FlyBase Allele Report: Dmel\Nrt[M54]

General Information

Symbol

Dmel\Nrt^M54

Species

D. melanogaster

Name

FlyBase ID

FBal0044724

Feature type

allele

Associated gene

Dmel\Nrt

Associated Insertion(s)

Carried in Construct

Also Known As

dab^M54

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

X ray

(Liebl et al., 2003, Hill et al., 1995)

ethyl methanesulfonate

(Hill et al., 1995)

Progenitor genotype

Cytology

Description

11bp deletion beginning in the codon for I405. The frameshift results in the translation of 2 unique residues before a stop codon is reached.

(Liebl et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:16,775,032..16,775,041 [+]

Comment:

Approximate endpoints of 11bp deletion reported as starting in codon I405. Deletions leads to frameshift and early translation termination.

(Liebl et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Nrt^M54 is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

Other

Statement

Reference

Abl¹/Df(3L)st-j7, Nrt^M54/Nrt^M2 has abnormal neuroanatomy phenotype

(Liebl et al., 2003)

Abl⁴/Abl¹, Nrt^M54 has abnormal neuroanatomy phenotype

(Liebl et al., 2003)

Abl¹, N^55e11, Nrt^M54 has visible | dominant phenotype

(Giniger, 1998)

Abl¹, Df(1)N-8, Nrt^M54 has visible | dominant phenotype

(Giniger, 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Nrt[+]/Nrt^M54 is an enhancer of heart primordium phenotype of sli²

(MacMullin and Jacobs, 2006)

Nrt^M54 is an enhancer of photoreceptor cell & axon phenotype of Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

Suppressor of

Statement

Reference

Nrt^M54/Abl¹ is a suppressor of larval intersegmental nerve | heat sensitive phenotype of N^l1N-ts1

(Crowner et al., 2003)

Nrt[+]/Nrt^M54 is a suppressor of larval intersegmental nerve | heat sensitive phenotype of N^l1N-ts1

(Crowner et al., 2003)

Other

Statement

Reference

Abl¹/Df(3L)st-j7, Nrt^M54/Nrt^M2 has larval ventral nerve cord commissure phenotype

(Liebl et al., 2003)

Abl⁴/Abl¹, Nrt^M54 has larval ventral nerve cord commissure phenotype

(Liebl et al., 2003)

Abl¹, N^55e11, Nrt^M54 has eye phenotype

(Giniger, 1998)

Abl¹, Df(1)N-8, Nrt^M54 has eye phenotype

(Giniger, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

rhea¹/+; sli²/+ embryos show defects in heart formation.

(MacMullin and Jacobs, 2006)

31% of segments have commissure defects in the central nervous system of Abl¹ Nrt^M54/Abl⁴ embryos. 63% of segments have commissure defects in the central nervous system of Abl¹ Nrt^M54/Nrt^M2 Df(3L)st-j7 embryos.

(Liebl et al., 2003)

The defects in photoreceptor cell projection patterns seen in larvae overexpressing msn^EP549 under the control of Scer\GAL4^GMR.PF are enhanced by Nrt^M54.

(Ruan et al., 2002)

Heterozygotes of Df(1)N-8 or N^55e11 with Abl¹, Nrt^M54 or In(3L)std11 show defects in eye development leading to rough eyes with high penetrance.

(Giniger, 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Induced on: Abl¹. The Nrt^M54 mutant allele was originally thought to be a mutation in the Dab gene (see FBrf0049327, FBrf0058531 and FBrf0084025), but sequencing of the chromosome indicates that it is a lesion in the Nrt gene.

(Liebl et al., 2003)

Comments

"X ray" was stated as tentative. "ethyl methanesulfonate" was stated as tentative. Haploinsufficiency dependent upon an Abl mutant background (HDA).

(Hill et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Dab^m54

Nrt^M54

(Becker et al., 2016)

Nrt^m54

dab^M54

(Knox et al., 2011, MacMullin and Jacobs, 2006, Giniger, 2003.7.28, Liebl et al., 2003, Ruan et al., 2002, Giniger, 1998)

dab^m54

(Hill et al., 1995)

nrt^M54

(Crowner et al., 2003, Giniger, 2003.7.28, Liebl et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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