FB2024_03 , released June 25, 2024
Allele: Dmel\Ubx9.22
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General Information
Symbol
Dmel\Ubx9.22
Species
D. melanogaster
Name
FlyBase ID
FBal0017483
Feature type
allele
Associated gene
Dmel\Ubx
Associated Insertion(s)
Carried in Construct
Also Known As
Ubx9-22, Ubx922
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Limbourg-Bouchon et al., 1991)
Mutagen
X ray
(Weinzierl et al., 1987, Bender et al., 1983, Capdevila and Garcia-Bellido, 1981)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Castelli-Gair and Garcia-Bellido, 1990, Bender et al., 1983, Kerridge and Morata, 1982)
Description

Deletion and associated frameshift producing a truncated protein that lacks the homeodomain and C-terminal sequences.

(Mastick et al., 1995)

Deletion of 1.6kb removing part of intron 3 and the common 3' exon up to and including the first 48 codons of the homeodomain. Inactivates all Ubx isoforms.

(Subramaniam et al., 1994)

Deletion of 16kb within the Ubx transcript.

(Limbourg-Bouchon et al., 1991)

Deletion in the homeobox.

(Castelli-Gair and Garcia-Bellido, 1990)

1.5kb deletion including the homeobox.

(Castelli-Gair et al., 1990)

Deletion in the Ubx coding region.

(Mathog, 1990)

1587bp deletion removing the final 1.4kb of the 50kb long intron, the splice acceptor site of the 3' exon and 48 codons of the homeobox. A sequence of 6 nucleotides is inserted between the deletion breakpoints.

(Weinzierl et al., 1987)

Deletion in the 3' Ubx exon.

(Peifer and Bender, 1986)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:16,658,918..16,660,498 [-]
Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author's statement. See Figure 2 of FBrf0046283. Mutation is a deletion of 1580bp which removes the splice acceptor site and much of the homeobox.

(Weinzierl et al., 1987)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
X05727
CAA29194
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ubx1/Ubx9.22 transheterozygous embryos show a significant increase in the proportion of mitotic neuroblast daughter cells, but not mitotic neuroblasts, only in the A1 ventral nerve cord segment, as compared to controls.

      (Monedero Cobeta et al., 2017)

      The anterior pair of Malpighian tubules do not migrate past the developing midgut in Ubx9.22 mutant embryos.

      (Bunt et al., 2010)

      Homozygous Ubx9.22 mutant embryos fail to develop the 2-3 most anterior pairs of alary muscles.

      (LaBeau et al., 2009)

      Ubx9.22 clones within the haltere do not grow larger than their twin spots.

      The P compartment of Ubxpbx-1/Ubx9.22 haltere discs is increased in size relative to the disc, such that the P:A size ration is 1.45. This effect is not seen in Ubx9.22/+ discs.

      (Crickmore and Mann, 2006)

      In stage-15 Ubx9.22 mutant embryos the lymph gland is expanded posteriorly into the abdominal segments.

      (Mandal et al., 2004)

      Homozygous embryos frequently show a range of defects in dorsal vessel development, including incomplete dorsal migration of the cardiac precursors and minor morphological defects of the dorsal vessel, but there is still a clear distinction between the heart and the aorta in these animals.

      (Lovato et al., 2002)

      The aorta does not differentiate normally, particularly in the anterior region, in mutant embryos. Pericardiac cells are also disorganised in several positions, particularly in the anterior segments.

      (Ponzielli et al., 2002)

      When heterozygous with UbxHC71-1.HC166D.Dup.Rec.ry+ the notum reduction phenotype is much more penetrant and severe. These animals also show an enlargement of the haltere, with anterior bristles, characteristic of a weak bx transformation.

      (Bender and Hudson, 2000)

      Haltere enlarged, average bristle number 0.9 (+-0.9 (SD); N=138).

      (Burnette et al., 1999)

      No gross morphological defects are seen in the central nervous system of Ubx9.22 Abd-BM1 double mutant embryos.

      (Hirth et al., 1998)

      Embryos lack the precursor for ventral muscle 26 in A1 and A2.

      (Michelson, 1994)

      Transformation of capitellum to wing.

      (Mortin et al., 1992)

      Elevated levels of ae transcript are found in parasegment 6.

