FlyBase Allele Report: Dmel\BicD[D]

General Information

Symbol

Dmel\BicD^D

Species

D. melanogaster

Name

FlyBase ID

FBal0029055

Feature type

allele

Associated gene

Dmel\BicD

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die

(Navarro et al., 2004)

some die during embryonic stage

(Navarro et al., 2004)

Phenotype Manifest In

embryonic/first instar larval cuticle

(Navarro et al., 2004)

embryonic abdomen | anterior

(Mach and Lehmann, 1997)

embryonic abdomen | ectopic | posterior

(Mach and Lehmann, 1997)

embryonic head

(Mach and Lehmann, 1997)

Detailed Description

Statement

Reference

BicD^D mutants exhibit a dominant bicaudal phenotype, resulting in a low larval hatch rate (approximately 26% in BicD^D heterozygotes) and embryonic segmentation defects.

(Navarro et al., 2004)

Females produce embryos with reduced head structures. In the most extreme case double abdomen (or bicaudal embryos) develop in which ectopic posterior structures replace anterior structures.

(Mach and Lehmann, 1997)

Bicaudal phenotype: lack anterior structures and have two posterior ends. The posterior signal is localized to the anterior and posterior ends.

(Lehmann and Nusslein-Volhard, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

BicD^D has partially lethal - majority die | embryonic stage phenotype, enhanceable by btz²

(Navarro et al., 2004)

BicD^D has partially lethal - majority die | embryonic stage phenotype, enhanceable by Khc⁸

(Navarro et al., 2004)

Suppressed by

Statement

Reference

BicD^D, stau^unspecified has partially lethal - majority die | embryonic stage phenotype, suppressible by ctp^exc3

(Navarro et al., 2004)

BicD^D has partially lethal - majority die | embryonic stage phenotype, suppressible | partially by stau^unspecified/ctp^exc3

(Navarro et al., 2004)

BicD^D, stau^unspecified has partially lethal - majority die | embryonic stage phenotype, suppressible by Lis-1^G10.14

(Navarro et al., 2004)

BicD^D has partially lethal - majority die | embryonic stage phenotype, suppressible | partially by stau^unspecified/Lis-1^G10.14

(Navarro et al., 2004)

BicD^D, stau^unspecified has partially lethal - majority die | embryonic stage phenotype, suppressible by egl^3e

(Navarro et al., 2004)

BicD^D has partially lethal - majority die | embryonic stage phenotype, suppressible by egl^3e/stau^unspecified

(Navarro et al., 2004)

BicD^D, stau^unspecified has partially lethal - majority die | embryonic stage phenotype, suppressible by Dhc64C^4-19

(Navarro et al., 2004)

BicD^D has partially lethal - majority die | embryonic stage phenotype, suppressible by Dhc64C^4-19/stau^unspecified

(Navarro et al., 2004)

Other

Statement

Reference

BicD^D, stau^unspecified has partially lethal - majority die | embryonic stage phenotype

(Navarro et al., 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

BicD^D has embryonic/first instar larval cuticle phenotype, suppressible | partially by stau^unspecified/ctp^exc3

(Navarro et al., 2004)

BicD^D, stau^unspecified has embryonic/first instar larval cuticle phenotype, suppressible by ctp^exc3

(Navarro et al., 2004)

BicD^D has phenotype, suppressible by egl^2b

(Mach and Lehmann, 1997)

BicD^D has phenotype, suppressible by egl^2e

(Mach and Lehmann, 1997)

BicD^D has phenotype, suppressible by egl^3e

(Mach and Lehmann, 1997)

BicD^D has phenotype, suppressible by egl^4e

(Mach and Lehmann, 1997)

Additional Comments

Genetic Interactions

Statement

Reference

BicD^D stau^unspecified / egl^3e triple mutants exhibit a 46% hatch-rate, compared to BicD^D stau^unspecified double mutants, which exhibit a hatch-rate of 19%. This indicates suppression of the BicD^D stau^unspecified phenotype by egl^3e.

BicD^D stau^unspecified/Dhc64C^4-19 triple mutants exhibit a 39% hatch-rate, compared to BicD^D stau^unspecified double mutants, which exhibit a hatch-rate of 8%. This indicates suppression of the BicD^D stau^unspecified phenotype by Dhc64C^4-19.

BicD^D stau^unspecified / ctp^exc3 triple mutants exhibit a 0.7% hatch-rate, compared to 0.25% in BicD^D stau^unspecified mutants. This indicates a mild suppression of the BicD^D stau^unspecified by ctp^exc3. Removing one copy of ctp^exc3 suppresses the 'double abdomen' phenotype of BicD^D stau^unspecified and allows more wild-type cuticle to form. The percentage of embryos exhibiting a bicaudal phenotype decreases from 97% (BicD^D stau^unspecified) to 57% (BicD^D stau^unspecified/ctp^exc3). This coincides with an increase in the number of asymmetric, headless and normal embryos.

BicD^D/ctp^exc3 double mutants exhibit a 39% hatch-rate, compared to 2% in BicD^D mutants. This indicates suppression of the BicD^D stau^unspecified mutant phenotype by ctp^exc3.

BicD^D stau^unspecified/Lis-1^G10.14 triple mutants exhibit a 85% hatch-rate, compared to an 8% hatch-rate in BicD^D stau^unspecified control strains. This indicates suppression of the BicD^D stau^unspecified phenotype by Lis-1^G10.14.

BicD^D/btz² double mutants exhibit a hatch-rate of 24%, compared to a hatch-rate of 60% in BicD^D control strains. This decrease in hatch-rate indicates an enhancement of the BicD^D phenotype by btz².

BicD^D/Khc⁸ double mutants exhibit a hatch-rate of 3%, compared to a hatch-rate of 16% in BicD^D control strains. This decrease in hatch-rate indicates an enhancement of the BicD^D phenotype by Khc⁸.

(Navarro et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Bic-D^D

(St. Johnston, 1993)

BicD^D

(Navarro et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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