Deletion within the 5' untranslated region.
The rough boundaries of the P excision mutation were mapped to a restriction fragment. The deletion takes out 5' noncoding and some coding sequence of chic. The position of the restriction fragment on the reference sequence was inferred by a FlyBase curator.
aster & meiotic cell cycle | male
Homozygous adults have abnormal bristles. Onion-stage spermatids usually contain a single Nebenkern of larger than normal size, associated with two or more normal-sized nuclei (65.4% of spermatids have 4 nuclei). Onion-stage spermatids of chic37/chicR1 males usually contain a single Nebenkern of larger than normal size, associated with two or more normal-sized nuclei (67.6% of spermatids have 4 nuclei). 87% of asters show irregular positioning and delayed migration during meiotic divisions in chic37/chicR1 males.
Homozygous males exhibit altered cyst cell behaviour. Male germ cells are rare and these germ cells fail to proliferate properly.
Homozygotes show dramatic defects in the proliferation of the male and female germline. The germarium is devoid of germline material, resulting in empty follicle stacks. A few egg chambers do develop but are resorbed into the abdomen as the females age. Follicle cell stacks are elongated. Testes from mutant males show a similar defect in that they become agametic. Microchaetae and macrochaetae bristles on the head, thorax, legs and wings are affected to various degrees. Mutant bristles are thicker and shorter than wild type, with bends, kinks and forked ends. Their ridges are thinner, more numerous and disorganized.
chic[+]/chic37 is a suppressor | partially of abnormal developmental rate phenotype of cpbF19/cpb6.15
chic[+]/chic37 is a suppressor | partially of partially lethal - majority die phenotype of cpbF19/cpb6.15
