FlyBase Allele Report: Dmel\Delta[unspecified]

General Information

Symbol

Dmel\Delta^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0042507

Feature type

allele

Associated gene

Dmel\Delta

Associated Insertion(s)

Carried in Construct

Also Known As

unspecified

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

X ray

(Prout et al., 1997)

ethyl methanesulfonate

(Moore et al., 1998)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Park et al., 2011)

lethal - all die during embryonic stage | recessive

(Prout et al., 1997, Tearle and Nusslein-Volhard, 1987)

some die during embryonic stage | recessive

(Prout et al., 1997, Tearle and Nusslein-Volhard, 1987)

visible | dominant

(Tearle and Nusslein-Volhard, 1987)

visible | somatic clone

(Prout et al., 1997)

Phenotype Manifest In

Detailed Description

Statement

Reference

The number of corpora cardiaca cells is increased in mutant late stage 17 embryos (110.2 +/- 23.7 cells) compared to wild type (14.0 +/- 0.8 cells). The number of insulin producing cells is reduced in the mutant stage 17 embryos (2.3 +/- 1.7 cells) compared to wild type (12.5 +/- 2.5).

(Park et al., 2011)

When single cell somatic clones are made in the eye, ommatidia with too many or too few neural cells can be seen. Occasionally ommatidia containing one or more mutant cells differentiate eight photoreceptor cells in the normal arrangement. In these cases each of the R1-R7 photoreceptor cells is able to contribute to a normally constructed ommatidium without Dl. Loss of Dl from R3 leads to an exchange of R3 and R4 fates and chiral reversal, and simultaneous loss of Dl from R1 and R6 leads to R7 adopt a R1/6-like morphology. Mutant R2 and R5 cells are rarely seen, mutant R8 cells are never seen.

(Li et al., 2003)

Boundary cell differentiation in the hindgut is suppressed in mutant embryos.

(Takashima et al., 2002)

Mutants show an increased number of tendon cells at late stages of embryonic development (after muscle binding has occurred) compared to wild type.

(Nabel-Rosen et al., 1999)

Embryos have extra eve-positive mesodermal cells compared to wild-type. No eve-positive mesodermal cells develop in wg^unspecified; Dl^unspecified double mutants, as in wg^unspecified single mutants.

(Carmena et al., 1998)

Embryos exhibit a neurogenic phenotype.

(Moore et al., 1998)

Homozygous clones in the wing produce discrete, round blisters of variable size. These blisters can be located anywhere on the wing and are associated with abnormalities in venation. Homozygous clones that include the wing margin cause scalloping due to cell death.

(Prout et al., 1997)

Embryos lacking Dl function, or maternal and zygotic N function, fail to develop principal midgut epithelial cells and no midgut epithelium develops.

(Tepass and Hartenstein, 1995)

Homozygous embryos lack ventral cuticle and show hypertrophy of the ventral nervous system. Heterozygotes show thickening of the wing veins.

(Tearle and Nusslein-Volhard, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Delta^unspecified/Dl[+] is an enhancer of visible | recessive phenotype of mys^b9

(Prout et al., 1997)

Other

Statement

Reference

Delta^unspecified, N^Mcd5 has visible | somatic clone phenotype

(Ramain et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

Delta^unspecified has phenotype, enhanceable by M285^M285

(Go and Artavanis-Tsakonas, 1998)

Delta^unspecified has wing vein phenotype, enhanceable by RpL9¹

(Schmidt et al., 1996)

Delta^unspecified has phenotype, enhanceable by E(nd)195^ry+3550

(Hing and Artavanis-Tsakonas, 1995)

Suppressed by

Statement

Reference

Delta^unspecified has phenotype, suppressible by emc^D

(Mari-Beffa et al., 1991)

Enhancer of

Statement

Reference

Delta^unspecified is an enhancer of phenotype of mys⁸

(Prout et al., 1997)

Suppressor of

Statement

Reference

Delta^unspecified is a suppressor of phenotype of emc^D

(Mari-Beffa et al., 1991)

Other

Statement

Reference

Delta^unspecified, ed^4.12 has trichogen cell | ectopic phenotype

(Rawlins et al., 2003)

Delta^unspecified, N^Mcd5 has microchaeta | somatic clone phenotype

(Ramain et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

N^Mcd5 Dl^unspecified double mutant clones do not develop microchaetae but produce epidermis.

(Ramain et al., 2001)

Shows a weak genetic interaction with mys⁸ and mys^b9.

(Prout et al., 1997)

emc^D shows mutual rescuing with Dl^unspecified.

(Mari-Beffa et al., 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Delta^EP3816.A

(Alexander et al., 2006)

Rescued by

Delta^unspecified is rescued by Delta^T4b24c

(Bender et al., 1993)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

4 mutants are isolated.

(Moore et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Delta^unspecified

Dl^unspecified

unspecified

(Prout et al., 1997, Johnson et al., 1995, Tepass and Hartenstein, 1995)

Name Synonyms

Secondary FlyBase IDs

References (25)

Report Sections

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