FB2024_03 , released June 25, 2024
Allele: Dmel\grkED22
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General Information
Symbol
Dmel\grkED22
Species
D. melanogaster
Name
FlyBase ID
FBal0031409
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Amino acid replacement: G?S. Nucleotide substitution: G2138A.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

G8431979A

Reported nucleotide change:

G2138A

Amino acid change:

G196S | grk-PA

Reported amino acid change:

G?S

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Eggs derived from homozygous females dispay fused dorsal appendage that is narrower than a single appendage. Eggs derived from heterozygous mothers are completely wild type. brnfs.107/brn+; grkED22/grk+ females display large gaps in the follicular epithelium, frequently uncovering over half of the egg chamber exposing the nurse cells. Eggs derived from these females display dorsal appendages fused at the base with two appendages apparent, indistinguishable from a weak brn eggshell phenotype (intermediate or strong ventralised phenotype).

Eggs produced by fs(1)K10LM00 grkED22 or fs(1)K101 grkED22 double mutant females are more ventralised than eggs produced by grkED22 single mutant females. Most double mutant eggs contain no or only a node of dorsal appendage material positioned on the dorsal midline, whereas grkED22 single mutant eggs have at least one dorsal appendage that usually extends anteriorly beyond the anterior tip of the egg.

Weak ventralization of embryos. Filzkorper are normal. Only one dorsal appendage forms. 51% of laid eggs contain embryos. Mesoderm is wider than usual and cannot be enveloped by remaining epidermis. Two ventral furrows form.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

grkED22 has dorsal appendage phenotype, non-enhanceable by LnkCR642

NOT suppressed by
Statement
Reference

grkED22 has dorsal appendage phenotype, non-suppressible by LnkCR642

Additional Comments
Genetic Interactions
Statement
Reference

Eggs laid by LnkCR642 ; grkED22 females are indistinguishable from those laid by grkED22 single mutant females, and all have a single dorsal appendage.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Weak mutation.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)