FlyBase Allele Report: Dmel\fng[D4]

General Information

Symbol

Dmel\fng^D4

Species

D. melanogaster

Name

FlyBase ID

FBal0034619

Feature type

allele

Associated gene

Dmel\fng

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

gain of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

gain of function allele

(Irvine and Wieschaus, 1994)

Mutagen

Delta2-3 transposase

(Irvine and Wieschaus, 1994)

Progenitor genotype

fng¹

(Irvine and Wieschaus, 1994)

Cytology

Description

At least some sequences from the fng¹ insert are still present.

(Irvine and Wieschaus, 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant

(Dansereau et al., 2002, de Celis and Bray, 2000, Irvine and Wieschaus, 1994)

Phenotype Manifest In

egg chamber

(Zhao et al., 2000)

follicle cell

(Zhao et al., 2000)

wing

(Dansereau et al., 2002, de Celis and Bray, 2000, Irvine and Wieschaus, 1994)

wing margin

(Dansereau et al., 2002)

Detailed Description

Statement

Reference

Heterozygotes lack most of the wing margin and much of the wing blade.

(Dansereau et al., 2002)

Compound egg chambers and a multilayered organisation of follicle cells are seen in mutant ovaries at stage 7-8, at a low frequency (approximately 2%).

(Zhao et al., 2000)

Heterozygous flies show scalloping of the wing.

(de Celis and Bray, 2000)

Loss of normal wing margin, and a significant reduction in wing size.

(Irvine and Wieschaus, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

fng^D4 has visible | dominant phenotype, suppressible by heph[+]/heph⁰³⁴²⁹

(Dansereau et al., 2002)

fng^D4 has visible | dominant phenotype, suppressible by N^Ax-1/N[+]

(Dansereau et al., 2002)

fng^D4 has visible | dominant phenotype, suppressible by N^Ax-M1

(de Celis and Bray, 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

fng^D4 has wing margin phenotype, suppressible by N^Ax-1/N[+]

(Dansereau et al., 2002)

fng^D4 has wing margin phenotype, suppressible by heph[+]/heph⁰³⁴²⁹

(Dansereau et al., 2002)

fng^D4 has wing phenotype, suppressible by heph[+]/heph⁰³⁴²⁹

(Dansereau et al., 2002)

fng^D4 has wing phenotype, suppressible by N^Ax-M1

(de Celis and Bray, 2000)

Other

Statement

Reference

Delta^UAS.cDa, Scer\GAL4^ptc-559.1, fng^D4 has wing | ventral phenotype

(Panin et al., 1997)

Scer\GAL4^ptc-559.1, Ser^UAS.cSa, fng^D4 has wing | ventral phenotype

(Panin et al., 1997)

Delta^UAS.cDa, Scer\GAL4^ptc-559.1, fng^D4 has wing phenotype

(Panin et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The loss of wing margin and wing blade seen in fng^D4/+ flies is partially rescued by heph⁰³⁴²⁹. The loss of wing margin seen in fng^D4/+ flies is partially rescued by N^Ax-1.

(Dansereau et al., 2002)

The wing scalloping phenotype of fng^D4 heterozygotes is suppressed by N^Ax-M1.

(de Celis and Bray, 2000)

Ectopic wing margin is formed in both dorsal and ventral cells of the wing when Dl^Scer\UAS.cDa is expressed using Scer\GAL4^ptc-559.1 in a fng^D4 background.

(Panin et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mutant phenotype parallels that observed for fng^- wing clones.

(Irvine and Wieschaus, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fng^D4

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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