FB2024_03 , released June 25, 2024
Allele: Dmel\dia3
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General Information
Symbol
Dmel\dia3
Species
D. melanogaster
Name
FlyBase ID
FBal0039244
Feature type
allele
Associated gene
Dmel\dia
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Castrillon and Wasserman, 1994)
Mutagen
Delta2-3 transposase
(Castrillon and Wasserman, 1994)
Progenitor genotype
dia1
(Castrillon and Wasserman, 1994)
Cytology
Description

Deletion in 5'part of dia coding region.

(Castrillon and Wasserman, 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:20,755,758..20,761,488 [+]
Comment:

The approximate boundaries of the dia3 deletion map to a BamHI-XbaI restriction fragment; the position of the restriction fragment on the reference sequence was inferred by a FlyBase curator.

(Castrillon and Wasserman, 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      contractile ring & meiotic cell cycle | male

      (Giansanti et al., 1998)

      imaginal disc

      (Castrillon and Wasserman, 1994)

      larval central nervous system & neuroblast

      (Castrillon and Wasserman, 1994)

      spindle & meiotic cell cycle | male

      (Giansanti et al., 1998)
      Detailed Description
      Statement
      Reference

      The central spindle is severely defective in the first meiotic division in homozygous testes, and the actin ring is usually missing.

      (Giansanti et al., 1998)

      Early pupal lethality and reduced imaginal discs in third instar larvae. Larval neuroblasts show high levels of polyploidy and significantly fewer mitotic figures than wild type, however the fraction of mitotic figures in anaphase is the same as in wild type.

      (Castrillon and Wasserman, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      dia3 is rescued by dia+t11

      (Castrillon and Wasserman, 1994)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      One of 17 alleles isoalted in a reversion screen of dia1.

      (Castrillon and Wasserman, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dia3
      Name Synonyms
      Secondary FlyBase IDs
        References (2)