FlyBase Allele Report: Dmel\vir[3]

General Information

Symbol

Dmel\vir³

Species

D. melanogaster

Name

FlyBase ID

FBal0040112

Feature type

allele

Associated gene

Dmel\vir

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Hilfiker et al., 1995)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased fecundity | female

(Schutt et al., 1998)

lethal

(Hilfiker et al., 1994)

lethal | maternal effect | recessive

(Schutt et al., 1998)

lethal | recessive

(Burnette et al., 1999)

lethal - all die before end of larval stage | female

(Hilfiker et al., 1995)

some die during larval stage | female

(Hilfiker et al., 1995)

Phenotype Manifest In

Detailed Description

Statement

Reference

Female germ cells homozygous for vir³ can complete oogenesis. Females carrying these homozygous germ line clones produce eggs (although fecundity is reduced) but when mated to vir⁺ males no larvae hatch (except for a few escapers). These phenotypes are rescued if the homozygous germ line clones are induced in females carrying vir^+t10. The developmental potential of vir³/+ embryos derived from females carrying homozygous vir³ germ line clones and vir⁺ males is variable; some arrest at the blastoderm stage, others die as differentiated embryos or, rarely, as larvae. Whole larval gonads of the genotype XY ; vir³/Df(2R)vir130 form sperm after they are transplanted into the abdomen of adult females. Fertile males with integrated vir³/Df(2R)vir130 pole cells can be produced when XY ; vir³/Df(2R)vir130 pole cells are transplanted into agametic XY embryos.

(Schutt et al., 1998)

Male homozygotes and male transheterozygotes with other EMS induced vir mutations die during larval or pupal stage, very few male escapers are present. Transheterozygotes with vir^ts transform XX animals into intersexes at 29^oC. Homozygous clones that occur in the sexually dimorphic regions of females differentiate male structures. Clones in males produce normal male structures. Sxl⁺/Sxl⁺;vir³/vir^ts and Sxl^f1/Sxl⁺;vir³/vir⁺ are viable but doubly heterozygous Sxl^f1/Sxl⁺;vir³/vir^ts females are lethal.

(Hilfiker et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

vir^unspecified/vir³ has lethal | female | larval stage phenotype, non-suppressible by Sxl^F1.hs

(Hilfiker et al., 1995)

vir^unspecified/vir³ has lethal | female | larval stage phenotype, non-suppressible by Sxl^M1

(Hilfiker et al., 1995)

vir^unspecified/vir³ has lethal | female | larval stage phenotype, non-suppressible by Sxl^M4

(Hilfiker et al., 1995)

vir³ has lethal | female | larval stage phenotype, non-suppressible by msl-1^γ222

(Hilfiker et al., 1995)

vir³ has lethal | female | larval stage phenotype, non-suppressible by msl-2^γ136

(Hilfiker et al., 1995)

vir³ has lethal | female | larval stage phenotype, non-suppressible by mle⁹

(Hilfiker et al., 1995)

Phenotype Manifest In

Enhancer of

Statement

Reference

vir³ is an enhancer of phenotype of Ubx^9.22

(Burnette et al., 1999)

vir³ is an enhancer of phenotype of Ubx¹⁹⁵

(Burnette et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The phenotype seen in females carrying homozygous germ line clones is not rescued if the germ line cells also carry Sxl^M1 or Sxl^M4.

(Schutt et al., 1998)

Female lethality cannot be rescued by msl-1^γ222, msl-2^γ136 or mle⁹ mutations. The presence of Sxl^M1, Sxl^M4 or Sxl^F1.hs failed to rescue female lethality in vir transheterozygotes.

(Hilfiker et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

vir³ is rescued by vir^+t10

(Schutt et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Homozygous larvae and heteroallelic larvae with vir^2f, reared at 25^oC, have msl-1 and mle associated with numerous sites along the paired X chromosomes.

(Hilfiker et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

vir³

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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