FlyBase Allele Report: Dmel\msl-2[γ136]

General Information

Symbol

Dmel\msl-2^γ136

Species

D. melanogaster

Name

FlyBase ID

FBal0044190

Feature type

allele

Associated gene

Dmel\msl-2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: V?C.

(Zhou et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:3,465,511..3,465,513 [-]

Comment:

3bp deletion resulting in a deletion of a valine residue (amino acid 42) between the first and second cysteines in the RING finger domain.

(Zhou et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | male

(Zhou et al., 1995)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

msl-2^γ136 is a suppressor of lethal | female | larval stage phenotype of vir^2f

(Hilfiker et al., 1995)

NOT Suppressor of

Statement

Reference

msl-2^γ136 is a non-suppressor of lethal | female | larval stage phenotype of vir³

(Hilfiker et al., 1995)

msl-2^γ136 is a non-suppressor of lethal | female | larval stage phenotype of vir⁴

(Hilfiker et al., 1995)

msl-2^γ136 is a non-suppressor of lethal | female | larval stage phenotype of vir⁵

(Hilfiker et al., 1995)

msl-2^γ136 is a non-suppressor of lethal | female | larval stage phenotype of vir⁶

(Hilfiker et al., 1995)

msl-2^γ136 is a non-suppressor of lethal | female | larval stage phenotype of vir⁷

(Hilfiker et al., 1995)

msl-2^γ136 is a non-suppressor of lethal | female phenotype of vir^unspecified

(Hilfiker et al., 1995)

Phenotype Manifest In

Enhancer of

Statement

Reference

msl-2^γ136 is an enhancer of phenotype of msl-1^{Δ84.Tag:FLAG}

(Scott et al., 2000)

NOT Enhancer of

Statement

Reference

msl-2^γ136 is a non-enhancer of phenotype of msl-1^{C.hs.Tag:FLAG}

(Scott et al., 2000)

NOT Suppressor of

Statement

Reference

msl-2^γ136 is a non-suppressor of phenotype of msl-1^{C.hs.Tag:FLAG}

(Scott et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of msl-2^γ136 to flies containing a single copy of msl-1^{Δ84.T:Zzzz\FLAG} in weak heatshock conditions enhances the male viability phenotype seen in these flies. The addition of msl-2^γ136 to flies containing a single copy of msl-1^{C.hs.T:Zzzz\FLAG} in weak heatshock conditions has no effect on the male viability phenotype seen in these flies.

(Scott et al., 2000)

Female lethality of EMS induced vir mutations cannot be rescued by the msl-2^γ136 mutation.

(Hilfiker et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

msl-2^γ136

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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