FlyBase Allele Report: Dmel\shn[04738]

(Chung et al., 2001, Dai et al., 2000, Takatsu et al., 2000, Xie and Spradling, 2000, Spradling et al., 1999, Russell et al., 1998, Arora et al., 1995, Staehling-Hampton et al., 1995, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999)

lethal - all die during embryonic stage

(Arora et al., 1995, Grieder et al., 1995)

lethal - all die during embryonic stage | recessive

(Russell et al., 1998, Perrimon et al., 1996)

some die during embryonic stage

(Arora et al., 1995, Grieder et al., 1995)

some die during embryonic stage | recessive

(Russell et al., 1998, Perrimon et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant embryos show a 'dorsal open' cuticle phenotype.

(Yao et al., 2006)

Mutant embryos show a "dorsal open" phenotype due to a loss of dorsal cell fates and are partially ventralised. The Filzkorper are reduced.

(Torres-Vazquez et al., 2001)

Clonal analysis in the germarium shows that shn⁰⁴⁷³⁸ mutant stem cells are lost at an increased rate and replaced by wild-type cells.

(Xie and Spradling, 2000)

Homozygous embryos lack dorsal hypoderm.

(Russell et al., 1998)

Homozygous embryos lack the dorsal hypoderm.

(Perrimon et al., 1996)

Dorsal closure fails, dorsal epidermis is significantly reduced. Denticles on the lateral region are abnormally oriented and disrupted.

(Arora et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

shn⁰⁴⁷³⁸/shn[+] is an enhancer of visible | dominant phenotype of Bx¹

(Bejarano et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

shn⁰⁴⁷³⁸ has embryonic dorsal epidermis phenotype, suppressible by Hsap\HIVEP1^UAS.cYa/Scer\GAL4^hs.PB

(Yao et al., 2006)

shn⁰⁴⁷³⁸ has embryo | dorsal phenotype, suppressible by brk^XH

(Torres-Vazquez et al., 2001)

NOT suppressed by

Statement

Reference

shn⁰⁴⁷³⁸ has filzkorper phenotype, non-suppressible by brk^XH

(Torres-Vazquez et al., 2001)

Enhancer of

Statement

Reference

shn⁰⁴⁷³⁸/shn[+] is an enhancer of wing margin phenotype of Bx¹

(Bejarano et al., 2008)

Suppressor of

Statement

Reference

shn⁰⁴⁷³⁸ is a suppressor of dorsal ectoderm phenotype of brk^XH

(Torres-Vazquez et al., 2001)

shn⁰⁴⁷³⁸ is a suppressor of abdominal 1 ventral denticle belt phenotype of brk^XH

(Torres-Vazquez et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

brk^XH ; shn⁰⁴⁷³⁸ double mutant embryos have an intermediate phenotype between the two single mutant phenotypes; the dorsal hole typical of shn mutants is rescued, but the dorsal ectoderm is significantly reduced compared to brk mutant embryos and the cuticle is relatively more ventralised. The Filzkorper are reduced, as in shn⁰⁴⁷³⁸ single mutant embryos. The first row of anterior facing denticles in segment A1 (missing in brk^XH embryos) are recovered.

(Torres-Vazquez et al., 2001)

Xenogenetic Interactions

Statement

Reference

The 'dorsal open' cuticle phenotype seen in shn⁰⁴⁷³⁸ embryos is rescued by expression of Hsap\HIVEP1^Scer\UAS.cYa under the control of Scer\GAL4^hs.PB, such that the dorsal cuticle is closed and contiguous and the morphology of the embryos is much closer to wild type.

(Yao et al., 2006)

Complementation and Rescue Data

Complements

shn¹⁶⁶

(Horn et al., 2003)

Fails to complement

shn^rP005

(BDGP Project Members, 1994-1999)

shn^k16131

(BDGP Project Members, 1994-1999)

shn^k00401

(BDGP Project Members, 1994-1999)