FlyBase Allele Report: Dmel\Scr[Wrv4]

General Information

Symbol

Dmel\Scr^Wrv4

Species

D. melanogaster

Name

FlyBase ID

FBal0045053

Feature type

allele

Associated gene

Dmel\Scr

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Hazelrigg and Kaufman, 1983)

Progenitor genotype

Scr^W

(Hazelrigg and Kaufman, 1983)

Caused by aberration

Df(3R)Scx4

Cytology

Description

Deficiency breakpoint affecting the upstream Scr imaginal leg enhancer. The Scr transcription unit is not removed by the deficiency.

(Southworth and Kennison, 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with Scr¹)

(Southworth and Kennison, 2002)

visible (with Scr⁴)

(Southworth and Kennison, 2002)

visible (with Scr^CP1)

(Southworth and Kennison, 2002)

visible (with Scr^LIN)

(Southworth and Kennison, 2002)

visible (with Scr^Tpl9)

(Southworth and Kennison, 2002)

visible (with Scr^WIN11)

(Southworth and Kennison, 2002)

visible | dominant

(Southworth and Kennison, 2002)

Phenotype Manifest In

mesothoracic leg | male

(Hazelrigg and Kaufman, 1983)

metathoracic leg | male

(Hazelrigg and Kaufman, 1983)

sex comb

(Southworth and Kennison, 2002)

sex comb (with Scr¹)

(Southworth and Kennison, 2002)

sex comb (with Scr⁴)

(Southworth and Kennison, 2002)

sex comb (with Scr^CP1)

(Southworth and Kennison, 2002)

sex comb (with Scr^LIN)

(Southworth and Kennison, 2002)

sex comb (with Scr^Tpl9)

(Southworth and Kennison, 2002)

sex comb (with Scr^WIN11)

(Southworth and Kennison, 2002)

sex comb | ectopic

(Hazelrigg and Kaufman, 1983)

Detailed Description

Statement

Reference

Heterozygous males have a reduced number of sex comb teeth on the first leg. Scr^Wrv4/Scr^Tpl9 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfd^rv1) show 94% viability and have an average of 2.1 sex comb teeth per first leg. Scr⁴/Scr^Wrv4 males have an average of 0.04 sex comb teeth on the first leg (compared to 10.8 per leg in wild type). Scr^Msc/Scr^Wrv4 males have no ectopic sex comb teeth on the second legs. Scr^Msc/Scr^Wrv4 males have no ectopic sex comb teeth on the third legs. Scr^WIN11/Scr^Wrv4 males have no sex comb teeth on the first leg. Scr^CP1/Scr^Wrv4 males have no sex comb teeth on the first leg. Scr^LIN/Scr^Wrv4 males have an average of 3.8 sex comb teeth on the first leg.

(Southworth and Kennison, 2002)

Revertant for the 'Scx' phenotype (extra sex combs on the meso- and metathoracic legs). Shows a Scr phenotype.

(Hazelrigg and Kaufman, 1983)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scr^Wrv4/Scr^Tpl9 has sex comb phenotype, non-enhanceable by z^11G3

(Southworth and Kennison, 2002)

Scr^Wrv4/Scr^Tpl9 has sex comb phenotype, non-enhanceable by z^a

(Southworth and Kennison, 2002)

Scr^Wrv4/Scr^Tpl9 has sex comb phenotype, non-enhanceable by z¹

(Southworth and Kennison, 2002)

NOT suppressed by

Statement

Reference

Scr^Wrv4/Scr^Tpl9 has sex comb phenotype, non-suppressible by z^11G3

(Southworth and Kennison, 2002)

Scr^Wrv4/Scr^Tpl9 has sex comb phenotype, non-suppressible by z¹

(Southworth and Kennison, 2002)

Scr^Wrv4/Scr^Tpl9 has sex comb phenotype, non-suppressible by z^a

(Southworth and Kennison, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The viability and average number of sex comb teeth per first leg in Scr^Tpl9/Scr^Wrv4 males (in which the haplolethality of the Df(3R)Tpl9 chromosome has been rescued by Dp(3;3)Dfd^rv1) is not affected if they are also carrying z¹, z^a or z^11G3.