var)205[1]

General Information

Symbol

Dmel\Su(var)205¹

Species

D. melanogaster

Name

FlyBase ID

FBal0016503

Feature type

allele

Associated gene

Dmel\Su(var)205

Associated Insertion(s)

Carried in Construct

Also Known As

Su(var)2-5⁰¹, Su(var)205

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Sinclair et al., 1983)

Progenitor genotype

Cytology

Description

Point mutation in the splicing site leading to deletion of the domain important for its localisation in the nucleus and association with heterochromatin in salivary glands.

(Kellum and Alberts, 1995)

Nucleotide substitution: G?A. Mutation at the first nucleotide position of intron 4. Mutation leads to exon skipping.

(Eissenberg et al., 1990)

Nucleotide substitution: G?A. Mutation at the first nucleotide of the last intron.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:8,210,352..8,210,352 [-]

Nucleotide change:

G8210352A

Reported nucleotide change:

G?A

Comment:

Mutation in the first nucleotide of intron 4. The mutation leads to exon skipping.

(Eissenberg et al., 1990)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Sinclair et al., 1983)

lethal - all die during embryonic stage | maternal effect | recessive

(Kellum and Alberts, 1995)

some die during embryonic stage | recessive | maternal effect | recessive

(Kellum and Alberts, 1995)

suppressor of variegation | dominant, with In(1)w^m4

(Sinclair et al., 1983)

Phenotype Manifest In

neuroblast & larval brain

(Fanti et al., 1998)

Detailed Description

Statement

Reference

Neuroblasts in the brain of Su(var)205¹/Su(var)205⁵ or Su(var)205⁴/Su(var)205¹ larvae show a high frequency of abnormal metaphase configurations, including telomere-telomere fusions.

(Fanti et al., 1998)

Homozygous embryos are found to be mostly devoid of intact nuclei. Any remaining nuclei have defects in chromosome segregation and abnormal morphology (chromatin bridges, chromosome lagging during anaphase and under- or over-condensed nuclei). Mitotic synchrony is lost in a high proportion of embryos and defective nuclei are seen beneath the normal plane of nuclei, they appear to be falling into the interior of the embryo.

(Kellum and Alberts, 1995)

Dominant suppression of heterochromatic position effect.

(Eissenberg et al., 1990)

Dominant suppressor of position effect variegation at the w locus caused by In(1)w^m4.

(Sinclair et al., 1983)

homozygous lethal triplo-enhancer homozygous lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Su(var)205¹ is an enhancer of visible | dominant phenotype of N^55e11, RpL15[+]/RpL15⁷²

(Schulze et al., 2005)

Su(var)205[+], E(Pc)[+], Su(var)205¹, E(Pc)^unspecified is an enhancer of abnormal eye color phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)208[+], Su(var)208^unspecified, Su(var)205[+], Su(var)205¹ is an enhancer of abnormal eye color phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)205¹/E(Pc)^unspecified is an enhancer of abnormal eye color | recessive phenotype of lt¹¹

(Clegg et al., 1998)

Su(var)208^unspecified/Su(var)205¹ is an enhancer of abnormal eye color | recessive phenotype of lt¹¹

(Clegg et al., 1998)

Other

Statement

Reference

Su(var)2-1^v9, Su(var)205¹, lt¹/lt¹¹ has partially lethal phenotype

(Clegg et al., 1998)

Su(var)205¹, Su(var)208^unspecified, lt¹/lt¹¹ has partially lethal phenotype

(Clegg et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Su(var)205¹ is an enhancer of wing margin | posterior | female phenotype of In(3L)C90/+, RpL15³

(Schulze et al., 2005)

Su(var)205¹ is an enhancer of wing margin phenotype of N^55e11, RpL15[+]/RpL15⁷²

(Schulze et al., 2005)

Su(var)205¹ is an enhancer of wing margin | posterior phenotype of In(3L)C90/+, RpL15⁷²

(Schulze et al., 2005)

Su(var)205[+], E(Pc)[+], Su(var)205¹, E(Pc)^unspecified is an enhancer of pigment cell phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)208[+], Su(var)208^unspecified, Su(var)205[+], Su(var)205¹ is an enhancer of pigment cell phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)205¹/E(Pc)^unspecified is an enhancer of pigment cell phenotype of lt¹¹

(Clegg et al., 1998)

Su(var)208^unspecified/Su(var)205¹ is an enhancer of pigment cell phenotype of lt¹¹

(Clegg et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

13% of RpL15⁷²/In(3L)C90 males and 60% of RpL15⁷²/In(3L)C90 females have a mutant posterior wing margin phenotype. The penetrance of this phenotype is increased to 100% if the flies are also carrying Su(var)205¹/+. 13% of RpL15³/In(3L)C90 females have a mutant posterior wing margin phenotype. The penetrance of this phenotype is increased to 81% if the females are also carrying Su(var)205¹/+. RpL15⁷²/+ slightly enhances the weak wing margin phenotype of N^55e11/+. The effect of RpL15⁷² on N^55e11 is further enhanced if the flies also carry Su(var)205¹.

(Schulze et al., 2005)

Eye pigmentation in lt¹¹/lt¹ flies is reduced if the flies are also carrying E(Pc)^unspecified/Su(var)205¹ or Su(var)208^unspecified/Su(var)205¹. lt¹¹/lt¹; Su(var)2-1^v9/Su(var)205¹ flies have reduced viability. Viability is partially restored in XO males. lt¹¹/lt¹; Su(var)208^unspecified/Su(var)205¹ flies have reduced viability. Viability is restored in XO males.

(Clegg et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Su(var)205¹ is rescued by Su(var)205^hs.PE

(Kellum and Alberts, 1995)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

The presence of Su(var)205¹ suppresses position effect variegation (PEV) of lines with insertions in centromeric regions or in the fourth chromosome. Insertions near the telomeres 2L, 2R or 3R show no suppression.

(Wallrath and Elgin, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

205

(Clegg et al., 1998)

Su(var)2-5

Su(var)2-501

(Netter et al., 1998)

Su(var)2-5⁰¹

(Vasanthi et al., 2013, Kalmykova et al., 2005, Schulze et al., 2005, Westphal and Reuter, 2002, Gvozdev et al., 2000, Naumova et al., 2000, Ronsseray et al., 1996)

Su(var)205

(Fanti et al., 1998, Sinclair et al., 1983)

Su(var)205⁰¹

(Wallrath and Elgin, 1995)

Su(var)205¹

(Haigh and Lloyd, 2007)

Su-var(2)501

(Fauvarque and Dura, 1993)

Suvar(2)5¹

(Sigrist and Pirrotta, 1997)

Suvar2-5

(Kellum and Alberts, 1995)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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