FlyBase Allele Report: Dmel\kni[unspecified]

General Information

Symbol

Dmel\kni^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0039450

Feature type

allele

Associated gene

Dmel\kni

Associated Insertion(s)

Carried in Construct

Also Known As

unspecified

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Moore et al., 1998)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | gap | recessive

(Tearle and Nusslein-Volhard, 1987)

some die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

Phenotype Manifest In

embryo | gap

(Moore et al., 1998)

embryonic/first instar larval cuticle & abdominal segment 1

(Tearle and Nusslein-Volhard, 1987)

embryonic/first instar larval cuticle & abdominal segment 2

(Tearle and Nusslein-Volhard, 1987)

embryonic/first instar larval cuticle & abdominal segment 3

(Tearle and Nusslein-Volhard, 1987)

embryonic/first instar larval cuticle & abdominal segment 4

(Tearle and Nusslein-Volhard, 1987)

embryonic/first instar larval cuticle & abdominal segment 5

(Tearle and Nusslein-Volhard, 1987)

embryonic/first instar larval cuticle & abdominal segment 6

(Tearle and Nusslein-Volhard, 1987)

embryonic/first instar larval cuticle & abdominal segment 7

(Tearle and Nusslein-Volhard, 1987)

embryonic/larval plasmatocyte

(Tepass et al., 1994)

Detailed Description

Statement

Reference

Embryos exhibit gap defects.

(Moore et al., 1998)

Cell death is dramatically increased in the mutant embryo, most cells in the kni expression domain die. Although no extra mesoderm cells are induced to become hemocytes the macrophages become larger than average. Cellular debris becomes located extracellularly in the hemolymph.

(Tepass et al., 1994)

Segments A1 to A7 are fused into a single denticle belt in kni^unspecified mutant embryos.

(Tearle and Nusslein-Volhard, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

kni^unspecified has lethal phenotype, suppressible by Res¹

(Ruden and Jäckle, 1994)

Phenotype Manifest In

Suppressed by

Statement

Reference

kni^unspecified has phenotype, suppressible by neb^TE2

(Ruden et al., 1997)

kni^unspecified has phenotype, suppressible by neb^TE8

(Ruden et al., 1997)

kni^unspecified has phenotype, suppressible by neb^k02406

(Ruden et al., 1997)

kni^unspecified has phenotype, suppressible by neb^k05702

(Ruden et al., 1997)

kni^unspecified has phenotype, suppressible by God60D¹

(Ruden et al., 1997)

kni^unspecified has phenotype, suppressible by neb⁰¹³⁰⁰

(Ruden et al., 1997)

kni^unspecified has phenotype, suppressible by neb⁰³⁵⁵²

(Ruden et al., 1997)

kni^unspecified has phenotype, suppressible by neb⁰⁵²¹⁷

(Ruden et al., 1997)

kni^unspecified has phenotype, suppressible by neb^Mot

(Ruden et al., 1997)

kni^unspecified has phenotype, suppressible by neb^TE12

(Ruden et al., 1997)

kni^unspecified has phenotype, suppressible by neb^TE20

(Ruden et al., 1997)

kni^unspecified has phenotype, suppressible by Egfr^E3/Egfr[+]

(Diaz-Benjumea and Garcia-Bellido, 1990)

Enhancer of

Statement

Reference

kni^unspecified is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, nej^ΔBHQ.UAS

(Anderson et al., 2005)

kni^unspecified is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, nej^ΔNZK.UAS

(Anderson et al., 2005)

Suppressor of

Statement

Reference

kni^unspecified/kni^unspecified is a suppressor of phenotype of Egfr^E3

(Diaz-Benjumea and Garcia-Bellido, 1990)

Other

Statement

Reference

gt^unspecified, kni^unspecified, tll^unspecified has epidermis phenotype

(Bronner and Jäckle, 1991)

kni^unspecified, tll^unspecified has epidermis phenotype

(Bronner and Jäckle, 1991)

Additional Comments

Genetic Interactions

Statement

Reference

The terminal regions of kni^unspecified tll^unspecified double mutants develop a single large denticle band. Triple mutant kni^unspecified gt^unspecified tll^unspecified embryos develop a lawn of denticles which extends from the terminal into the abdominal region of the embryo.

(Bronner and Jäckle, 1991)

kni^unspecified/kni^unspecified Egfr^t1/Egfr^f11 double homozygotes show a simple additive phenotype. Egfr^E3/+ shows a negative interaction in combination with kni^unspecified/kni^unspecified.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

kni^unspecified is rescued by kni^tRa

(Pankratz et al., 1992)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

5 mutants are isolated.

(Moore et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

kni^unspecified

unspecified

(Bronner and Jäckle, 1991, Diaz-Benjumea and Garcia-Bellido, 1990)

Name Synonyms

Secondary FlyBase IDs

FBal0056265

References (11)

Report Sections

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