FB2024_03 , released June 25, 2024
Allele: Dmel\chnk04218
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General Information
Symbol
Dmel\chnk04218
Species
D. melanogaster
Name
FlyBase ID
FBal0042907
Feature type
allele
Associated gene
Dmel\chn
Associated Insertion(s)
P{lacW}chnk04218
Carried in Construct
Also Known As
l(2)k04218
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Kania et al., 1995)
Progenitor genotype
Associated Insertion(s)
P{lacW}chnk04218
Cytology
Description

Insertion at position -152 relative to the chn transcription start site.

(Escudero et al., 2005)

Insertion of a P{lacW} element.

(Kania et al., 1995)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      chnk04218 homozygous mutant clones in the eye have normal morphology at 1 day old and then show retinal degeneration, and ERG recordings show a small response.

      (Huang et al., 2015)

      Homozygous embryos exhibit neurons that are slightly larger than wild type and the lateral chordotonal (Lch) neurons are bunched.

      (Kania et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      chn[+]/chnk04218 is a non-enhancer of visible | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      NOT Suppressor of
      Statement
      Reference

      chn[+]/chnk04218 is a non-suppressor of visible | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      chn[+]/chnk04218 is a non-enhancer of eye | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      NOT Suppressor of
      Statement
      Reference

      chn[+]/chnk04218 is a non-suppressor of eye | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      chn02064

      (BDGP Project Members, 1994-1999)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      I. Kiss.

      Comments
      Comments

      P{lacW} insertion can be excised and revert the lethal phenotype to wild type.

      (Kania et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      42/18
      (Kania et al., 1995)
      chn42/18
      (Escudero et al., 2005)
      chnk04218
      (Huang et al., 2015)
      l(2)k04218
      (Dworak et al., 2001, Spradling et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)