FlyBase Allele Report: Dmel\stau[unspecified]

General Information

Symbol

Dmel\stau^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0065675

Feature type

allele

Associated gene

Dmel\stau

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Schupbach and Wieschaus, 1989)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Schupbach and Wieschaus, 1989)

grandchildless | recessive

(Schupbach and Wieschaus, 1989)

lethal | maternal effect

(Schuldt et al., 1998)

lethal - all die during embryonic stage | maternal effect | recessive

(Schupbach and Wieschaus, 1989)

some die during embryonic stage | recessive | maternal effect | recessive

(Schupbach and Wieschaus, 1989)

Phenotype Manifest In

cephalic furrow | maternal effect

(Schupbach and Wieschaus, 1989)

embryonic abdominal segment 1

(Tearle and Nusslein-Volhard, 1987)

embryonic abdominal segment 2

(Tearle and Nusslein-Volhard, 1987)

embryonic abdominal segment 3

(Tearle and Nusslein-Volhard, 1987)

embryonic abdominal segment 4

(Tearle and Nusslein-Volhard, 1987)

embryonic abdominal segment 5

(Tearle and Nusslein-Volhard, 1987)

embryonic abdominal segment 6

(Tearle and Nusslein-Volhard, 1987)

embryonic abdominal segment 7

(Tearle and Nusslein-Volhard, 1987)

embryonic abdominal segment 8

(Tearle and Nusslein-Volhard, 1987)

embryonic abdominal segment 9

(Tearle and Nusslein-Volhard, 1987)

embryonic abdominal segment 10

(Tearle and Nusslein-Volhard, 1987)

embryonic abdominal segment 11

(Tearle and Nusslein-Volhard, 1987)

embryonic abdominal segment | maternal effect

(Schupbach and Wieschaus, 1989)

embryonic head | anterior

(Tearle and Nusslein-Volhard, 1987)

embryonic head | anterior | maternal effect

(Schupbach and Wieschaus, 1989)

pole granule | maternal effect

(Schupbach and Wieschaus, 1989)

pole plasm

(Tearle and Nusslein-Volhard, 1987)

primordial germ cell

(Tearle and Nusslein-Volhard, 1987)

primordial germ cell | maternal effect

(Schupbach and Wieschaus, 1989)

Detailed Description

Statement

Reference

Eggs derived from homozygous females show a "grandchildless knirps-like" phenotype; they lack polar granules and pole cells and show deletions of abdominal segments similar to that seen in kni mutant embryos. In addition, the cephalic furrow is shifted anteriorly at gastrulation, and deletions of anterior head structures are seen in the cuticle.

(Schupbach and Wieschaus, 1989)

Embryos derived from stau^unspecified mutant females lack pole cells, pole plasm and abdominal segments. The anterior part of the head is defective.

(Tearle and Nusslein-Volhard, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

BicD^D, stau^unspecified has partially lethal - majority die | embryonic stage phenotype, suppressible by egl^3e

(Navarro et al., 2004)

BicD^D, stau^unspecified has partially lethal - majority die | embryonic stage phenotype, suppressible by Dhc64C^4-19

(Navarro et al., 2004)

BicD^D, stau^unspecified has partially lethal - majority die | embryonic stage phenotype, suppressible by ctp^exc3

(Navarro et al., 2004)

BicD^D, stau^unspecified has partially lethal - majority die | embryonic stage phenotype, suppressible by Lis-1^G10.14

(Navarro et al., 2004)

Suppressor of

Statement

Reference

egl^3e/stau^unspecified is a suppressor of partially lethal - majority die | embryonic stage phenotype of BicD^D

(Navarro et al., 2004)

Dhc64C^4-19/stau^unspecified is a suppressor of partially lethal - majority die | embryonic stage phenotype of BicD^D

(Navarro et al., 2004)

stau^unspecified/ctp^exc3 is a suppressor | partially of partially lethal - majority die | embryonic stage phenotype of BicD^D

(Navarro et al., 2004)

stau^unspecified/Lis-1^G10.14 is a suppressor | partially of partially lethal - majority die | embryonic stage phenotype of BicD^D

(Navarro et al., 2004)

Other

Statement

Reference

BicD^D, stau^unspecified has partially lethal - majority die | embryonic stage phenotype

(Navarro et al., 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

BicD^D, stau^unspecified has embryonic/first instar larval cuticle phenotype, suppressible by ctp^exc3

(Navarro et al., 2004)

NOT Enhancer of

Statement

Reference

stau^unspecified/stau[+] is a non-enhancer of embryo | embryonic cycle 14 | maternal effect phenotype of CycB^+t10

(Ji et al., 2005)

Suppressor of

Statement

Reference

stau^unspecified/ctp^exc3 is a suppressor | partially of embryonic/first instar larval cuticle phenotype of BicD^D

(Navarro et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

BicD^D stau^unspecified / egl^3e triple mutants exhibit a 46% hatch-rate, compared to BicD^D stau^unspecified double mutants, which exhibit a hatch-rate of 19%. This indicates suppression of the BicD^D stau^unspecified phenotype by egl^3e.

BicD^D stau^unspecified/Dhc64C^4-19 triple mutants exhibit a 39% hatch-rate, compared to BicD^D stau^unspecified double mutants, which exhibit a hatch-rate of 8%. This indicates suppression of the BicD^D stau^unspecified phenotype by Dhc64C^4-19.

BicD^D stau^unspecified / ctp^exc3 triple mutants exhibit a 0.7% hatch-rate, compared to 0.25% in BicD^D stau^unspecified mutants. This indicates a mild suppression of the BicD^D stau^unspecified by ctp^exc3. Removing one copy of ctp^exc3 suppresses the 'double abdomen' phenotype of BicD^D stau^unspecified and allows more wild-type cuticle to form. The percentage of bicaudal decreases from 97% (BicD^D stau^unspecified) to 57% (BicD^D stau^unspecified/ctp^exc3). This coincides with an increase in the number of asymmetric, headless and normal embryos.

BicD^D stau^unspecified/Lis-1^G10.14 triple mutants exhibit a 85% hatch-rate, compared to an 8% hatch-rate in BicD^D stau^unspecified control strains. This indicates suppression of the BicD^D stau^unspecified phenotype by Lis-1^G10.14.

(Navarro et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

stau^unspecified is rescued by stau^{αTub67C.mGFP6}

(Schuldt et al., 1998)

stau^unspecified is rescued by stau^+t16.3

(St. Johnston et al., 1991)

Comments

The maternal effect lethality of stau^unspecified is rescued by stau^{αTub67C.T:Avic\GFP-m6}.

(Schuldt et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

stau^unspecified

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

Open Close