Amino acid replacement: G?S. Nucleotide substitution: G2138A.
G8431979A
G2138A
G196S | grk-PA
G?S
Eggs derived from homozygous females dispay fused dorsal appendage that is narrower than a single appendage. Eggs derived from heterozygous mothers are completely wild type. brnfs.107/brn+; grkED22/grk+ females display large gaps in the follicular epithelium, frequently uncovering over half of the egg chamber exposing the nurse cells. Eggs derived from these females display dorsal appendages fused at the base with two appendages apparent, indistinguishable from a weak brn eggshell phenotype (intermediate or strong ventralised phenotype).
Eggs produced by fs(1)K10LM00 grkED22 or fs(1)K101 grkED22 double mutant females are more ventralised than eggs produced by grkED22 single mutant females. Most double mutant eggs contain no or only a node of dorsal appendage material positioned on the dorsal midline, whereas grkED22 single mutant eggs have at least one dorsal appendage that usually extends anteriorly beyond the anterior tip of the egg.
Weak ventralization of embryos. Filzkorper are normal. Only one dorsal appendage forms. 51% of laid eggs contain embryos. Mesoderm is wider than usual and cannot be enveloped by remaining epidermis. Two ventral furrows form.
grkED22 has dorsal appendage phenotype, non-enhanceable by LnkCR642
grkED22 has dorsal appendage phenotype, non-suppressible by LnkCR642
Weak mutation.