FlyBase Allele Report: Dmel\gl[+t9954]

General Information

Symbol

Dmel\gl^+t9954

Species

D. melanogaster

Name

FlyBase ID

FBal0043096

Feature type

allele

Associated gene

Dmel\gl

Associated Insertion(s)

Carried in Construct

P{gl(10kbSal)}

Key Links

Genomic Maps

JBrowse

Transgenic product class

genomic_DNA

(Moses et al., 1989)

wild_type

(Moses et al., 1989)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Moses et al., 1989)

wild_type

(Moses et al., 1989)

Mutagen

in vitro construct

(Liu et al., 1996, Mukhopadhyay and Campos, 1995, Moses et al., 1989)

Progenitor genotype

Carried in construct

P{gl(10kbSal)}

Cytology

Description

9954bp gl genomic fragment including 4188bp 5' to the transcription start site and 933bp 3' to the poly-adenylation site.

(Liu et al., 1996)

9,954bp SalI fragment of gl that contains all sequences necessary for gene function.

(Moses et al., 1989)

Allele components

Component

Use(s)

Regulatory region(s)

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

rescue_region

3R:18,366,966..18,376,901 [-]

Linked to:

SalI-SalI restriction fragment

Comment:

Position of restriction fragment on reference sequence inferred by FlyBase curator.

(Liu et al., 1996, Mukhopadhyay and Campos, 1995, Sawin-McCormack et al., 1995, Moses et al., 1989)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Busto et al., 1999, Ma et al., 1996, Sawin-McCormack et al., 1995, Moses et al., 1989)

Phenotype Manifest In

retina & fascicle | somatic clone

(Kunes et al., 1993)

Detailed Description

Statement

Reference

Retinal axon projection defects are found in clones covering the entire eye. Mosaics exhibiting loss of the optic nerve, but gl⁺ photoreceptors, do not show aberrant retinal projections suggesting the larval optic nerve is not required as a pioneer in retinal axon guidance. Clones of gl^- cells surrounded by wild type cells in the eye demonstrate wild type retinal fascicles are found in approximately correct dorsoventral positions despite the aberrant behaviour of their mutant neighbours.

(Kunes et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions