FlyBase Allele Report: Dmel\Su(var)208[unspecified]

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Allele: Dmel\Su(var)208^unspecified

General Information

Symbol

Dmel\Su(var)208^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0049170

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Hearn et al., 1991)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

(Doheny et al., 2008)

suppressor of variegation, with Byron

(Sass and Henikoff, 1998)

suppressor of variegation, with In(1)w^m4

(Sass and Henikoff, 1998)

suppressor of variegation, with P{wA^R}41A

(Sass and Henikoff, 1998)

suppressor of variegation | dominant, with In(1)w^m4

(Doheny et al., 2008)

(Doheny et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

One copy of Su(var)208^unspecified strongly suppresses position effect variegation (PEV) at the w locus caused by In(1)w^m4.

The copy of Su(var)208^unspecified is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

(Doheny et al., 2008)

Suppresses the position effect variegation at the w locus caused by In(1)w^m4 and suppresses the position effect variegation at the bw locus caused by Byron. Also suppresses the position effect variegation of w seen in the P{wA^R}41A insertion.

(Sass and Henikoff, 1998)

Strong enhancer of variegation at the lt locus. Also enhances variegation at the l(2)40Fa, l(2)40Fc, cta and l(2)40Ff loci.

(Hearn et al., 1991)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Su(var)208[+], Su(var)208^unspecified, E(Pc)[+], E(Pc)^unspecified is an enhancer of abnormal eye color phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)208^unspecified/Su(var)205¹ is an enhancer of abnormal eye color | recessive phenotype of lt¹¹

(Clegg et al., 1998)

Su(var)2-1¹/Su(var)208^unspecified is an enhancer of abnormal eye color | recessive phenotype of lt¹¹

(Clegg et al., 1998)

Su(var)208^unspecified/Su(var)2-1^v9 is an enhancer of abnormal eye color | recessive phenotype of lt¹¹

(Clegg et al., 1998)

Su(var)208^unspecified/Su(var)2-1^v9 is an enhancer of abnormal eye color phenotype of lt¹¹

(Clegg et al., 1998)

Su(var)208[+], Su(var)208^unspecified, Su(var)205[+], Su(var)205¹ is an enhancer of abnormal eye color phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)2-1[+], Su(var)208[+], Su(var)2-1¹, Su(var)208^unspecified is an enhancer of abnormal eye color phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)2-1[+], Su(var)208[+], Su(var)208^unspecified, Su(var)2-1^v9 is an enhancer of abnormal eye color phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)208^unspecified/E(Pc)^unspecified is an enhancer of abnormal eye color | recessive phenotype of lt¹¹

(Clegg et al., 1998)

Su(var)208^unspecified/E(Pc)^unspecified is an enhancer of abnormal eye color phenotype of lt¹¹

(Clegg et al., 1998)

Other

Statement

Reference

Su(var)205^unspecified, Su(var)208^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1¹, Su(var)208^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁴, Su(var)208^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)208^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁶, Su(var)208^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

E(Pc)^unspecified, Su(var)208^unspecified, lt¹¹ has abnormal eye color phenotype

(Clegg et al., 1998)

Su(var)2-1^v9, Su(var)208^unspecified, lt¹¹ has abnormal eye color phenotype

(Clegg et al., 1998)

Dp(2;Y)G, Su(var)2-1^v9, Su(var)208^unspecified, lt¹¹ has abnormal eye color phenotype

(Clegg et al., 1998)

Dp(2;Y)G, E(Pc)^unspecified, Su(var)208^unspecified, lt¹¹ has abnormal eye color phenotype

(Clegg et al., 1998)

E(lt^v)319³¹⁹, Su(var)208^unspecified, lt¹¹ has abnormal eye color phenotype

(Clegg et al., 1998)

E(lt^v)335³³⁵, Su(var)208^unspecified, lt¹¹ has abnormal eye color phenotype

(Clegg et al., 1998)

