FlyBase Allele Report: Dmel\Lnk[CR642]

General Information

Symbol

Dmel\Lnk^CR642

Species

D. melanogaster

Name

FlyBase ID

FBal0268459

Feature type

allele

Associated gene

Dmel\Lnk

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Ferguson et al., 2012)

Mutagen

ethyl methanesulfonate

(Ferguson et al., 2012)

Progenitor genotype

Cytology

Description

Amino acid replacement: W298term.

(Ferguson et al., 2012)

Nucleotide substitution: G894A.

(Ferguson et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:25,891,110..25,891,110 [+]

Nucleotide change:

G25891110A

Reported nucleotide change:

G894A

Amino acid change:

Reported amino acid change:

W298term

Comment:

TGG to TGA nonsense mutation in the Trp298 codon.

(Ferguson et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The ovaries of homozygous females are morphologically normal. The rate of oogenesis is slower in homozygous ovaries compared to wild type. Eggs laid by homozygous females are patterned normally, but 18% do not hatch.

(Ferguson et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Lnk^CR642 is a non-enhancer of dorsal appendage phenotype of grk^ED22

(Ferguson et al., 2012)

Suppressor of

Statement

Reference

Lnk^f05062/Lnk^CR642 is a suppressor of dorsal appendage | maternal effect phenotype of spn-B^BU/spn-B^Δ37C

(Ferguson et al., 2012)

Lnk^d07478/Lnk^CR642 is a suppressor of dorsal appendage | maternal effect phenotype of spn-A^093A/spn-A¹

(Ferguson et al., 2012)

Lnk^CR642 is a suppressor of dorsal appendage | maternal effect phenotype of spn-B^BU

(Ferguson et al., 2012)

Lnk^CR642/Df(3R)Espl3 is a suppressor of dorsal appendage | maternal effect phenotype of spn-B^BU

(Ferguson et al., 2012)

Df(3R)BSC140/Lnk^CR642 is a suppressor of dorsal appendage | maternal effect phenotype of spn-B^BU

(Ferguson et al., 2012)

Lnk^d07478/Lnk^CR642 is a suppressor of dorsal appendage | maternal effect phenotype of spn-B^BU

(Ferguson et al., 2012)

NOT Suppressor of

Statement

Reference

Lnk^CR642 is a non-suppressor of dorsal appendage phenotype of grk^ED22

(Ferguson et al., 2012)

Lnk^CR642 is a non-suppressor of karyosome phenotype of spn-B^BU

(Ferguson et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The ventralisation phenotype seen in eggs laid by spn-B^BU females is suppressed if the females are also mutant for Lnk^CR642, Lnk^CR642/Df(3R)Espl3, Lnk^CR642/Df(3R)BSC140 or Lnk^CR642/Lnk^d07478.

The ventralisation phenotype seen in eggs laid by spn-A^093A/spn-A¹ females is suppressed if the females are also mutant for Lnk^CR642/Lnk^d07478.

Eggs laid by Lnk^CR642 ; grk^ED22 females are indistinguishable from those laid by grk^ED22 single mutant females, and all have a single dorsal appendage.

The ventralisation phenotype seen in eggs laid by spn-B^BU/spn-B^Δ37C females is suppressed if the females are also mutant for Lnk^CR642/Lnk^f05062.

The failure of karyosome condensation which is seen in spn-B^BU oocytes is not suppressed by Lnk^CR642.

(Ferguson et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Lnk^CR642 is rescued by Lnk^+tSF10

(Ferguson et al., 2012)

Lnk^CR642 is rescued by Scer\GAL4^{VP16.nanos.UTR}/Lnk^UASp.cFa

(Ferguson et al., 2012)