FlyBase Allele Report: Dmel\tor[13D]

(Margolis et al., 1995, Wimmer et al., 1995, Sprenger and Nusslein-Volhard, 1992, Bronner and Jäckle, 1991, Casanova, 1991, Strecker et al., 1991, Casanova, 1990, Casanova and Struhl, 1989, Pankratz et al., 1989)

loss of function allele

(Sprenger et al., 1993, Eldon and Pirrotta, 1991, Kraut and Levine, 1991)

Mutagen

ethyl methanesulfonate

(Szabad et al., 1989, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Amino acid replacement: Y327C.

(Sprenger et al., 1993, Sprenger and Nusslein-Volhard, 1992)

Tyr at residue 327 (in the extracellular domain) replaced by Cys.

(Sprenger and Nusslein-Volhard, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:7,707,563..7,707,563 [-]

Nucleotide change:

A7707563G

Reported nucleotide change:

A?G

Amino acid change:

Y327C | tor-PA; Y327C | tor-PD

Reported amino acid change:

Y327C

(Sprenger and Nusslein-Volhard, 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of movement | dominant

(Eldon and Pirrotta, 1991)

female sterile | dominant

(Casanova and Struhl, 1989)

female sterile germline-dependent | dominant

(Szabad et al., 1989)

increased rate of movement | dominant

(Strecker et al., 1991)

lethal | cold sensitive

(Dickson et al., 1992)

Phenotype Manifest In

embryo

(Goyal et al., 2017)

embryonic/first instar larval cuticle

(Luschnig et al., 2000, Strecker et al., 1991)

embryonic/first instar larval cuticle | maternal effect

(Li and Li, 2003)

endoderm

(Tepass and Hartenstein, 1994)

visceral mesoderm

(Tepass and Hartenstein, 1994)

Detailed Description

Statement

Reference

tor^13D mutant embryos display a highly penetrant pole-hole phenotype.

(Goyal et al., 2017)

At 22^oC, embryos derived from heterozygous females differentiate only rudimentary cuticle structures.

(Li and Li, 2003)

Visceral mesoderm of the trunk, which normally gives rise to the visceral muscles of the midgut is absent. The posterior portion of the mesoderm produces visceral muscle fibres which attach to the hindgut epithelium. A fraction of the endoderm cells, which contacts the visceral mesoderm underlying the hindgut, takes on epithelial characteristics.

(Tepass and Hartenstein, 1994)

Embryos lack anteriormost head structures.

(Eldon and Pirrotta, 1991)

The abdominal gt stripe extends all the way to the posterior pole, the anterior-most head patch of gt disappears and the remainder of the gt pattern is expanded and shifted.

(Kraut and Levine, 1991)

Embryos derived from heterozygous females develop normally up to the blastoderm stage. At 18^oC only the most posterior larval structures develop. At higher temperatures, posterior abdominal segments and anterior head segments may develop in a fraction of the embryos.

(Szabad et al., 1989)

dominant

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

tor^13D has embryonic/first instar larval cuticle | maternal effect phenotype, enhanceable by dpp^P23

(Li and Li, 2003)

tor^13D has embryonic/first instar larval cuticle phenotype, enhanceable by dpp^hr4

(Strecker et al., 1991)

Suppressed by

Statement

Reference

tor^13D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by dpp^H46/dpp[+]

(Li and Li, 2003)

tor^13D has abdominal 11 anal tuft phenotype, suppressible by Shc^111-40

(Luschnig et al., 2000)

tor^13D has embryonic/first instar larval cuticle phenotype, suppressible by Shc^111-40

(Luschnig et al., 2000)

tor^13D has filzkorper phenotype, suppressible by Shc^111-40

(Luschnig et al., 2000)

tor^13D has abdominal 11 anal tuft phenotype, suppressible by Shc^BG

(Luschnig et al., 2000)

tor^13D has embryonic/first instar larval cuticle phenotype, suppressible by Shc^BG

(Luschnig et al., 2000)

tor^13D has filzkorper phenotype, suppressible by Shc^BG

(Luschnig et al., 2000)

tor^13D has embryonic/first instar larval cuticle phenotype, suppressible by dos^P115

(Luschnig et al., 2000)

tor^13D has embryonic/first instar larval cuticle phenotype, suppressible by gt^A8

(Strecker et al., 1991)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygous females carrying tor^13D produce embryos that produce very little cuticle. This phenotype is weakly suppressed if the females are carrying one copy of Shc^111-40 or Shc^BG; the embryos develop more cuticle and show posterior structures such as Filzkorper and Tuft structures. The phenotype is completely suppressed if the tor^13D/+ females also carry homozygous Shc^111-40 or Shc^BG germline clones; embryos look normal and can hatch. dos^P115 partially suppresses the phenotype of embryos derived from tor^13D/+ females.

(Luschnig et al., 2000)

The embryonic phenotype is suppressed by gt^A8 : there is an increase in the proportion of embryos that form cuticle and a decrease in the proportion of embryos that form empty sacs.

(Strecker et al., 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Szabad.

Comments

Analysis of germ-line chimeras shows that this mutation is germ-line- dependent.

(Szabad et al., 1989)

Constitutively active tor protein.

(Reichman-Fried et al., 1994)

Constitutive, ligand-independent activation of tor gene product.

(Rusch and Levine, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Tor⁴⁰²¹

(Luschnig et al., 2000)

Tor^D4021

(Keenan et al., 2020, Goyal et al., 2017, Johnson et al., 2017)

Torso⁴⁰²¹

(Gabay et al., 1997)

tor^13D

(Florence and Faller, 2008)

tor^D4021

(Grimm et al., 2012, de las Heras and Casanova, 2006, Rudolph et al., 1997, Rothe et al., 1994, Steingrimsson et al., 1991, Casanova, 1990, Pawson and Bernstein, 1990, Casanova and Struhl, 1989, Szabad et al., 1989)

tor^D4201

(Singer et al., 1996, Liaw et al., 1995, Liaw and Lengyel, 1993, Kraut and Levine, 1991)

torso⁴⁰²¹

(Ajuria et al., 2011, Lai et al., 1995)

Name Synonyms

Secondary FlyBase IDs

FBal0046603

References (59)

Report Sections

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