E(lt^v)319³¹⁹, Su(var)208^unspecified, lt¹¹ has partially lethal phenotype

(Clegg et al., 1998)

E(lt^v)335³³⁵, Su(var)208^unspecified, lt¹¹ has partially lethal phenotype

(Clegg et al., 1998)

Su(var)205¹, Su(var)208^unspecified, lt¹/lt¹¹ has partially lethal phenotype

(Clegg et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Su(var)208[+], Su(var)208^unspecified, E(Pc)[+], E(Pc)^unspecified is an enhancer of pigment cell phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)208^unspecified/E(Pc)^unspecified is an enhancer of pigment cell phenotype of lt¹¹

(Clegg et al., 1998)

Su(var)208^unspecified/Su(var)205¹ is an enhancer of pigment cell phenotype of lt¹¹

(Clegg et al., 1998)

Su(var)2-1¹/Su(var)208^unspecified is an enhancer of pigment cell phenotype of lt¹¹

(Clegg et al., 1998)

Su(var)208^unspecified/Su(var)2-1^v9 is an enhancer of pigment cell phenotype of lt¹¹

(Clegg et al., 1998)

Su(var)208[+], Su(var)208^unspecified, Su(var)205[+], Su(var)205¹ is an enhancer of pigment cell phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)2-1[+], Su(var)208[+], Su(var)2-1¹, Su(var)208^unspecified is an enhancer of pigment cell phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)2-1[+], Su(var)208[+], Su(var)208^unspecified, Su(var)2-1^v9 is an enhancer of pigment cell phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Other

Statement

Reference

Su(var)205^unspecified, Su(var)208^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)208^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1¹, Su(var)208^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁴, Su(var)208^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁶, Su(var)208^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

E(Pc)^unspecified, Su(var)208^unspecified, lt¹¹ has pigment cell phenotype

(Clegg et al., 1998)

Dp(2;Y)G, E(Pc)^unspecified, Su(var)208^unspecified, lt¹¹ has pigment cell phenotype

(Clegg et al., 1998)

Su(var)2-1^v9, Su(var)208^unspecified, lt¹¹ has pigment cell phenotype

(Clegg et al., 1998)

Dp(2;Y)G, Su(var)2-1^v9, Su(var)208^unspecified, lt¹¹ has pigment cell phenotype

(Clegg et al., 1998)

E(lt^v)319³¹⁹, Su(var)208^unspecified, lt¹¹ has pigment cell phenotype

(Clegg et al., 1998)

E(lt^v)335³³⁵, Su(var)208^unspecified, lt¹¹ has pigment cell phenotype

(Clegg et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Su(var)205^unspecified shows semi-lethality with Su(var)208^unspecified in females with a Y chromosome.

(Sinclair et al., 2000)

Eye pigmentation in lt¹¹/lt¹ flies is reduced if the flies are also carrying E(Pc)^unspecified/Su(var)208^unspecified, Su(var)208^unspecified/Su(var)205¹, Su(var)208^unspecified/Su(var)2-1¹ or Su(var)2-1^v9/Su(var)208^unspecified. Eye pigmentation in lt¹¹/+ flies that are also carrying E(Pc)^unspecified/Su(var)208^unspecified or Su(var)2-1^v9/Su(var)208^unspecified is reduced. Pigmentation is restored to wild-type levels in these flies by Dp(2;Y)G. lt¹¹/lt¹; Su(var)208^unspecified/Su(var)205¹ flies have reduced viability. Viability is restored in XO males. Eye pigmentation and viability is reduced in lt¹¹/+ flies that are also carrying Su(var)208^unspecified and E(lt^v)319³¹⁹ or Su(var)208^unspecified and E(lt^v)335³³⁵.

(Clegg et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Comments

Originally isolated as a dominant suppressor of the w⁺ gene on In(1)w^m4.

(Hearn et al., 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

208

(Doheny et al., 2008)

Su(var)208^unspecified

unspecified

(Hearn et al., 1991)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections