FlyBase Allele Report: Dmel\rl[unspecified]

General Information

Symbol

Dmel\rl^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0044315

Feature type

allele

Associated gene

Dmel\rl

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Therrien et al., 2000)

visible | recessive

(Hilliker and Holm, 1975, Lewis, 1945)

Phenotype Manifest In

eye

(Lewis, 1945)

midline glial cell

(Bergmann et al., 2002)

wing

(Hilliker and Holm, 1975)

Detailed Description

Statement

Reference

In rl^unspecified mutant embryos, the initial generation of the midline glia (MG) appears to be normal (stage 13) but none survive to stage 17.

(Bergmann et al., 2002)

Rolled wing edges.

(Hilliker and Holm, 1975)

Homozygotes have rough eyes. E(S)¹ has little or no effect on this phenotype in double heterozygotes.

(Lewis, 1945)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

rl[+]/rl^unspecified is an enhancer of lethal phenotype of Raf¹²

(Therrien et al., 2000)

rl[+]/rl^unspecified is an enhancer of visible phenotype of ksr::tor^{ΔNksr.hs.sev}

(Therrien et al., 2000)

Suppressor of

Statement

Reference

rl[+]/rl^unspecified is a suppressor of visible phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Other

Statement

Reference

Su(var)2-1¹, Su(var)205^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁴, Su(var)205^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁴, Su(var)208^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁶, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁶, Su(var)205^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁶, Su(var)208^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)205^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)205^unspecified, Su(var)208^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1¹, Su(var)208^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)208^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1¹/Su(var)2-1²¹⁶, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1¹, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹³, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁴, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

rl^unspecified has phenotype, non-enhanceable by E(S)¹

(Lewis, 1945)

Suppressed by

Statement

Reference

rl^unspecified has midline glial cell phenotype, suppressible by hid^unspecified/hid^unspecified

(Bergmann et al., 2002)

Enhancer of

Statement

Reference

rl[+]/rl^unspecified is an enhancer of eye phenotype of ksr::tor^{ΔNksr.hs.sev}

(Therrien et al., 2000)

NOT Enhancer of

Statement

Reference

rl^unspecified is a non-enhancer of phenotype of Hsap\RALA^G23V.GMR

(Sawamoto et al., 1999)

Suppressor of

Statement

Reference

rl[+]/rl^unspecified is a suppressor of eye phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

NOT Suppressor of

Statement

Reference

rl^unspecified is a non-suppressor of embryonic epidermis | dorsal phenotype of arm³

(McEwen et al., 2000)

rl^unspecified is a non-suppressor of embryonic epidermis | ventral phenotype of arm³

(McEwen et al., 2000)

rl^unspecified is a non-suppressor of phenotype of Hsap\RALA^G23V.GMR

(Sawamoto et al., 1999)

Other

Statement

Reference

Su(var)2-1¹, Su(var)205^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁴, Su(var)205^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁴, Su(var)208^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁶, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁶, Su(var)205^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁶, Su(var)208^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1¹, Su(var)208^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)205^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)205^unspecified, Su(var)208^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)208^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1¹, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1¹/Su(var)2-1²¹⁶, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹³, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁴, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The absence of midline glia (MG) in rl^unspecified embryos is suppressed by W^unspecified/W^unspecified, although the resulting cells are mislocated, lying directly below the cuticle, often in clusters of up to 20 cells. Approximately twice as many MG cells survive as in wild-type.

(Bergmann et al., 2002)

The eye size of rl^unspecified flies is reduced in various combinations with Su(var)2-1¹, Su(var)2-1²¹³, Su(var)2-1²¹⁴, Su(var)2-1²¹⁶, Su(var)205^unspecified or Su(var)208^unspecified. The effects are generally more pronounced in females and by and large appear to be additive.