FB2024_03 , released June 25, 2024
Allele: Hsap\FOXN1UAS.cHa
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General Information
Symbol
Hsap\FOXN1UAS.cHa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Hofmann
FlyBase ID
FBal0246401
Feature type
allele
Associated gene
Hsap\FOXN1
Associated Insertion(s)
Carried in Construct
P{UAS-hwhn.H}
Key Links
Transgenic product class
wild_type
(Hofmann et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Hofmann et al., 2010)
Mutagen
in vitro construct
(Hofmann et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-hwhn.H}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\FOXN1.

(Hofmann et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\FOXN1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\FOXN1Scer\UAS.cHa under the control of Scer\GAL4Sgs4.PH does not result in alterations in the morphology of the polytene chromosomes or the nucleolus in larval salivary glands.

      Expression of Hsap\FOXN1Scer\UAS.cHa under the control of Scer\GAL4hs.PB at 18[o]C results in the macrochaetae being very long, pale and fragile. The phenotype is more apparent when the flies are continuously bred at 30[o]C.

      (Hofmann et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Hsap\FOXN1UAS.cHa/Scer\GAL4hs.PB is a non-suppressor of lethal phenotype of jumuD631

      (Hofmann et al., 2010)

      Hsap\FOXN1UAS.cHa/Scer\GAL4hs.PB is a non-suppressor of lethal phenotype of jumu3.4

      (Hofmann et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\FOXN1Scer\UAS.cHa under the control of Scer\GAL4hs.PB does not rescue the jumuD631 or jumu3.4 homozygous phenotype; most animals die as young larvae and only a few escapers reach the third larval stage.

      (Hofmann et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\FOXN1Scer\UAS.cHa
      Hsap\FOXN1UAS.cHa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Hofmann
      Secondary FlyBase IDs
        References (1)