FlyBase Allele Report: Dmel\bol[1]

(Fingerhut et al., 2019, Hoopfer et al., 2008, Sofola et al., 2007, Andrade and Cook, 2003.6.2, Spradling et al., 1999, BDGP Project Members, 1994-1999, Castrillon et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle

(Eberhart et al., 1996, Castrillon et al., 1993)

abnormal meiotic cell cycle | male

(Maines and Wasserman, 1999)

male sterile | recessive

(Spradling et al., 1999, Santel et al., 1997, Eberhart et al., 1996, Castrillon et al., 1993)

Phenotype Manifest In

germline cell | male

(Santel et al., 1997)

Nebenkern

(Castrillon et al., 1993)

primary spermatocyte cyst

(Eberhart et al., 1996, Castrillon et al., 1993)

spindle | male

(Maines and Wasserman, 1999)

testis

(Eberhart et al., 1996, Castrillon et al., 1993)

Detailed Description

Statement

Reference

Meiotic entry is blocked, meiotic spindles do not form.

(Maines and Wasserman, 1999)

The testes of homozygous males contain only premeiotic germ cell stages.

(Santel et al., 1997)

In homozygotes, spermatocytes form but fail to undergo meiotic divisions. 64-cell spermatid cysts are absent. BrdU labeling shows that mitotic and premeiotic S phases occur as in wild-type, and meiotic prophase is normal. Subsequent stages of meiosis are aberrant. Chromosomes remain at the nuclear periphery, and centrosome separation occurs but the centrosomes do not reach the poles and do not nucleate asters. The nuclear lamina fails to break down. Spermiogenesis continues to a limited extent. Mitochondria begin to form nebenkern in tetraploid spermatids. Hemizygous males show minor but reproducible defects in spermatogenesis.

(Eberhart et al., 1996)

Some 16-cell cysts resemble those of pelo, with no meiosis and abnormally large Nebenkern in late spermatocytes; others contain multiple nuclei as well as large Nebenkern.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

bol¹ has abnormal meiotic cell cycle | male phenotype, suppressible by twe^βTub85D.PM

(Maines and Wasserman, 1999)

Phenotype Manifest In

Suppressed by

Statement

Reference

bol¹ has spindle | male phenotype, suppressible by twe^βTub85D.PM

(Maines and Wasserman, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11794

P{PZ}bol¹ ry⁵⁰⁶/TM6B, Tb¹

Kyoto

101719

P{PZ}bol¹ ry⁵⁰⁶ / TM3, ry^RK Sb¹

Notes on Origin

Discoverer

A. Spradling.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

BOL

(Sofola et al., 2007)

bol⁰⁷²⁷²

bol¹

(Williams et al., 2016, Xu et al., 2012, Rautureau et al., 2009, Christensen et al., 2007.10.29, Sofola et al., 2007, Gresens et al., 2006.7.11, Mikhaylova et al., 2006)

boule¹

(Hempel et al., 2006)

ms(3)07272

(Spradling et al., 1999)

ms(3)07272⁰⁷²⁷²

Name Synonyms

Secondary FlyBase IDs

References (21)

Report Sections

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