FB2024_03 , released June 25, 2024
Allele: Dmel\jumuD631
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General Information
Symbol
Dmel\jumuD631
Species
D. melanogaster
Name
FlyBase ID
FBal0029714
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

The P{lArB} insertion is at bp 6185 (where 1 is at transcription start).

Allele components
Component
Use(s)
Inserted element
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Polytene chromosomes from homozygous third instar larvae show loss of a significant breakage and scattering of the normally circular-shaped nucleolus, with nucleolar material being widely spread and/or attached to many distinct sites on the euchromatic chromosome arms. The euchromatic arms are smaller than in control larvae due to reduced polytenisation.

jumuD631/+ significantly suppresses the position effect variegation of the w gene seen in the T(2;3)P(GawB)94E line, resulting in a conspicuous increase in eye pigmentation.

Dominant suppressor of PEV in In(1)wm4. In homozygous adult escapers a number of phenotypes are seen. A disordered hair and bristle arrangements are seen at the scutellum and the wing margins. In most cases flies show loss or doubling of macrochaetae, however bristles appear to be at correct positions. jumuD631/jumuD631 wings are reduced in size, hairs are irregularly places, posterior wing margins are notched and L5 is sometimes shortened. In some cases wings are extended. The eyes in jumuD631/jumuD631 mutants are smaller than wild-type and have a rough eye phenotype, adjacent ommatidia are often fused and the eyes are composed of ommatidia of variable size and shape.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of Hsap\FOXN1Scer\UAS.cHa under the control of Scer\GAL4hs.PB does not rescue the jumuD631 homozygous phenotype; most animals die as young larvae and only a few escapers reach the third larval stage.

Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Strong enhancer. High spontaneous background rate of E(var) mutations in these experiments allows for the possibility that the P insertion is not the cause of the E(var) phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)