FlyBase Allele Report: Dmel\fu[RX15]

General Information

Symbol

Dmel\fu^RX15

Species

D. melanogaster

Name

FlyBase ID

FBal0031367

Feature type

allele

Associated gene

Dmel\fu

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Therond et al., 1996, Preat et al., 1993)

Progenitor genotype

Cytology

Description

Deletion of genomic sequences 2398-2399, only the first 474 amino acids are present followed by 7 new amino acids.

(Therond et al., 1996)

Mutation in the putative regulatory domain. Class II fu allele, affects the carboxy domain of the protein by changing the open reading frame in the 5' region.

(Preat et al., 1993)

Associated with a rearrangement (not described) outside the putative kinase domain.

(Preat et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

X:18,659,334..18,659,335 [+]

Comment:

Substitution of two nucleotides by nine others (TTCTCAGTT).

Inserted_sequence:

TTCTCAGTT

(Therond et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Glise et al., 2002)

Phenotype Manifest In

wing vein L3 | distal

(Glise et al., 2002)

wing vein L3 | proximal

(Glise et al., 2002)

Detailed Description

Statement

Reference

Mutants show fusion of wing veins L3 and L4 both proximally and distally, with intervein tissue remaining between the two veins in the medial part of the wing.

(Glise et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

fu^RX15 has phenotype, enhanceable by Su(fu)^LP

(Preat et al., 1993)

Other

Statement

Reference

Su(fu)^LP, fu^RX15 has wing phenotype

(Preat et al., 1993)

Su(fu)^LP, fu^RX15 has leg phenotype

(Preat et al., 1993)

Su(fu)^LP, fu^RX15 has haltere phenotype

(Preat et al., 1993)

Su(fu)^LP, fu^RX15 has wing blade anterior compartment phenotype

(Preat et al., 1993)

Su(fu)^LP, fu^RX15 has leg anterior compartment phenotype

(Preat et al., 1993)

Su(fu)^LP, fu^RX15 has haltere anterior compartment phenotype

(Preat et al., 1993)

Additional Comments

Genetic Interactions

Statement

Reference

When in combination with Su(fu)^LP or cos³ heterozygotes individuals die as pupae. Adult escapers display wings, halteres and legs that have duplication of structures in the anterior compartment and shortening along the proximal-distal axis. Embryos derived from heterozygotes with Su(fu) mutants display a segment polarity phenotype: thoracic denticle belts are absent, last two rows of abdominal denticle belts are absent and a mirror image duplication of anterior rows of abdominal denticle belts.

(Preat et al., 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Class II mutation based on interaction with Su(fu)^LP, suppression of embryonic and adult phenotype but display an additional phenotype.

(Therond et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fu^RX15

fu^XR15

(Wang and Holmgren, 1999)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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