FB2024_03 , released June 25, 2024
Allele: Dmel\Scr1
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General Information
Symbol
Dmel\Scr1
Species
D. melanogaster
Name
FlyBase ID
FBal0015277
Feature type
allele
Associated gene
Dmel\Scr
Associated Insertion(s)
Carried in Construct
Also Known As
EdD8, Scrd8
Key Links
Genomic Maps

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Sivanantharajah and Percival-Smith, 2009)

loss of function allele

(Pattatucci et al., 1991)
Mutagen
ethyl methanesulfonate
(Pattatucci et al., 1991, Lewis et al., 1980, Lewis et al., 1980)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Pattatucci et al., 1991)
Description

Amino acid replacement: E365K.

(Sivanantharajah and Percival-Smith, 2009)

Nucleotide substitution: G1093A.

(Sivanantharajah and Percival-Smith, 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,825,543..6,825,543 [-]
Nucleotide change:

G6825543A

Reported nucleotide change:

G1093A

Amino acid change:

E365K | Scr-PA; E365K | Scr-PB; E365K | Scr-PD; E365K | Scr-PE; E365K | Scr-PF

Reported amino acid change:

E365K

(Sivanantharajah and Percival-Smith, 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The larval head structures of homozygous mutants is not deformed and the T1 beard is not significantly reduced compared to wild type.

      Homozygous clones in the proboscis show a weak proboscis to maxillary palp transformation, but pseudotrachea still form.

      Heterozygous males have a reduction in the number of sex comb bristles on the prothoracic leg compared to wild-type males.

      (Sivanantharajah and Percival-Smith, 2009)

      Heterozygous males have a reduced number of sex comb teeth on the first leg (average is 6.1 per leg in these animals). Heterozygous males have no ectopic sex comb teeth on the second or third legs. Scr1/ScrAntp-A41 males have an average of 0.3 sex comb teeth on the first leg.

      (Southworth and Kennison, 2002)

      Mitotic clones in the tarsi of wild type do not exhibit transformation to aristae.

      (Percival-Smith et al., 1997)

      Heterozygous males exhibit a reduction in the number of sex comb teeth, indicating a homeotic transformation of prothoracic to mesothoracic leg identity.

      (Lewis et al., 1980)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Scr1 is an enhancer of eye phenotype of CycEJP

      (Brumby et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Scr1/Df(3R)Antp7 males have an average of 5.3 sex comb teeth on the first leg.

      (Southworth and Kennison, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Denell.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (12)