FlyBase Allele Report: Dmel\N[XK11]

General Information

Symbol

Dmel\N^XK11

Species

D. melanogaster

Name

FlyBase ID

FBal0029958

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

Also Known As

N^XK

Key Links

Allele class

amorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Dominguez et al., 2004, Tomlinson and Struhl, 1999, Lieber et al., 1993, Struhl et al., 1993, Hoppe and Greenspan, 1990)

hypomorphic allele - genetic evidence

(Brennan et al., 1997)

Mutagen

Progenitor genotype

Cytology

Description

Mutation is outside the protein coding sequences.

(Brennan et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant

(Domanitskaya and Schüpbach, 2012, Shyamala and Chopra, 1999)

visible | dominant | neurogenic phenotype

(Brennan et al., 1997)

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygotes show notching of the wing blade.

(Domanitskaya and Schüpbach, 2012)

N^XK11/+ mutants have an increased number of scutellar macrochaetae compared to wild type.

(Wildonger and Mann, 2005)

Clones of cells in the eye disc carrying N^XK11 that are produced in the first and second larval stages are often smaller than corresponding wild-type clones in the dorsal-ventral region.

(Dominguez et al., 2004)

Homozygous mutant clones fail to contribute to bristle forming portions of the adult epidermis (the segmental regions anterior 3, 4 and 5 (a3, a4 and a5)) of the adult abdomen, they survive elsewhere where they show normal polarity.

(Lawrence et al., 2002)

Mutant embryos have a dramatically expanded population of vg-expressing muscle founder cells compared to wild-type.

(Bour et al., 2000)

The number of ftz expressing MP2 neurons increases compared to wild-type (About 30 on each side of the midline, as compared to 2 in wild-type) in homozygous embryos derived from homozygous female germ-line clones (lacking both maternal and zygotic function). The extra MP2 clusters extend further laterally than seen in Dl and Su(H). alleles. No segmentation defects are seen. In homozygous embryos derived from homozygous female germ-line clones (lacking both maternal and zygotic function), clusters of 10 to 15 eve-expressing RP2-like cells are found in place of the normal RP2. These clusters often merge across the midline into a large cluster of 20 to 30 cells, apparently displacing or replacing the cell types that normally occupy the midline.

(Rusconi and Corbin, 1999)

Heterozygotes have small notches at the tip of the wing.

(Shyamala and Chopra, 1999)

The number of cells in the nau-expressing muscle precursor clusters is increased compared to wild-type in homozygous embryos. The medial clusters expand longitudinally. The number of cells in the nau-expressing muscle precursor clusters is increased to more than twice the number in homozygous embryos (lacking zygotic function) in homozygous embryos derived from homozygous female germline clones (lacking both maternal and zygotic function). The number of cells in the slou-expressing muscle precursor clusters is increased compared to wild-type in homozygous embryos. The number of cells in the slou-expressing muscle precursor clusters is further increased in homozygous embryos derived from homozygous female germline clones (lacking both maternal and zygotic function), and the arrangement of the clusters is altered in these embryos, with extremely large clusters of slou-expressing cells lying on either side of the midline.

(Rusconi and Corbin, 1998)

Hemizygous lethal. Heterozygotes have a neurogenic phenotype and have an increase in the number of thoracic bristles compared to wild-type. The number of bristles is restored almost to wild-type in N^XK11 ; Dp(1;2)51b double heterozygotes.

(Brennan et al., 1997)

No ventral cuticle.

(Lieber et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

N^XK11 has visible | dominant phenotype, enhanceable by sd[+]/sd^SG29.1

(Shyamala and Chopra, 1999)

N^XK11 has visible | dominant phenotype, enhanceable by Df(3R)Delta-FX3

(Brennan et al., 1997)

Suppressed by

Statement

Reference

N^XK11 has visible | dominant phenotype, suppressible by wg^S107

(Brennan et al., 1997)

Other

Statement

Reference

CoRest[+]/CoRest^GF60, N^XK11 has visible | dominant phenotype

(Domanitskaya and Schüpbach, 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

N^XK11 has scutellar bristle | increased number phenotype, enhanceable by Df(2R)nvy^PDFKG1/+

(Wildonger and Mann, 2005)

N^XK11 has wing phenotype, enhanceable by sd[+]/sd^SG29.1

(Shyamala and Chopra, 1999)

N^XK11 has adult thoracic sensillum phenotype, enhanceable by Df(3R)Delta-FX3

(Brennan et al., 1997)

Suppressed by

Statement

Reference

N^XK11 has phenotype, suppressible by N::sev^{Sev11.GV.4.hs}

(Struhl and Adachi, 1998)

N^XK11 has adult thoracic sensillum phenotype, suppressible by wg^S107

(Brennan et al., 1997)

NOT suppressed by

Statement

Reference

N^XK11 has phenotype, non-suppressible by N::sev^{Sev11.GV.3.hs}

(Struhl and Adachi, 1998)

N^XK11 has phenotype, non-suppressible by Scer\GAL4^{VP16.F442A.αTub84B}/N::sev^{UAS.Tag:HA,Tag:NLS(SV40-largeT)}

(Struhl and Adachi, 1998)

Other

Statement

Reference

CoRest[+]/CoRest^GF60, N^XK11 has wing vein phenotype

(Domanitskaya and Schüpbach, 2012)

CoRest[+]/CoRest^GF60, N^XK11 has wing blade phenotype

(Domanitskaya and Schüpbach, 2012)

N^XK11, sd[+]/sd^SG29.1 has wing vein phenotype

(Shyamala and Chopra, 1999)

N^XK11, sd^SG29.1 has wing vein phenotype

(Shyamala and Chopra, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

CoRest^GF60/N^XK11 transheterozygotes show thickened wing veins and deltas. Wing blistering is occasionally seen.

(Domanitskaya and Schüpbach, 2012)

N^XK11/+; Df(2R)nvy^PDFKG1/+ have greater numbers of scutellar macrochaetae than N^XK11/+ single mutants.

(Wildonger and Mann, 2005)

N^XK11/sd^SG29.1 double heterozygotes show enhancement of nicking along the tip of the wing (compared to N^XK11 single heterozygotes) and the veins show delta-like thickening at the end.

(Shyamala and Chopra, 1999)

The number of thoracic bristles is increased further if the flies are also heterozygous for Df(3R)Dl-FX3, and the number of bristles is restored almost to wild-type in N^XK11 ; wg^S107 double heterozygotes.

(Brennan et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

N^XK11 is rescued by N^VL.GV.3.hs

(Struhl and Adachi, 2000)

N^XK11 is rescued by N^GV.3.hs

(Struhl and Adachi, 2000)

N^XK11 is rescued by N^ECN.GV.3.hs

(Struhl and Adachi, 2000)