FB2024_03 , released June 25, 2024
Allele: Dmel\Arl11
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General Information
Symbol
Dmel\Arl11
Species
D. melanogaster
Name
FlyBase ID
FBal0028993
Feature type
allele
Associated gene
Dmel\Arl1
Associated Insertion(s)
Carried in Construct
Also Known As
arf72A1
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Torres et al., 2014)
Mutagen
ethyl methanesulfonate
(Tamkun et al., 1991)
Progenitor genotype
Cytology
Description

Amino acid replacement: G2D.

(Torres et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:15,983,378..15,983,378 [+]
Nucleotide change:

G15983378A

Amino acid change:

G2D | Arl1-PA

Reported amino acid change:

G2D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Torres et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The structure of the Golgi and cell polarity are not affected in Arl11 cell clones.

      Arl11 clones in the wing disc show increased apoptosis. This phenotype is not seen in follicle cell or salivary gland clones.

      Arl12/Arl11 larval salivary glands have more secretory granules of significantly smaller size, compared to controls.

      (Torres et al., 2014)

      Arf72A1 cells within a mutant retinal clone show proliferated internal membranes. Most strikingly, rough endoplasmic reticulum-type membranes are greatly expanded, swollen and have more pronounced heterogeneity compared to wild type.

      Arf72A1 eye cells have extensive Golgi structures both in size and number throughout the cytoplasm compared to wild type.

      (Lee et al., 2011)

      Centrosome maturation proceeds normally in most mutant embryos through the early syncytial blastoderm but a low percentage of centrosomes are either small or fused. During the late syncytial blastoderm stage, the number of centrosome and nuclear fusions increases. Approximately 63% of embryos complete cellularization and initiate gastrulation prior to failure, but furrow- and segment-formation is weak or incomplete, giving the cortex a smooth, flat appearance. Mitotic domains have fewer cells than in wild type and many spindles have a single centrosome. The nuclear density is low in these embryos and many nuclei appear to be aneuploid.

      (Eisman et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Arfip12/Arl11 third instar larvae have significantly fewer boutons at the neuromuscular junction compared to Arfip12/+ or Arl11/+ heterozygotes.

      (Chang et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Arl11/Arl12 is rescued by Arl1+t2.5

      (Torres et al., 2014)

      Arl11 is rescued by Arl1+t2.5

      (Brizuela et al., 1994)

      Arl11 is rescued by Arl1+t10.8

      (Brizuela et al., 1994)

      Arl11 is rescued by Arl1+t2.5

      (Tamkun et al., 1991)
      Comments

      Arl1+t2.5 rescues the secretory granule defects in Arl12/Arl11 salivary glands.

      (Torres et al., 2014)

      Homozygotes are completely rescued by Arf72A+t2.5, carried by P{arl2.5}.

      (Tamkun et al., 1991)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Arf72A1
      (Eisman et al., 2006, Armstrong et al., 2005)
      Arl11
      (Wang et al., 2017, Chang et al., 2015)
      arf72A1
      (Lee et al., 2011)
      arl11
      (Torres et al., 2014)
      arl1
      (Tamkun et al., 1991)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)