FB2024_03 , released June 25, 2024
Allele: Dmel\hbΔ
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General Information
Symbol
Dmel\hbΔ
Species
D. melanogaster
Name
FlyBase ID
FBal0031463
Feature type
allele
Associated gene
Dmel\hb
Associated Insertion(s)
Carried in Construct
P{hbΔ}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Wharton and Struhl, 1991)
Progenitor genotype
Carried in construct
P{hbΔ}
Cytology
Description

Construct: Deletion of 145 bp region including the endogenous hb NREs.

(Wharton and Struhl, 1991)
Allele components
Component
Use(s)
Encoded product / tool
hb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from females expressing hbΔ do not form abdominal segments.

      (Chen et al., 2008)

      Developing embryos lack abdomens. The pole cells are not enclosed by gonadal mesoderm but do express the correct markers. ovoD1 females transplanted with hbΔ pole cells produce fertile progeny, the pole cells do condense into the gonad.

      (Kobayashi et al., 1996)

      hb protein is expressed uniformly in the posterior half: larvae lack abdominal segments. hb protein accumulates in the pole cells.

      (Wharton and Struhl, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      hbΔ, nanosbcd.3UTR has embryonic thorax | anterior phenotype, suppressible | maternal effect by bcdΔ

      (Simpson-Brose et al., 1994)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Rescues the residual anterior thoracic defect of embryos from nosbcd.3UTR mothers that have been largely rescued by two maternal copies of bcdΔ.

      (Simpson-Brose et al., 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      H(D)
      (Wharton and Struhl, 1991)
      hbΔ
      hdΔ
      (Simpson-Brose et al., 1994)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)