FB2024_03 , released June 25, 2024
Allele: Dmel\fl(2)d2
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General Information
Symbol
Dmel\fl(2)d2
Species
D. melanogaster
Name
FlyBase ID
FBal0039343
Feature type
allele
Associated gene
Dmel\fl(2)d
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Granadino et al., 1992, Granadino et al., 1990)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Granadino et al., 1992)
Description

Amino acid replacement: Q72term.

(Penalva et al., 2000)

Nucleotide substitution: C615T.

(Penalva et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:13,823,915..13,823,915 [-]
Nucleotide change:

C13823915T

Reported nucleotide change:

C615T|FBrf0127272

Amino acid change:

Q72term | fl(2)d-PA

Reported amino acid change:

Q72term

(Penalva et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fl(2)d2/+ suppresses position effect variegation at the w locus caused by P{SUPor-P}KV00108.

      (Swenson et al., 2016)

      Does not interact with Sxldlf, fl(1)3535, fl(1)3546 or l(1)4343.

      (Anand et al., 1998)

      fl(2)d1/fl(2)d2 heterozygotes are female lethal at 29oC and females have reduced viability at 18oC.

      (Hilfiker et al., 1994)

      Homozygotes die very early in larval development. fl(2)d1/fl(2)d2 females show temperature-sensitive lethality, and males show temperature-sensitive semi-lethality. The lethality of fl(2)d1/fl(2)d2 females but not homozygous females is partially suppressed by SxlM1. The semi-lethality of homozygous and fl(2)d1/fl(2)d2 males is independent of Sxl function. The lethality of SxlM1 males is partially suppressed in fl(2)d1/fl(2)d2 flies. Partially suppresses the female germline phenotype of ovoD1rv23 flies.

      (Granadino et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      fl(2)d2 is an enhancer of phenotype of Ubx9.22

      (Burnette et al., 1999)

      fl(2)d2 is an enhancer of phenotype of Ubx195

      (Burnette et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Df(2L)BSC209/+;fl(2)d2/+ double heterozygous females show significantly reduced viability compared to Df(2L)BSC209 single heterozygotes.

      (Knuckles et al., 2018)

      The female progeny of fl(2)d2/+ females mated to SxlfP7B0/Y males show only 87.4% viability.

      The female progeny of snfJ210/+ ; fl(2)d2/+ females mated to SxlfP7B0/Y males show only 74.4% viability.

      The female progeny of snf148/+ ; fl(2)d2/+ females mated to SxlfP7B0/Y males show only 45.6% viability.

      The female progeny of snfJ210/+ ; fl(2)d2/+ ; snf5MER females mated to SxlfP7B0/Y males show 79.3% viability.

      The female progeny of U2af38ΔE18/fl(2)d2 females mated to SxlfP7B0/Y males show only 90.1% viability.

      (Penn et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      fl(2)dP

      (Penalva et al., 2000)
      Rescued by

      fl(2)d2 is rescued by fl(2)dβTub56D.PP

      (Penalva et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      XX cells in fl(2)d2 homozygous clones follow the male developmental pathway in spite of their female chromosomal constitution.

      (Granadino et al., 1990)

      Clonal analysis suggests that fl(2)d2 is not a cell lethal mutation.

      (Granadino et al., 1991)

      Pole cell transplantation shows that homozygous fl(2)d2 germ cells cannot develop into functional oocytes, but can give rise to functional sperm.

      (Granadino et al., 1992)

      Homozygous larvae and heteroallelic larvae with fl(2)d1, reared at 25oC, have msl-1 and mle associated with numerous sites along the paired X chromosomes.

      (Hilfiker et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fl(2)d2
      (Anand et al., 1998)
      fl(2)d2
      (Knuckles et al., 2018, Swenson et al., 2016, Johnson et al., 2010, Penn et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (15)