      (Roder et al., 1992)

      Homozygous embryos have a set of extra leg discs, a rudimentary wing disc and two new sets of spiracles.

      (Bate and Martinez Arias, 1991)

      The phenotype of fu41 Ubx9.22 double mutants can be interpreted as an addition of the corresponding single mutant phenotypes.

      (Limbourg-Bouchon et al., 1991)

      Does not affect the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.

      (Castelli-Gair and Garcia-Bellido, 1990)

      Transvection positive with Ubxbx-34e.

      (Mathog, 1990)

      A2-A4 denticle belts are transformed into thoracic belts, and A5-A8 denticle belts are modified, having much more marked thoracic features in hemizygous embryos.

      (Casanova et al., 1988)

      Homozygotes complete embryogenesis and occasionally survive as third instar larvae. They have the characteristic Ubx phenotype of transformed denticle belts and three pairs of anterior spiracles. In Ubx61d/Ubxbxd-100 larvae A1 is transformed to T3, and a pair of presumptive leg neuromeres is formed in this transformed segment. In Ubx9.22/Ubxbxd-100 adults the commissures of the CNS in parasegment 6 are transformed to resemble those of parasegment 5.

      (Weinzierl et al., 1987)

      The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is not increased in flies also heterozygous for Ubx9.22.

      (Capdevila and Garcia-Bellido, 1981)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Ubx9.22 has visible phenotype, enhanceable by Df(2L)PJ17

      (Bai and Tolias, 2000)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Ubx9.22 has haltere phenotype, enhanceable by Df(2L)PJ17

      (Bai and Tolias, 2000)

      Ubx9.22 has macrochaeta | ectopic phenotype, enhanceable by Df(2L)PJ17

      (Bai and Tolias, 2000)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(2L)PJ17

      (Bai and Tolias, 2000)

      Ubx9.22 has phenotype, enhanceable by fl(2)d2

      (Burnette et al., 1999)

      Ubx9.22 has phenotype, enhanceable by vir3

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(1)KA14

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(1)C246

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(1)sd72b

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(1)N19

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(1)HF396

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(2L)dp-79b

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(2L)TE29Aa-11

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(2L)Mdh

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(2L)Prl

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(2L)TW203

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by crn3

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(2L)TW158

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(2L)TW84

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3L)pbl-X1

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3L)pbl-NR

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3L)Rdl-2

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3L)29A6

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3L)fz-D21

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3L)fz-M21

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3L)brm11

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3L)st-f13

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by crn4

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3L)ri-79c

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)ME15

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)9A99

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)Antp17

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)by10

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)by62

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)M-Kx1

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)M86D

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)Delta-BX12

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)crb87-4

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by kz26

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)crb87-5

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)X3F

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)awd-KRB

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(4)G

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)l26c

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(3R)ry506-85C

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Hrb27C[+]/Hrb27C10280

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(1)64c18

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(1)JC19

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(1)dm75e19

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(1)HC244

      (Burnette et al., 1999)

      Ubx9.22 has haltere sensillum phenotype, enhanceable by Df(1)Sxl-bt

      (Burnette et al., 1999)
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of tkvScer\UAS.cNa under the control of Scer\GAL4Act5C in a Ubxpbx-1/Ubx9.22 background reduces the size of the P compartment of haltere discs relative to that observed in Ubxpbx-1/Ubx9.22 discs (from 1.45 to 0.83), although this ratio is still greater than that of wild-type discs.

      (Crickmore and Mann, 2006)

      The addition of Df(2L)PJ17 to Ubx9.22 flies enhances the haltere bristle phenotype seen in Ubx9.22 alone. An average of 3.5 bristles per haltere are seen in Df(2L)PJ17,Ubx9.22 flies, as opposed to none in wild-type and 0.9 per haltere in Ubx9.22 flies alone.

      (Bai and Tolias, 2000)

      Hrb27C10280 enhances the haltere phenotype of Ubx9.22/+ such that halteres are enlarged, and average bristle number 2.6 (+-1.5 (SD); N=46).

      (Burnette et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (7)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Ubx9.22 homozygous germ line clones are viable and show no maternal effects.

      (Kerridge and Dura, 1982)
      External Crossreferences and Linkouts ( 2 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      Synonyms and Secondary IDs (4)
      References (57)