FB2024_03 , released June 25, 2024
Allele: Dmel\pumFC8
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General Information
Symbol
Dmel\pumFC8
Species
D. melanogaster
Name
FlyBase ID
FBal0032525
Feature type
allele
Associated gene
Dmel\pum
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Caused by aberration
    Tp(3;1)FC8
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygotes show no significant memory defects.

        (Dubnau et al., 2003)

        Pole cells of embryos derived from pumMsc/pumFC8 females transplanted into wild-type host embryos pass normally through the midgut epithelium into the haemocoel. However, none of the transplanted pole cells are incorporated into the gonads of the host embryos, and they remain in the haemocoel and gut lumen. The average number of pole cells per embryo is reduced compared to controls in embryos derived from pumMsc/pumFC8 females.

        (Asaoka-Taguchi et al., 1999)

        Embryos derived from pumMsc/pumFC8 embryos have no abdominal segments. This phenotype is fully rescued if the females carry pumnos.PB, and is largely rescued if the females carry pumΔ2'.nos or pumΔ5'.nos.

        (Wharton et al., 1998)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        NOT suppressed by
        Statement
        Reference

        pumMsc/pumFC8 has ovary phenotype, non-suppressible by cupunspecified

        (Verrotti and Wharton, 2000)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        cupunspecified has no effect on the oogenesis defects associated with pumFC8/pumMsc females.

        (Verrotti and Wharton, 2000)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        pummilord-1

        (Dubnau et al., 2003)
        Rescued by

        pumMsc/pumFC8 is rescued by pumnanos.PB

        (Wharton et al., 1998)
        Partially rescued by

        pumMsc/pumFC8 is partially rescued by pumΔ2'.C1365R

        (Sonoda and Wharton, 2001)

        pumMsc/pumFC8 is partially rescued by pumΔ5'.nanos

        (Wharton et al., 1998)

        pumMsc/pumFC8 is partially rescued by pumΔ2'.nanos

        (Wharton et al., 1998)
        Not rescued by

        pumMsc/pumFC8 is not rescued by pumΔ2'.T1366D

        (Sonoda and Wharton, 2001)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        FC8
        (Tadros et al., 2007)
        pumFC8
        (Flora et al., 2018, Wharton et al., 2018)
        Name Synonyms
        Secondary FlyBase IDs
          References (13)